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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 579-584.doi: 10.3736/jcim20060607

• Original Clinical Research • Previous Articles     Next Articles

Therapeutic effects of Jinqi Jiangtang Tablet on women with polycystic ovary syndrome

Li-hui Hou1,Xin-ming Yang1,Risto Erkkola2,Xiao-ke Wu1   

  1. 1. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province 150040, China
    2. Department of Obstetrics and Gynecology, Turku University Central Hospital, Turku, Finland 20540
  • Online:2006-11-30 Published:2006-11-15

Objective

To observe the therapeutic effects of Jinqi Jiangtang Tablet (JQJTT), a commonly prescribed recipe for type 2 diabetes in traditional Chinese medicine, on obese women with polycystic ovary syndrome (PCOS).

Methods

Twenty-four obese women with PCOS were prescribed JQJTT for 3 months and the changes of carbohydrate metabolism and biochemical indicators, including menstrual cycle, body mass index (BMI), the level of blood sex hormone, area under curve (AUC) of glucose and insulin during oral glucose tolerance test (OGTT), and testosterone responses during human chorionic gonadotrophin stimulation ovary test were observed.

Results

After treatment, there were significantly reductions in BMI (P<0.05), serum glucose level at 30 min during OGTT (P<0.05) and testosterone levels at eighteen hours during human chorionic gonadotrophin stimulation ovary test (P<0.05). In addition, nine patients had improved cycles among sixteen completed patients, and one patient with clomifene resistance got pregnant with response to clomifene treatment.

Conclusion

The beneficial effects of JQJTT may result from improvement of carbohydrate metabolism and reduction in androgen biosynthesis in women with PCOS.

Key words: Polycystic ovary syndrome, Insulin, Blood glucose, Androgen

CLC Number: 

  • R711.75

Table 1

General status before and after treatment (ヌ±S )"

Time;n;BMI (kg/m;2;)WHRLeft ovary volume (ml)Right ovary volume (ml)
Before treatment1628.3±4.320.9±0.217.4±6.515.3±1.2
After treatment1624.6±3.87*0.9±0.115.1±2.714.1±3.8

Table 2

Changes of blood glucose in glycometabolism (ヌ±S , mmol/L)"

Time;n;Blood glucose in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment162.32±1.115.44±4.104.23±1.913.80±2.482.92±2.51
After treatment162.52±1.014.05±1.443.84±2.263.05±1.182.07±1.19
;P;0.756 70.040 00.551 60.262 00.204 9

Table 3

Changes of C-peptide in glycometabolism (nmol/L)"

Time;n;Median of C-peptide in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment161.494.004.004.004.00
After treatment161.864.004.004.001.80
M–100.5–1.52
;P;0.803 6110.45310.3877

Table 4

Changes of insulin in glycometabolism (mU/L)"

Time;n;Median of insulin in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment1615.4259.9258.8338.6929.12
After treatment1612.94110.2293.1869.3422.45
M0.5–2–3–0.5–1
;P;10.45450.210110.8036

Table 5

Changes of glucagon in glycometabolism (ng/L)"

Time;n;Median of glucagon in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment1650.0050.0050.0066.2450.93
After treatment1650.0052.8050.0051.0750.00
M012.51.51.5
;P;10.75390.17970.54880.5488

Table 6

Comparisons of AUC Insulin, AUC Glucose and insulin sensitivity before and after treatment (ヌ±S )"

Time;n;AUC Insulin (U·L;-1;·min;-1;)AUC Glucose (mg·L;-1;·min;-1;)HOMA-IR
Before treatment16180.80±99.45116.6±46.13.15±3.73
After treatment16227.43±111.2596.2±30.22.37±2.90
;P;0.2190.0730.508

Table 7

Comparisons of reproductive hormones before and after treatment (ヌ±S )"

Time; n;Median
FSH (U/L)LH (U/L)LH/FSHE2 (pmol/L)T (nmol/L)P (nmol/L)PRL (mU/L)
Before treatment146.49.31.51011.41.8331
After treatment1471021361.61.7418
M2.5-3-2-3-1-1-19
;P;0.90.20.10.210.80.3

Table 8

Changes of P in HSOT (ヌ±S , nmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.71±0.561.67±0.581.79±0.701.79±0.792.16±1.122.16±0.98
After treatment142.66±2.831.44±0.441.54±0.631.71±1.512.18±1.352.07±0.90
;P;0.01660.56100.52680.84460.96320.7953

Table 9

Changes of T in HSOT (ヌ±S , nmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.79±0.941.32±0.841.32±0.701.28±0.931.86±0.951.74±0.91
After treatment141.79±1.201.28±0.641.26±0.721.28±0.691.58±1.08*1.49±0.75
;P;0.86950.80130.69800.99010.04930.0960

Table 10

Changes of E2 in HSOT (ヌ±S , pmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment14106.82±41.85112.50±63.85383.33±139.10588.90±271.90552.1±255.32331.35±196.70
After treatment14154.85±87.20121.54±45.90424.76±161.50631.19±211.60574.4±267.20337.90±170.20
;P;0.40.90.50.50.70.9

Table 11

Changes of 17OHP in HSOT ($\bar{x}±S$, μg/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.45±0.461.92±0.782.11±0.932.96±1.673.95±1.763.21±1.54
After treatment141.62±1.221.60±0.761.91±0.762.85±1.384.03±1.803.18±1.71
;P;00.60.50.810.8

Table 12

Changes of A2 in HSOT ($\bar{x}±S$, nmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.34±0.571.59±0.751.68±0.621.14±0.691.02±0.541.03±0.51
After treatment141.21±0.551.55±0.571.91±1.361.07±0.471.05±0.541.07±0.49
;P;0.595 20.880 80.325 90.793 40.892 50.878 2
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