Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 24-26.doi: 10.3736/jcim20040109

• Original Clinical Research • Previous Articles     Next Articles

Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients

Wei-ning Zhang1, Ye ZHANG2, Jia-bang Li3   

  1. 1. Depar tment of Internal Medicine, Futian Distr ict Hospital of Tr aditional Chinese Medicine, Shenzhen , Guangdong Province 518034 , China;
    2. Depar tment of Obstet rics Gynecology , First Affiliated Hospital , Hunan College of Tr aditional Chinese Medicine , Changsha , Hunan Province 410007 , China
    3. Institute of Integra ted T raditional Chinese and Western Medicine,Xiangya Hospital , Cent ral South Unive rsity , Changsha , Hunan Province 410008 , China
  • Online:2004-01-20 Published:2018-10-25

Objective: To observe the effect of Jianwei Yuyang Granules on the expression of epidermal growth factor receptor (EGFR) in the gastric mucosa of gastric ulcer patients. Methods: Sixty gastric ulcer patients (final diagnosis by gastroscope) were randomly divided into Jianwei Yuyang Granules treated group (JWYY group, n=30) and western medicine treated group (control group, n=30). Ten patients without gastric mucosa lesion were treated as normal control group. The expression of EGFR in the mucosa was tested by immunohistochemistry and RT-PCR. Results: Expression of EGFR and EGFR mRNA was not observed in patients without gastric mucosa lesion, and slight expression was observed in the edge of ulcer region of the gastric ulcer patients. The expression of EGFR and EGFR mRNA was increased in JWYY group and control group.Conclusion: Jianwei Yuyang Granules enhances the expression of EGFR in the mucosa of gastric ulcer patients to prevent peptic ulcer recurrence.

Key words: Jianwei Yuyang Granules, stomach ulcer, epidermal growth factor receptor

CLC Number: 

  • R573.11

Tab 1

Changes of EGFR expression in 3 groups (positiverate) by immunohistochemical method (ヌ±S)"

Group n Before treatment After treatment
Treatment group 30 3.9±2.0△△ 15.4±3.2**
Control group 24 3.6±2.1△△ 15.8±2.5**
Normal group 10 1.5±1.2 -

Tab 2

Changes of EGFR mRNA expression in 3groups(EGFR/β-actin) (ヌ±S)"

Group n Before treatment After treatment
Treatment group 30 0.046±0.032△△ 0.201±0.038**
Control group 24 0.058±0.028△△ 0.187±0.037**
Normal group 10 0.021±0.017 -
[1] 姒健敏, 王杭勇, 蔡建庭 , 等. 中国人溃疡病流行状况及其治疗依从性[J]. 中华内科杂志, 2000,39(3):153-155
doi: 10.3760/j.issn:0578-1426.2000.03.003
[2] 陈灏珠 . 内科学(第1版)[M]. 北京: 人民卫生出版社, 1998,( 第1版):349-355
[3] 中华人民共和国卫生部. 中药新药临床研究指导原则[S]. 1993. 79-83,96-99.
[4] 李家邦, 金益强, 陈国林 , 等. 健胃愈疡片治疗消化性溃疡的临床研究[J]. 中国中西医结合杂志, 1991,11(3):141-143
doi: 10.7661/CJIM.1991.3.141
[5] 陈文红, 李家邦 . 健胃愈疡颗粒剂对胃溃疡大鼠胃黏膜肿瘤坏死因子α mRNA表达的影响[J]. 中成药, 2000,22(6):433-435
doi: 10.3969/j.issn.1001-1528.2000.06.019
[6] 熊国良, 李家邦 . 健胃愈疡颗粒剂对胃溃疡大鼠胃黏膜上皮细胞原位凋亡的影响[J]. 湖南中医学院学报, 1999,19(4):23-24
doi: 10.3969/j.issn.1674-070X.1999.04.010
[7] 李家邦, 易振佳, 赵玉秋 , 等. 健胃愈疡片治疗消化性溃疡[J]. 湖南医科大学学报, 1991,16(2):149-152
[8] Tarnawski A, Stachural J, Durbin T , et al. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats[J]. Gastroenterology, 1992,102(2):695-698
[9] Lee H, Hansson HA, Nostrom E , et al. Immunoreactivities for epidermal growth factor(EGF) and for EGF receptors in rats with gastric ulcers[J]. Cell Tissue Res, 1991,265(2):211-218
[10] Boonstra J, Rijken P, Humbel B , et al. The epidermal growth factor[J]. Cell Biol Int, 1995,19(5):413-430
[11] Hui WM, Chen BW, Annie W , et al. Effect of epidermal growth factor on gastric blood flow in rats: possible role in mucosal protection[J]. Gastroenterology, 1993,104(6):1605-1610
[12] Tarnawski AS, Tomikawa M, Ohta M , et al. Antacid talcid activates in gastric mucosa genes encoding for EGF and its receptor. The molecular basis for its ulcer healing action[J]. J Physiol Paris, 2000,94(2):93-98
[13] Tarnawski A, Arakawa T, Kobayashi K . Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: one mechanism for its ulcer healing action[J]. Dig Dis Sci, 1998,43(9 Suppl):90S-98S
[14] Tarnawski A, Tanoue K, Santos AM , et al.Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment[J]. Scand J Gastroenterol Suppl, 1995, 210: 9-14
[1] Hao Gou, Ruo-chen Huang, Yong-hua Su, Wei Li. Design of dual targeting immunomicelles loaded with bufalin and study of their anti-tumor effect on liver cancer. Journal of Integrative Medicine, 2021, 19(5): 408-417.
[2] Bérénice Colleville, Nicolas Perzo, Guillaume Avinée, Anaïs Dumesnil, Frederic Ziegler, Paul Billoir, Hélène Eltchaninoff, Vincent Richard, Eric Durand. Impact of high-fat diet and vitamin D3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice. Journal of Integrative Medicine, 2019, 17(2): 107-114.
[3] Samrat Ghosh, Kausik Bishayee, Anisur Rahman Khuda-Bukhsh​. Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: Drug-DNA interaction and signaling cascade. Journal of Integrative Medicine, 2014, 12(2): 102-114.
[4] Venkatapura C. Devaraj, Burdipad G. Krishna. Gastric antisecretory and cytoprotective effects of leaf extracts of Amaranthus tricolor Linn. in rats. Journal of Chinese Integrative Medicine, 2011, 9(9): 1031-1038.
[5] Xiao-dong Guo, Pin-kang Wei. Effect of Xiaotan Sanjie Recipe on growth of transplanted tumor and expressions of proliferating cell nuclear antigen and epidermal growth factor receptor in tissue of gastric carcinoma of nude mice. Journal of Chinese Integrative Medicine, 2007, 5(4): 432-436.
[6] Li Liu, Hong-quan Zhang​. Effects of Danshen Decoction on experimental gastric ulcer in rats and mice. Journal of Chinese Integrative Medicine, 2005, 3(1): 35-38.
Full text



[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228