Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 24-26.doi: 10.3736/jcim20040109

• Original Clinical Research • Previous Articles     Next Articles

Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients

Wei-ning Zhang1, Ye ZHANG2, Jia-bang Li3   

  1. 1. Depar tment of Internal Medicine, Futian Distr ict Hospital of Tr aditional Chinese Medicine, Shenzhen , Guangdong Province 518034 , China;
    2. Depar tment of Obstet rics Gynecology , First Affiliated Hospital , Hunan College of Tr aditional Chinese Medicine , Changsha , Hunan Province 410007 , China
    3. Institute of Integra ted T raditional Chinese and Western Medicine,Xiangya Hospital , Cent ral South Unive rsity , Changsha , Hunan Province 410008 , China
  • Online:2004-01-20 Published:2018-10-25

Objective: To observe the effect of Jianwei Yuyang Granules on the expression of epidermal growth factor receptor (EGFR) in the gastric mucosa of gastric ulcer patients. Methods: Sixty gastric ulcer patients (final diagnosis by gastroscope) were randomly divided into Jianwei Yuyang Granules treated group (JWYY group, n=30) and western medicine treated group (control group, n=30). Ten patients without gastric mucosa lesion were treated as normal control group. The expression of EGFR in the mucosa was tested by immunohistochemistry and RT-PCR. Results: Expression of EGFR and EGFR mRNA was not observed in patients without gastric mucosa lesion, and slight expression was observed in the edge of ulcer region of the gastric ulcer patients. The expression of EGFR and EGFR mRNA was increased in JWYY group and control group.Conclusion: Jianwei Yuyang Granules enhances the expression of EGFR in the mucosa of gastric ulcer patients to prevent peptic ulcer recurrence.

Key words: Jianwei Yuyang Granules, stomach ulcer, epidermal growth factor receptor

CLC Number: 

  • R573.11

Tab 1

Changes of EGFR expression in 3 groups (positiverate) by immunohistochemical method (ヌ±S)"

Group n Before treatment After treatment
Treatment group 30 3.9±2.0△△ 15.4±3.2**
Control group 24 3.6±2.1△△ 15.8±2.5**
Normal group 10 1.5±1.2 -

Tab 2

Changes of EGFR mRNA expression in 3groups(EGFR/β-actin) (ヌ±S)"

Group n Before treatment After treatment
Treatment group 30 0.046±0.032△△ 0.201±0.038**
Control group 24 0.058±0.028△△ 0.187±0.037**
Normal group 10 0.021±0.017 -
[1] 姒健敏, 王杭勇, 蔡建庭 , 等. 中国人溃疡病流行状况及其治疗依从性[J]. 中华内科杂志, 2000,39(3):153-155
doi: 10.3760/j.issn:0578-1426.2000.03.003
[2] 陈灏珠 . 内科学(第1版)[M]. 北京: 人民卫生出版社, 1998,( 第1版):349-355
[3] 中华人民共和国卫生部. 中药新药临床研究指导原则[S]. 1993. 79-83,96-99.
[4] 李家邦, 金益强, 陈国林 , 等. 健胃愈疡片治疗消化性溃疡的临床研究[J]. 中国中西医结合杂志, 1991,11(3):141-143
doi: 10.7661/CJIM.1991.3.141
[5] 陈文红, 李家邦 . 健胃愈疡颗粒剂对胃溃疡大鼠胃黏膜肿瘤坏死因子α mRNA表达的影响[J]. 中成药, 2000,22(6):433-435
doi: 10.3969/j.issn.1001-1528.2000.06.019
[6] 熊国良, 李家邦 . 健胃愈疡颗粒剂对胃溃疡大鼠胃黏膜上皮细胞原位凋亡的影响[J]. 湖南中医学院学报, 1999,19(4):23-24
doi: 10.3969/j.issn.1674-070X.1999.04.010
[7] 李家邦, 易振佳, 赵玉秋 , 等. 健胃愈疡片治疗消化性溃疡[J]. 湖南医科大学学报, 1991,16(2):149-152
[8] Tarnawski A, Stachural J, Durbin T , et al. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats[J]. Gastroenterology, 1992,102(2):695-698
[9] Lee H, Hansson HA, Nostrom E , et al. Immunoreactivities for epidermal growth factor(EGF) and for EGF receptors in rats with gastric ulcers[J]. Cell Tissue Res, 1991,265(2):211-218
[10] Boonstra J, Rijken P, Humbel B , et al. The epidermal growth factor[J]. Cell Biol Int, 1995,19(5):413-430
[11] Hui WM, Chen BW, Annie W , et al. Effect of epidermal growth factor on gastric blood flow in rats: possible role in mucosal protection[J]. Gastroenterology, 1993,104(6):1605-1610
[12] Tarnawski AS, Tomikawa M, Ohta M , et al. Antacid talcid activates in gastric mucosa genes encoding for EGF and its receptor. The molecular basis for its ulcer healing action[J]. J Physiol Paris, 2000,94(2):93-98
[13] Tarnawski A, Arakawa T, Kobayashi K . Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: one mechanism for its ulcer healing action[J]. Dig Dis Sci, 1998,43(9 Suppl):90S-98S
[14] Tarnawski A, Tanoue K, Santos AM , et al.Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment[J]. Scand J Gastroenterol Suppl, 1995, 210: 9-14
[1] Bérénice Colleville, Nicolas Perzo, Guillaume Avinée, Anaïs Dumesnil, Frederic Ziegler, Paul Billoir, Hélène Eltchaninoff, Vincent Richard, Eric Durand. Impact of high-fat diet and vitamin D3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice. Journal of Integrative Medicine, 2019, 17(2): 107-114.
[2] Samrat Ghosh, Kausik Bishayee, Anisur Rahman Khuda-Bukhsh​. Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: Drug-DNA interaction and signaling cascade. Journal of Integrative Medicine, 2014, 12(2): 102-114.
[3] Venkatapura C. Devaraj, Burdipad G. Krishna. Gastric antisecretory and cytoprotective effects of leaf extracts of Amaranthus tricolor Linn. in rats. Journal of Chinese Integrative Medicine, 2011, 9(9): 1031-1038.
[4] Xiao-dong Guo, Pin-kang Wei. Effect of Xiaotan Sanjie Recipe on growth of transplanted tumor and expressions of proliferating cell nuclear antigen and epidermal growth factor receptor in tissue of gastric carcinoma of nude mice. Journal of Chinese Integrative Medicine, 2007, 5(4): 432-436.
[5] Li Liu, Hong-quan Zhang​. Effects of Danshen Decoction on experimental gastric ulcer in rats and mice. Journal of Chinese Integrative Medicine, 2005, 3(1): 35-38.
Full text



[1] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[2] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[3] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[6] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[7] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[8] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[9] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[10] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035