玄参和附子抗鼠心肌肥厚作用的对比实验研究

doi:10.3736/jcim20080410

Abstract

Objective: To explore the effects of Scrophulariae of cold nature and Aconite of hot nature on myocardial hypertrophy and neuroendocrine factors in rats and mice.
Methods: A mouse model of myocardial hypertrophy was established by hypodermic injection of isoproterenol. Sixty myocardial hypertrophy mice were randomly divided into five groups: normal control group, untreated group, metoprolol-treated group, Scrophulariae-treated group and Aconite-treated group. A rat model of myocardial hypertrophy was established by peritoneal injection of L-thyroxin. Fifty rats were randomly divided into five groups: normal control group, untreated group, captopril-treated group, Scrophulariae-treated group and Aconite-treated group. After 7-9 days of treatment with intragastric administration of the corresponding drugs, the effects of Scrophulariae and Aconite on left ventricular weight index (LVWI) and heart weight index (HWI) were determined. The concentrations of cyclic adenosine monophosphate (cAMP) in plasma and angiotensinⅡ (AngⅡ) in myocardium were detected through radio-immunity method. Cardiocyte cross-section area was determined by using HE staining.
Results: Scrophulariae of cold nature could significantly reduce the LVWI, HWI and cardiocyte cross-section area, and could decrease the content of cAMP and AngⅡ. However, Aconite had no such effects.
Conclusion: Scrophulariae of cold nature can inhibit myocardial hypertrophy through restraining the activity of sympathetic nervous system and decreasing the level of AngⅡ. The inhibition of Aconite of hot nature on cardiac hypertrophy is not significant.

Key words: Scrophulariae , Aconite, cardiomyopathy, hypertrophic, comparative study, rats, mice

CLC Number:

R542.2

Wei-liang Gu, Chang-xun Chen, Ying Wang. Comparative study of Scrophulariae and Aconite in inhibiting myocardial hypertrophy in rats and mice. Journal of Chinese Integrative Medicine, 2008, 6(4): 376-380.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080410

http://www.jcimjournal.com/EN/Y2008/V6/I4/376

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References 9

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Group	n	LVWI	HWI
Normal control	12	3.02±0.23**	4.02±0.32**
Untreated	12	3.43±0.19	4.54±0.28
Metoprolol-treated	12	2.95±0.19**	3.92±0.24**
Scrophulariae-treated	12	3.00±0.27**	3.99±0.35**
Aconite-treated	12	3.34±0.16^△△	4.40±0.17^△△

Group	n	cAMP (nmol/L)	AngⅡ (ng/L)
Normal control	10	7.8±0.5**	20.4±2.1**
Untreated	10	12.3±3.1	49.2±16.3
Metoprolol-treated	10	9.3±1.4*^△	37.1±3.6*^△△
Scrophulariae-treated	10	8.9±1.1*^△	30.0±9.7**^△△
Aconite-treated	10	15.7±6.0^△△	52.8±12.1^△△

Group	n	LVWI	HWI
Normal control	10	2.37±0.09**	3.12±0.11**
Untreated	10	3.17±0.17	4.19±0.24
Captopril-treated	10	2.87±0.16**	3.91±0.22**
Scrophulariae-treated	10	2.89±0.21**	3.85±0.31**
Aconite-treated	10	3.11±0.24^△△	4.09±0.31^△△

Group	n	AngⅡ
Normal control	10	35.0±10.6**
Untreated	10	66.3±2.8
Captopril-treated	10	50.6±9.8**^△△
Scrophulariae-treated	10	59.4±6.1*^△△
Aconite-treated	10	62.5±7.5^△△

Group	n	Cardiocyte cross-section area
Normal control	8	6 705±1 163**
Untreated	8	10 300±824
Captopril-treated	8	7 532±1 264**
Scrophulariae-treated	8	7 843±1 111**
Aconite-treated	8	9 679±2 029^△△

Comparative study of Scrophulariae and Aconite in inhibiting myocardial hypertrophy in rats and mice

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