清肝活血方治疗酒精性肝病的临床研究

doi:10.3736/jcim20030206

Abstract

Objective

To study the effect of Qinggan Huoxue Recipe on alcoholic liver disease (ALD).

Methods

Effects were observed of Qinggan Huoxue Recipe on the symptoms, physical signs, liver function, blood lipid, markers of liver fibrosis, cytokine and ultrasonogram of ALD patients; the control groups were treated with Xiao Chaihu Decoction or general supportive treatment.

Results

The effects of Qinggan Huoxue Recipe were better than that of the other treatments on anorexia, nausea, vomiting, jaundice, ALT, AST and TG; the effects of Qinggan Huoxue Recipe on GGT and VLDL were better than that of the general supportive treatment. Qinggan Huoxue Recipe could decrease the level of cytokines and markers of liver fibrosis, its total effective rate was better than that of Xiao Chaihu Decoction and general supportive treatment.

Conclusion

Qinggan Huoxue Recipe could prevent and cure ALD markedly, its mechanism might be: resisting lipid peroxidation, stabilizing the membrane of the hepatocytes, rectifying the disturbance of liver lipid metabolism, adjusting the immune function, anti-fibrosis, and promoting the metabolism of ethanol in the liver.

Key words: alcoholic liver disease, Qinggan Huoxue Recipe, hepatic fibrosis, lipid peroxidation, cytokine

CLC Number:

R657.31

Guang Ji. Clinical study on treatment of alcoholic liver disease by Qinggan Huoxue Recipe. Journal of Chinese Integrative Medicine, 2003, 1(2): 103-107.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20030206

http://www.jcimjournal.com/EN/Y2003/V1/I2/103

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组别		例数	食欲减退	恶心	呕吐	乏力	上腹不适、疼痛	黄疸
清肝活血方组	治疗前	60	60	46	60	54	16	8
清肝活血方组	治疗后		10**^△△▲▲	0**^△△▲▲	23**	5**	0**^△△▲▲	0*^△▲
小柴胡冲剂组	治疗前	30	26	20	26	22	15	4
小柴胡冲剂组	治疗后		22	16	24	10*	6*^▲▲	2
一般治疗组	治疗前	30	30	26	28	16	11	5
一般治疗组	治疗后		28	10**	26	10	8	2

组别		例数	ALT（U/L）	AST（U/L）	GGT（U/L）
清肝活血方组	治疗前	60	112.59±46.23	156.28±54.23	189.48±47.18
清肝活血方组	治疗后	60	31.48±7.15**^△△▲▲	45.18±9.81**^△△▲▲	55.74±19.65**^▲▲
小柴胡冲剂组	治疗前	30	120.10±53.24	154.27±52.45	184.48±38.72
小柴胡冲剂组	治疗后	30	65.25±19.33**	86.47±19.05**^▲	69.71±33.11**
一般治疗组	治疗前	30	117.67±78.18	151.33±65.24	177.61±29.38
一般治疗组	治疗后	30	71.47±28.56**	72.20±25.95**	98.18±26.98**

组别		例数	TG（mmol/L）	TCH（mmol/L）	VLDL（mmol/L）
清肝活血方组	治疗前	60	2.14±0.80	4.14±0.91	0.35±0.10
清肝活血方组	治疗后		1.14±0.22**^△△▲▲	4.37±1.02**	0.28±0.04**^▲▲
小柴胡冲剂组	治疗前	30	2.41±0.63	4.16±0.99	0.31±0.10
小柴胡冲剂组	治疗后		2.01±0.39**	4.68±1.09*	0.24±0.08^▲
一般治疗组	治疗前	30	2.16±0.41	4.14±1.21	0.35±0.06
一般治疗组	治疗后		1.91±0.48*	5.11±1.25*	0.33±0.09**

组别	例数	LM（μg/L）	P-Ⅲ-P（μg/L）	HA（μg/L）	Col Ⅳ(ng/L)
清肝活血方组	60	37.27±12.48**^△△	9.29±4.33**^△△	157.23±70.1**^△△	10.13±2.67*^△
小柴胡冲剂组	30	17.28±5.14	3.22±1.01^△	87.94±78.65	6.61±3.44
一般治疗组	30	21.32±8.04	0.94±0.26	103.44±87.28	6.55±3.38

组别	例数	IL-1（ng/L）	IL-6（ng/L）	TNF-α（μg/L）	TGF-α(ng/L)
清肝活血方组	60	64.33±13.11^△△	30.03±11.61**^△△	2.39±0.31**^△△	4.89±2.51
小柴胡冲剂组	30	65.37±15.37^△△	18.84±10.11^△	1.79±0.84	4.88±2.13
一般治疗组	30	51.38±20.04	12.29±2.34	1.36±0.52	5.41±1.95

Clinical study on treatment of alcoholic liver disease by Qinggan Huoxue Recipe

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组别	例数	MDA(nmol/g)	SOD(U/g)
清肝活血方组	60	9.49±10.84	79.46±15.49**^△△
小柴胡冲剂组	30	8.51±5.94	35.47±25.24
一般治疗组	30	8.79±7.93	34.80±26.35

组别	临床治愈（n）	显效（n）	有效（n）	无效（n）	总有效率（%）
清肝活血方组	17	25	15	3	95.00
小柴胡冲剂组	5	9	12	4	86.67
一般治疗组	3	10	13	4	86.67