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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (1): 20-22.doi: 10.3736/jcim20060106

• Original Clinical Research • Previous Articles     Next Articles

Evaluation on methodological problems in reports concerning quantitative analysis of syndrome differentiation of diabetes mellitus

Bi-cang Chen1, Qiu-ying Wu2, Cheng-bin Xiang2, Yi Zhou3, Ling-xiang Guo3, Neng-jiang Zhao3, Shu-yu Yang   

  1. 1. Second Department of Internal Medicine, Quanzhou Hospital of Traditional Chinese Medicine, Fujian College of Traditional Chinese Medicine, Quanzhou, Fujian Province 362000, China
    2. First Department of Internal Medicine, Quanzhou Hospital of Traditional Chinese Medicine, Fujian College of Traditional Chinese Medicine, Quanzhou, Fujian Province 362000, China
    3. Department of Endocrinology, Xiamen First Hospital, Fujian Medical University, Xiamen, Fujian Province 361001, China
  • Online:2006-01-20 Published:2006-01-15


To evaluate the quality of reports published in recent 10 years in China about quantitative analysis of syndrome differentiation for diabetes mellitus (DM) in order to explore the methodological problems in these reports and find possible solutions.


The main medical literature databases in China were searched. Thirty-one articles were included and evaluated by the principles of clinical epidemiology.


There were many mistakes and deficiencies in these articles, such as clinical trial designs, diagnosis criteria for DM, standards of syndrome differentiation of DM, case inclusive and exclusive criteria, sample size and estimation, data comparability and statistical methods.


It is necessary and important to improve the quality of reports concerning quantitative analysis of syndrome differentiation of DM in light of the principles of clinical epidemiology.

Key words: Diabetes mellitus, Syndrome differentiation, Quantitative, Evaluation studies

CLC Number: 

  • R-03
[1] 中国中医药学会内科学会消渴病专业委员会. 消渴病(糖尿病)中医分期辨证与疗效评定标准[J]. 中国医药学报, 1993,8(3):54-56
[2] 凌昌全 . 关于中医证候研究的几点看法[J]. 中西医结合学报, 2004,2(2):86-89
Ling CQ . Pondering the research on syndrome of traditonal Chinese medicine[J]. Zhong Xi Yi Jie He Xue Bao, 2004,2(2):86-89
[3] 李植延, 张荔群 . 2型糖尿病中医辨证分型与血浆内皮素及降钙素基因相关肽研究[J]. 福建中医学院学报, 2001,11(3):1-4
doi: 10.3969/j.issn.1004-5627.2001.03.001
[4] 朱章志, 熊曼琪 . Ⅱ型糖尿病患者不同证型红细胞胰岛素受体缺陷的观察[J]. 中国中西医结合杂志, 1995,15(5):226-228
doi: 10.7661/CJIM.1995.5.266
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