健胃愈疡颗粒剂对胃溃疡患者胃黏膜表皮生长因子受体表达的影响

doi:10.3736/jcim20040109

Abstract

Objective: To observe the effect of Jianwei Yuyang Granules on the expression of epidermal growth factor receptor (EGFR) in the gastric mucosa of gastric ulcer patients. Methods: Sixty gastric ulcer patients (final diagnosis by gastroscope) were randomly divided into Jianwei Yuyang Granules treated group (JWYY group, n=30) and western medicine treated group (control group, n=30). Ten patients without gastric mucosa lesion were treated as normal control group. The expression of EGFR in the mucosa was tested by immunohistochemistry and RT-PCR. Results: Expression of EGFR and EGFR mRNA was not observed in patients without gastric mucosa lesion, and slight expression was observed in the edge of ulcer region of the gastric ulcer patients. The expression of EGFR and EGFR mRNA was increased in JWYY group and control group.Conclusion: Jianwei Yuyang Granules enhances the expression of EGFR in the mucosa of gastric ulcer patients to prevent peptic ulcer recurrence.

Key words: Jianwei Yuyang Granules, stomach ulcer, epidermal growth factor receptor

CLC Number:

R573.11

Wei-ning Zhang, Ye Zhang, Jia-bang Li. Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients. Journal of Chinese Integrative Medicine, 2004, 2(1): 24-26.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040109

http://www.jcimjournal.com/EN/Y2004/V2/I1/24

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Group	n	Before treatment	After treatment
Treatment group	30	3.9±2.0^△△	15.4±3.2**
Control group	24	3.6±2.1^△△	15.8±2.5**
Normal group	10	1.5±1.2	-

Group	n	Before treatment	After treatment
Treatment group	30	0.046±0.032^△△	0.201±0.038**
Control group	24	0.058±0.028^△△	0.187±0.037**
Normal group	10	0.021±0.017	-

Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients

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