Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (10): 1000-1004.doi: 10.3736/jcim20081003

• Original Clinical Research • Previous Articles     Next Articles

Effects of Ru'ai Shuhou Recipe on 5-year recurrence rate after mastectomy in breast cancer

Sheng Liu1(), Jing Zhao1, Jia Liu2, Zhen-ping Sun1, Yong-qiang Hua1, De-ming Lu1, Han-jun Tang1   

  1. 1. Department of Breast Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    2. Department of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Xi'an, Shaanxi Province 710061, China
  • Received:2008-04-22 Online:2008-10-20 Published:2008-10-15

Objective: To observe the effects of Ru'ai Shuhou Recipe (RSR), a compound traditional Chinese herbal medicine, on 5-year recurrence rate after mastectomy in breast cancer.
Methods: A total of 300 patients with breast cancer were divided into two groups: treatment group and control group. The patients in the treatment group were treated with Western medicine and RSR, and the patients in the control group were treated only with Western medicine (the same as the treatment group). In the two groups, the 5-year recurrence rates after mastectomy in breast cancer were investigated.
Results: Thirty-four breast cancer patients were lost to five-year follow-up during the course of investigation, and 266 breast cancer patients went through the evaluation. The 5-year recurrence rate after mastectomy in the treatment group was significantly lower than that in the control group (P<0.05). The recurrence rate after mastectomy was influenced by positive lymph node, primary breast tumor size, clinical stage, and patients' health status. There was significant difference in the 5-year recurrence rates between the two groups (P<0.05) under the following conditions, such as the positive lymph nodes more than four, the primary breast tumor larger than two centimeters, and in the clinical stage Ⅱ and Ⅲ, estrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative. The recurrence rate was not associated with the operation method and age distribution.
Conclusion: RSR can reduce the 5-year recurrence rate after mastectomy in breast cancer.

Key words: breast cancer, recurrence, metastasis, Ruai Shuhou Recipe, traditional Chinese medicine

CLC Number: 

  • R737.9
[1] Shen ZZ, Shao ZM. Breast oncology[M]. Shanghai: Shanghai Scientific and Technical Publishers,2005: 115-289
沈镇宙, 邵志敏 . 乳腺肿瘤学[M]. 上海: 上海科学技术出版社,2005: 115-289
[2] Li SL. Breast oncology[M]. Beijing: Scientific and Technical Documents Publishing House,2000: 391-396
李树玲 . 乳腺肿瘤学[M]. 北京: 科学技术文献出版社,2000: 391-396
[3] Lin JL, Li LQ, Sai YD , et al. Application of COX model for evaluation of the prognostic factors in patients with breast cancer[J]. Guangxi Yi Xue, 1993,15(6):495
林进令, 黎乐群, 赛义德 , 等. COX 模型在影响乳腺癌术后预后因素分析中的应用[J]. 广西医学, 1993,15(6):495
[4] Liu M, Liu XY, Xing SQ . Influencing factors for breast cancer recurrence and metastasis after mastectomy[J]. Zhonghua Zhong Liu Za Zhi, 1993,15(2):133
刘明, 刘晓颖, 邢树乔 . 影响乳腺癌术后复发及转移的因素[J]. 中华肿瘤杂志, 1993,15(2):133
[5] Lu CL . Cause of postoperative local recurrence and the treatment for breast cancer[J]. Zhong Liu Xue Za Zhi, 2005,11(5):385-387
doi: 10.3969/j.issn.1671-170X.2005.05.024
卢崇亮 . 乳腺癌术后局部复发原因及其治疗[J]. 肿瘤学杂志, 2005,11(5):385-387
doi: 10.3969/j.issn.1671-170X.2005.05.024
[6] Tang P, Jiang J, Yang XH , et al. Clinical and pathological influencing factors for breast cancer recurrence and metastasis after mastectomy[J]. Di San Jun Yi Da Xue Xue Bao, 2007,29(11):1099-1101
唐鹏, 姜军, 杨新华 , 等. 影响乳腺癌改良根治术后复发转移的临床病理因素分析[J]. 第三军医大学学报, 2007,29(11):1099-1101
[7] Li G, Ning LS . Clinical research on ER, PR status with recurrence and distant metastatic site in primary breast cancer[J]. Zhonghua Zhong Liu Fang Zhi Za Zhi, 2006,13(3):187-189
doi: 10.3969/j.issn.1673-5269.2006.03.008
李刚, 宁连胜 . 雌孕激素受体与女性原发乳腺癌术后复发转移关系的临床研究[J]. 中华肿瘤防治杂志, 2006,13(3):187-189
doi: 10.3969/j.issn.1673-5269.2006.03.008
[8] Que HF, Wu XQ, Chen QJ . Lu Deming's experience on therapy for strengthening healthy energy in preventing and treating the recurrence and metastasis of breast cancer[J]. Liaoning Zhong Yi Za Zhi, 1998,25(7):297-298
阙华发, 吴雪卿, 陈前军 . 陆德铭扶正法为主防治乳腺癌复发转移的经验[J]. 辽宁中医杂志, 1998,25(7):297-298
[9] Wan H, Wu XQ, Lu DM . Application of method to support anti-pathogenic ability and expel pathogens in the treatment of mammary cancer[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2002,16(1):30-31
doi: 10.3969/j.issn.1008-861X.2002.01.010
万华, 吴雪卿, 陆德铭 . 扶正祛邪在治疗乳腺癌中的运用[J]. 上海中医药大学学报, 2002,16(1):30-31
doi: 10.3969/j.issn.1008-861X.2002.01.010
[10] Tang HJ . Brief on clinical and experimental study of mammary cancer[J]. Zhong Yi Yao Xue Kan, 2003,21(2):168-172
doi: 10.3969/j.issn.1673-7717.2003.02.002
唐汉钧 . 乳腺癌的中医临床与实验研究[J]. 中医药学刊, 2003,21(2):168-172
doi: 10.3969/j.issn.1673-7717.2003.02.002
[11] Lin Y, Tang HJ. Contemporary Chinese medicine in breast disease[M]. Beingjing: People's Medical Publishing House,2003: 185-189
林毅, 唐汉钧 . 现代中医乳房病学[M]. 北京: 人民卫生出版社,2003: 185-189
[12] Lu DM . Qi-enriching and yin-nourishing as major therapy in treatment of breast carcinoma after operation[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2008,22(1):1-3
doi: 10.3969/j.issn.1008-861X.2008.01.001
陆德铭 . 益气养阴法为主调治乳腺癌术后患者[J]. 上海中医药大学学报, 2008,22(1):1-3
doi: 10.3969/j.issn.1008-861X.2008.01.001
[13] Wan H, Wu XQ, Liu S . Clinical study on the impact of "Ru'ai shu hou herbs" on life quality in breast cancer patients[J]. Shanghai Zhong Yi Yao Za Zhi, 2004,38(9):28-31
万华, 吴雪卿, 刘胜 . “乳癌术后方”对乳腺癌患者生活质量影响的临床研究[J]. 上海中医药杂志, 2004,38(9):28-31
[14] Chen QJ, Situ HL, Lu DM , et al. Clinical observation of RuningⅡin inhibiting recurrence and metastasis of breast cancer[J]. Xian Dai Zhong Xi Yi Jie He Za Zhi, 2002,11(16):1546-1548
陈前军, 司徒红林, 陆德铭 , 等. 乳宁Ⅱ号抗乳腺癌短期复发转移的临床研究[J]. 现代中西医结合杂志, 2002,11(16):1546-1548
[15] Weng ZY, Quan ZW, Wu KJ . Progress of surgical treatment for breast cancer[J]. Shanghai Di Er Yi Ke Da Xue Xue Bao, 2001,21(1):93-96
翁子毅, 全志伟, 吴克瑾 . 乳腺癌外科治疗进展[J]. 上海第二医科大学学报, 2001,21(1):93-96
[1] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[2] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[3] Chang-quan Ling. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). Journal of Integrative Medicine, 2020, 18(2): 87-88.
[4] Wen Qiang Lee, Jeremy Teoh, Pei Zheng Kenneth Lee, Zhi Xiong Gerard Low, Xueling Sim, Foong Fong Mary Chong, Norbert Ludwig Wagner. Factors influencing communication of traditional Chinese medicine use between patients and doctors: a multisite cross-sectional study. Journal of Integrative Medicine, 2019, 17(6): 396-403.
[5] Mikhail Teppone. Medicine has always been “Modern” and “Scientific” from ancient times to the present day. Journal of Integrative Medicine, 2019, 17(4): 229-237.
[6] Charles Dalcanale Tesser, Ari Ojeda Ocampo Moré, Melissa Costa Santos, Emiliana Domingues Cunha da Silva, Fátima Terezinha Pelachini Farias, Lúcio José Botelho. Auriculotherapy in primary health care: A large-scale educational experience in Brazil. Journal of Integrative Medicine, 2019, 17(4): 302-309.
[7] Rachael Farrington, Ian F.Musgrave, Roger W.Byard. Evidence for the efficacy and safety of herbal weight loss preparations. Journal of Integrative Medicine, 2019, 17(2): 87-92.
[8] Carlos R. Oliveira, Daniel G. Spindola, Daniel M. Garcia, Adolfo Erustes, Alexandre Bechara, Caroline Palmeira-dos-Santos, Soraya S. Smaili, Gustavo J.S. Pereira, André Hinsberger, Ezequiel P. Viriato, Maria Cristina Marcucci, Alexandra C.H.F. Sawaya, Samantha L. Tomaz, Elaine G. Rodrigues, Claudia Bincoletto. Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development. Journal of Integrative Medicine, 2019, 17(2): 132-140.
[9] Fung-Kei Cheng. An overview of the contribution of acupuncture to thyroid disorders. Journal of Integrative Medicine, 2018, 16(6): 375-383.
[10] Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working Group. Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine. Journal of Integrative Medicine, 2018, 16(4): 236-248.
[11] Lizhou Liu, Simone Petrich, Blair McLaren, Lyndell Kelly, G. David Baxter. An integrative Tai Chi program for patients with breast cancer undergoing cancer therapy: Study protocol for a randomized controlled feasibility study. Journal of Integrative Medicine, 2018, 16(2): 99-105.
[12] Gloria Gronowicz, Eric R. Secor Jr., John R. Flynn, Liisa T. Kuhn. Human biofield therapy does not affect tumor size but modulates immune responses in a mouse model for breast cancer. Journal of Integrative Medicine, 2016, 14(5): 389-399.
[13] Qing Ji, Yun-quan Luo, Wen-hai Wang, Xuan Liu, Qi Li, Shi-bing Su. Research advances in traditional Chinese medicine syndromes in cancer patients. Journal of Integrative Medicine, 2016, 14(1): 12-21.
[14] Bing He, Ge Zhang, Ai-ping Lu. Integrative network analysis: Bridging the gap between Western medicine and traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(3): 133-135.
[15] Xuanbin Wang, Ning Wang, Fan Cheung, Lixing Lao, Charlie Li, Yibin Feng. Chinese medicines for prevention and treatment of human hepatocellular carcinoma: Current progress on pharmacological actions and mechanisms. Journal of Integrative Medicine, 2015, 13(3): 142-164.
Full text



[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[3] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[4] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[5] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[8] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[9] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[10] Ya-bing Zhou, Jian-er Yu, Jie Wu, Li Bai, Li-li Huo, Xin-guang Zhang, Li-qing Li . Effects of Chinese herbal medicine Bushen Gubiao Recipe on toll-like receptor 4 and CD4 +CD25 +foxp3 +regulatory T cells in mice with recurrent respiratory tract infections. Journal of Chinese Integrative Medicine, 2010, 8(11): 1053-1059