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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (11): 1006-1013.doi: 10.3736 jcim20101101

• Review • Previous Articles     Next Articles

Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines

Daniel Webera,b,c,Janelle M Wheata,d,e,Geoffrey M Curriea,d,e   

  1. a Faculty of Science, Charles Sturt University, Wagga Wagga, NSW 2678, Australia
    b Panaxea Medicine, PO BOX 269 Alexandria, Sydney, NSW 2015, Australia
    c World Federation of Chinese Medicine Societies, Beijing 100101, China
    d Centre for Research in Complex Systems, Charles Sturt University, Wagga Wagga, NSW 2678, Australia
    e Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia
  • Received:2010-07-05 Accepted:2010-08-17 Online:2010-11-20 Published:2010-11-15
  • Contact: Daniel Weber

Both historically and contemporarily, cancer is seen as an inflammatory process. Evidence has emerged in the last two decades that at the molecular level most chronic diseases, including cancer, are caused by a dysregulated inflammatory response. The identification of transcription factors such as nuclear factor-kappa B and signal transducer and activator of transcription 3 and their gene products such as tumor necrosis factor, interleukin-1, interleukin-6, chemokines, cyclooxygenase-2, and vascular endothelial growth factor, adhesion molecules and others has provided the molecular basis for the role of inflammation in cancer. Tumor initiation, its progression and metastasis and the failure of immune suppression of tumors all can be attributed in part to chronic and systemic inflammation. Chinese herbs have a long history in both treatment of cancer and suppres?sion of inflammation. This paper looks at recent research on cancer and inflammation and Chinese herbs and compounds, which can be used in the treatment of cancer.

Key words: Neoplasms, Inflammation, Chemokine, Cytokines, Drugs,Chinese herbal

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[9] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[10] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50