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Journal of Integrative Medicine ›› 2019, Vol. 17 ›› Issue (1): 46-56.doi: 10.1016/j.joim.2018.11.008

• Original Experimental Research • Previous Articles     Next Articles

Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicin-isoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress

Lucky Legbosi Nwidu a(), Yibala Ibor Oboma b   

  1. a Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Choba, PMB 5323 Port Harcourt, Rivers State, Nigeria
    b Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Amassoma, PMB 071 Yenegoa, Bayelsa State, Nigeria
  • Received:2018-06-17 Accepted:2018-07-30 Online:2019-01-15 Published:2019-05-18

Objective
Drug-induced liver injury complicates antituberculosis drug treatment and is a leading cause of death worldwide. The aim of this study is to establish the ethnomedicinal claim of hepatoprotective effects of fruit pulp extract of Telfairia occidentalis against rifampicin (RIF) and isoniazid (INH)-induced oxidative stress in rats.
Methods
T. occidentalis pulp extract (TOPE) (125–500?mg/kg) and silymarin (50?mg/kg) were evaluated in an induced hepatotoxicity model of oxidative stress in Wistar rats by intoxication with RIF and INH (100?mg/kg each) orally for 60?d. Markers indicating oxidative stress and hepatic damage such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed. Biomarkers of antioxidant status, including catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase, and marker of lipid peroxidation, malondialdehyde (MDA), were assayed using standard procedures. The hematological profile, lipid profile, serum markers for kidney function and histopathological examination were also assessed.
Results
Intoxication with RIF and INH markedly reduced the hematological indices and elevated the biochemical enzyme markers (AST, ALT and ALP, P?<?0.001) and lipid profile (P?<?0.001), while antioxidant biomarkers were significantly (P?<?0.01) depressed and MDA was elevated. However, pretreatment with TOPE significantly (P?<?0.001) alleviated this alteration and sustained the antioxidant potentials. The histopathological morphology supports the biochemical evidence of hepatoprotection.
Conclusion
Current study is indicative of potential antioxidant activity, hepatoprotective effects and plausible therapeutic alleviation of RIF-INH-induced hepatotoxicity of TOPE in laboratory animals.

Key words: Telfairia occidentalis, Pulp extract, Oxidative stress, Antioxidant, Lipid peroxidation, Hepatoprotective

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