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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (11): 1014-1017.doi: 10.3736/jcim20101102

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A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression

Xin-jun Wang,Ling-ling Wang   

  1. Laboratory of Integrated Acupuncture and Medicine,Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
  • Received:2010-04-15 Accepted:2010-06-02 Online:2010-11-20 Published:2010-11-15
  • Contact: Ling-ling Wang

Clinical and experimental studies show that the onset of effect of acupuncture on depression is more rapid than selective serotonin reuptake inhibitors, a class of antidepressants. Acupuncture treatment is characterized by controlling anxiety and gastrointestinal discomfort. The onset time of acupuncture treatment for various pains is a week or so, which is the same as the rapid onset time of antidepressant effect of acupuncture, and the main pathway of acupuncture analgesia is through endogenous opioid system. Opioid peptides can produce pleasure, and decrease anxiety and gastrointestinal discomfort, so opioid peptides are considered to have antidepressant effect. Accordingly, the main pathway of acupuncture analgesia — the endogenous opioid system, is considered a mechanism for rapid onset of acupuncture effects on depression.

Key words: Acupuncture, Depression, Endogenous opioid peptides

[1] Li SR, Shen YD, Zhang WX, Chen CH, Huang YQ, Wang DP, Wang JR, Tu J, Ning ZX, Fu LM, Ji LP, Liu ZG, Wu HM, Luo KL, Zhai ST, Yan H, Meng GR. Epidemiological survey on mental disorders in 7 areas of China[J]. Zhonghua Shen Jing Ke Za Zhi,1998,31(2):80
doi: 10.3760/j:issn:1006-7884.1998.02.020
李淑然, 沈渔笛, 张维熙, 陈昌惠, 黄悦勤, 王德平, 王金荣, 涂健, 宁佐喜, 付力牧, 纪丽萍, 刘志广, 吴化民, 罗开林, 翟书涛, 严和, 孟国荣. 中国七个地区神经症流行病学调查[J].中华精神科杂志, 1998,31(2):80
doi: 10.3760/j:issn:1006-7884.1998.02.020
[2] Cao XM, Yang ZX, Xie HL, Zhang Y, Zhang JC, Rao XD . Randomized control study on depression induced by chronic pain treated with acupuncture[J]. World J Acu-moxi, 2007,17(3):1-8
doi: 10.1109/9.701086
[3] Wang XJ, Wang LL, Qiao HF, Li JB . Acupuncture combined with herbal medicine in treatment of 50 cases of depression[J]. Jiangsu Zhong Yi Yao, 2008,40(12):74-76
王欣君, 王玲玲, 乔慧芬, 李建兵 . 针药结合治疗抑郁症50例临床观察[J]. 江苏中医药, 2008,40(12):74-76
[4] Wang XJ, Wang LL, Qiao HF, Li JB . Observing clinical efficacy and characteristics of acupuncture and medicine in treating depression sleep disorders[J]. Zhen Jiu Lin Chuang Za Zhi, 2008,24(12):1-2
doi: 10.3969/j.issn.1005-0779.2008.12.001
王欣君, 王玲玲, 乔慧芬, 李建兵 . 针药结合治疗抑郁症睡眠障碍临床疗效观察[J]. 针灸临床杂志, 2008,24(12):1-2
doi: 10.3969/j.issn.1005-0779.2008.12.001
[5] Zhang JB, Wang LL, Lu M, Liu LY, Li D . Effects of acupuncture at different acupoints on behaviors in depression model rats[J]. Zhongguo Zhen Jiu, 2005,25(9):639-643
张建斌, 王玲玲, 吕梅, 刘兰英, 利达 . 针刺不同腧穴对抑郁症模型大鼠行为学的影响[J]. 中国针灸, 2005,25(9):639-643
[6] Liu LY, Wang LL, Lu M, Li D . Efficacy of electro-acupuncture combined with SSRI drugs on HAMD score in depression[J]. Sichuan Zhong Yi, 2005,23(7):96-98
doi: 10.3969/j.issn.1000-3649.2005.07.071
刘兰英, 王玲玲, 吕梅, 利达 . 电针结合SSRI类药物对抑郁症患者HAMD量表的影响[J]. 四川中医, 2005,23(7):96-98
doi: 10.3969/j.issn.1000-3649.2005.07.071
[7] Darko DF, Risch SC, Gillin JC, Golshan S . Association of beta-endorphin with specific clinical symptoms of depression[J]. Am J Psychiatry, 1992,149(9):1162-1167
doi: 10.1176/ajp.149.9.1162 pmid: 1503128
[8] Sheline YI . 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity[J]. Biol Psychiatry, 2000,48(8):791-800
doi: 10.1016/S0006-3223(00)00994-X
[9] Hung K, Wu H, Mizoguchi H, Leitermann R, Tseng LF . Intrathecal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine blocks the antinociception induced by endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse[J]. J Pharmacol Sci, 2003,93(3):299-306
doi: 10.1254/jphs.93.299
[10] Huang EY, Chen CM, Tao PL . Supraspinal anti-allodynic and rewarding effects of endomorphins in rats[J]. Peptides, 2004,25(4):577-583
doi: 10.1016/j.peptides.2004.02.009 pmid: 15165712
[11] Zhang H, Torregrossa MM, Jutkiewicz EM, Shi YG, Rice KC, Woods JH, Watson SJ, Holden Ko MC . Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through δ- and μ-opioid receptors independent of antidepressant-like effects[J]. Eur J Neurosci, 2006,23(4):984-994
doi: 10.1111/ejn.2006.23.issue-4
[12] Fichna J, Janecka A, Piestrzeniewicz M, Costentin J, do Rego JC .Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice[J]. Neuropsychopharmacology, 2007,32(4):813-821
doi: 10.1038/sj.npp.1301149 pmid: 16823383
[13] Cryan JF, Mombereau C, Vassout A . The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice[J]. Neurosci Biobehav Rev, 2005,29(4-5):571-625
doi: 10.1016/j.neubiorev.2005.03.009
[14] Petit-Demouliere B, Chenu F, Bourin M . Forced swimming test in mice: a review of antidepressant activity[J]. Psychopharmacology (Berl), 2005,177(3):245-255
doi: 10.1007/s00213-004-2048-7 pmid: 15609067
[15] Fichna J, do-Rego JC, Kosson P, Costentin J, Janecka A . Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position[J]. Biochem Pharmacol, 2005,69(1):179-185
doi: 10.1016/j.bcp.2004.09.011
[16] Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A , LeMeur M, Valverde O, Maldonado R, Kieffer BL.Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses[J]. Nat Genet, 2000,25(2):195-200
doi: 10.1038/76061
[17] Li ZR. Experimental acupuncture(2nd ed)[M]. Beijing: China Press of Traditional Chinese Medicine, 2007,( 2nd ed):137
李忠仁 . 实验针灸学(第2版)[M]. 北京: 中国中医药出版社, 2007,( 第2版):137
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