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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 644-648.doi: 10.3736/jcim20060621

• Original Experimental Research • Previous Articles     Next Articles

Effect of infrared laser on pituitrin-induced bradycardia in rabbits

Xue-yong Shen1, 4,Guang-hong Ding2, 4,Jian-ping Gap3,Ling Zhao1,Jian-zi Wei1,Hai-ping Deng1,Li-zhen Wang1   

  1. 1. College of Acupuncture and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Department of Mechanics and Applied Engineering, Fudan University, Shanghai 200433, China
    3. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
    4 Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203, China
  • Online:2006-11-30 Published:2006-11-15


To observe the effect of infrared laser stimulation on Neiguan (PC 6) for bradycardia of rabbits induced by injection of pituitrin.


10.6 μm CO2 infrared laser, 650 nm semiconductor red laser and the compound laser of their aggregation were sent out by a compound laser sanatory instrument to stimulate Neiguan (PC 6) respectively for the purpose of analyzing the differences of the effects exerted by infrared laser and red laser as well as the changes of the effects after their aggregation.


After 30 min and 40 min of the injection of pituitrin, the heart rate showed no significant difference between 10.6 μm CO2 infrared laser group and the normal control group (P>0.05). However, the heart rate showed significant difference between the 650 nm semiconductor red laser group and the normal control group (P<0.05). After 30 min of the injection of pituitrin, the heart rate of the compound laser group were significantly different to that of the untreated group (P<0.05), and it was not significantly different to that of the normal control group (P>0.05). However, the heart rate of non-acupoint stimulated by the compound laser group showed no significant difference to that of the untreated group (P>0.05), and it was significantly different to that of the normal control group (P<0.05).


Stimulation on Neiguan with 10.6 μm CO2 infrared laser can evidently improve the bradycardia induced by injection of pituitrin, while the 650 nm semiconductor red laser has no such function, but they have coordinating effect. The thermal effect produced by CO2 infrared laser stimulating acupoint is probably beneficial for semiconductor laser penetrating skin as well as the biochemical reactions it carries. The improvement of heart rate produced by the laser stimulation on Neiguan (PC6)has relative specificity.

Key words: Laser, Acupuncture, Acupoint, Neiguan (PC 6), Bradycardia

CLC Number: 

  • R245

Figure 1

Sketch map of compound laser apparatus"

Table 1

Changes of heart rate of rabbits (ヌ±S, heart beat/min)"

GroupnBefore pituitrin injectionAfter pituitrin injection
5 min10 min15 min20 min25 min30 min40 min
Normal control15252.40±29.06251.33±32.01243.93±35.28246.67±31.93241.33±34.81241.93±34.17239.13±33.57244.33±32.79
10.6 μm laser Neiguan15278.67±34.98164.27±32.27*176.07±23.32*185.87±24.30*195.13±21.82*203.60±22.86*215.93±20.54226.60±21.88
650 nm laser Neiguan15269.40±47.50150.07±30.70*170.53±21.88*182.27±22.63*191.73±20.97*198.00±26.44*205.13±30.59*216.53±29.77*
Compound laser Neiguan15271.53±41.30155.20±29.19*179.73±28.76*192.20±33.48*199.07±32.95*209.47±35.56*217.67±38.16225.27±37.23
Compound laser non-acupoint15268.67±43.99140.87±24.28*163.47±20.18*172.93±19.81*183.53±20.27*193.33±21.11*203.20±22.51*220.20±26.84

Figure 2

Changes of heart rate before and after bradycardia induced by pituitrin"

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