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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (2): 175-178.doi: 10.3736/jcim20090216

• Literature Review • Previous Articles     Next Articles

A review of studies on active agents and pharmacology of Thyme

 Zhen-xiao Suna, Qing-wen Mab   

  1. a Department of Pharmaceutics, College of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
    b Laboratory of Botany, Beijing Museum of Natural History, Beijing 100050, China
  • Received:2008-07-14 Accepted:2008-08-26 Online:2009-02-20 Published:2009-02-15

Key words: Thyme, Active agents, Pharmacology, Review

[1] Xiao PG, Lian WY. Primary color illustrated handbook of Chinese medicinal plants[M]. Beijing: Chinese Agriculture Press,1999: 418
肖培根, 连文琰 . 中药植物原色图鉴[M]. 北京: 中国农业出版社,1999: 418
[2] Ma QW, Wan P, Sun ZX, Ding ZC. Medicinal plants of Shandong Province[M]. Jinan: Shandong Science and Technology Press,1998: 181
马清温, 万鹏, 孙震晓, 丁作超 . 山东药用植物[M]. 济南: 山东科学技术出版社,1998: 181
[3] Chinese Academy of Science Flora of China Editing Committee. Flora of China(Vol 66)[M]. Beijing: Science Press, 1977,( Vol 66):250-259
中国科学院中国植物志编辑委员会. 中国植物志(第六十六卷)[M]. 北京: 科学出版社, 1977,( 第六十六卷):250-259
[4] Stahl-Biskup E, Saez F. Thyme: the genus Thymus[M]. London: CRC Press,2002: 293-316
[5] Yang ML, Hao FX, Han J . A study on the chemical components of essential oil of Thymus quinquecostatus in Ningxia Guyuan by GC-MS[J]. Ningxia Da Xue Xue Bao Zi Ran Ke Xue Ban, 2004,25(4):353-355
杨敏丽, 郝凤霞, 韩军 . 宁夏固原百里香挥发油化学成分的GC-MS研究[J]. 宁夏大学学报(自然科学版)., 2004,25(4):353-355
[6] Cheng S, Ma QW, Sun ZX . A study on the chemical components of essential oil of Thymus by GC/MS[J]. Xiang Liao Xiang Jing Hua Zhuang Pin, 2002,( 5):1-3
程霜, 马清温, 孙震晓 . 百里香挥发油化学成分的GC/MS分析[J]. 香料香精化妆品, 2002,( 5):1-3
[7] Bai Y, Liu M, Wei CY, Niu Y . Research advances in chemical composition of Thymus[J]. Nong Ye Yu Ji Shu, 1999,19(5):52-53
白岩, 刘明, 魏春雁, 牛燕 . 百里香属植物化学成分研究进展[J]. 农业与技术, 1999,19(5):52-53
[8] Ismaili H, Tortora S, Sosa S, Fkih-Tetouani S, Ilidrissi A, Della Loggia R, Tubaro A, Aquino R . Topical anti-inflammatory activity of Thymus willdenowii[J]. J Pharm Pharmacol, 2001,53(12):1645-1652
doi: 10.1211/0022357011778250
[9] Lu ZG, Takeuchi H, Liu XY . Isolation and structural analysis of monoterpene glycosides from Thyme[J]. Lin Chan Hua Xue Yu Gong Ye, 2006,26(3):23-26
陆占国, 竹内宏之, 刘向阳 . 百里香单萜糖苷的分离与构造解析[J]. 林产化学与工业, 2006,26(3):23-26
[10] Wang YP, Zhang XR, Yang QY, Wang SM . Relationships between trace elements and efficacy of Chinese medicine[J]. Shaanxi Zhong Yi, 2006,27(12):1573-1576
王懿萍, 张小荣, 杨巧艳, 王盛民 . 中药微量元素与药效的关系[J]. 陕西中医, 2006,27(12):1573-1576
[11] Wang QL, Chen QL, Fu XQ, Mu JX, Guan LX . Determination of trace elements in Thymus serpyllum L. by flame atomic absorption spectrophotometry[J]. Guyuan Shi Zhuan Xue Bao Zi Ran Ke Xue Ban, 1999,20(6):18-21
王全林, 陈全禄, 付湘清, 慕泾霞, 关凌霄 . 火焰原子吸收法测定中药百里香中的微量元素[J]. 固原师专学报(自然科学版), 1999,20(6):18-21
[12] Shi JQ, Wang QL . Determination of eight metal elements in Thymus serpyllum L. by flame atomic absorption spectrophotometry[J]. Ningxia Da Xue Xue Bao Zi Ran Ke Xue Ban, 2001,22(1):57-59
施建群, 王全林 . 百里香中8种金属元素的火焰原子吸收法测定[J]. 宁夏大学学报(自然科学版), 2001,22(1):57-59
[13] Ding JH, Li JX . Determination of trace cadmium in Chinese medicine herb Thymus serpyllum L. by graphite furnace atomic absorption spectrometry[J]. Hua Xue Yan Jiu Yu Ying Yong, 2003,15(4):575-576
丁健华, 李加新 . 石墨炉原子吸收法测定中药百里香中微量镉[J]. 化学研究与应用, 2003,15(4):575-576
[14] Shin S, Kim JH . In vitro inhibitory activities of essential oils from two Korean Thymus species against antibiotic-resistant pathogens[J]. Arch Pharm Res, 2005,28(8):897-901
doi: 10.1007/BF02973874
[15] Shin S, Kim JH . Antifungal activities of essential oils from Thymus quinquecostatus and T. magnus[J]. Planta Med, 2004,70(11):1090-1092
doi: 10.1055/s-2004-832654
[16] Segvic Klaric M, Kosalec I, Mastelic J, Pieckova E, Pepeljnak S . Antifungal activity of thyme(Thymus vulgaris L.) essential oil and thymol against moulds from damp dwellings[J]. Lett Appl Microbiol, 2007,44(1):36-42
doi: 10.1111/lam.2007.44.issue-1
[17] Hammad M, Sallal AK, Darmani H . Inhibition of Streptococcus mutans adhesion to buccal epithelial cells by an aqueous extract of Thymus vulgaris[J]. Int J Dent Hyg, 2007,5(4):232-235
doi: 10.1111/idh.2007.5.issue-4
[18] Gruenwald J, Graubaum HJ, Busch R . Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. A double-blind, randomized, placebo-controlled clinical trial[J]. Arzneimittelforschung, 2005,55(11):669-676
[19] Fan MT, Chen JP . Studies on antimicrobial activity of extracts from Thyme[J]. Wei Sheng Wu Xue Bao, 2001,41(4):499-504
樊明涛, 陈锦屏 . 百里香提取物抑菌特性的研究[J]. 微生物学报, 2001,41(4):499-504
[20] Hu Y, Du YM, Liu H . Antimicrobial activity of chitosan in combination with thymol[J]. Wuhan Da Xue Xue Bao Li Xue Ban, 2003,49(2):261-265
胡瑛, 杜予民, 刘慧 . 壳聚糖-百里香酚复合物的抑菌活性研究[J]. 武汉大学学报(理学版), 2003,49(2):261-265
[21] Nie HH, Qiu YF, Xing GQ . The anti-inflammatory activities of Thymus mongolicus Ronn.[J]. Taishan Yi Xue Yuan Xue Bao, 1993,14(4):262-265
聂恒环, 邱玉芳, 邢国庆 . 百里香挥发油的抗炎作用[J]. 泰山医学院学报, 1993,14(4):262-265
[22] Sun ZX, Sun JH, Cheng S, Ma QW, Guo SL, Zhang JB . Original studies on anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak in mice[J]. J Chin Integr Med, 2003,1(3):209-210, 238
孙震晓, 孙晋华, 程霜, 马清温, 郭善利, 张金保 . 中药地椒提取物的抗肿瘤作用及对小鼠免疫功能的影响[J]. 中西医结合学报, 2003,1(3):209-210, 238
[23] Sun ZX, Zhang YH, Cheng S, Ma QW, Guo SL, Zhang JB . Anti-tumor effect of ethanol extracts from Thymus quinquecostatus Celak on human leukemia cell line[J]. J Chin Integr Med, 2005,3(5):382-385
孙震晓, 张英慧, 程霜, 马清温, 郭善利, 张金保 . 中药地椒乙醇提取物对人白血病细胞增殖的抑制作用[J]. 中西医结合学报, 2005,3(5):382-385
[24] Cheng S, Ma QW, Sun ZX, Dai GZ . Study on antioxidant activities of subtractions from Thymus vulagaris L.[J]. Shi Pin Gong Ye Ke Ji, 2004,25(3):53-55
程霜, 马清温, 孙震晓, 戴桂芝 . 百里香萃取物的体外抗自由基活性研究[J]. 食品工业科技, 2004,25(3):53-55
[25] Wang D, Xu H . Extraction of Thymus quinpuecostatus oil by supercritical CO2 and its antioxidation effects[J]. Shi Pin Ke Xue, 2008,29(1):162-164
王娣, 许晖 . 超临界CO2萃取百里香精油及其萃取物抗氧化活性研究[J]. 食品科学, 2008,29(1):162-164
[26] Vitalini S, Grande S, Visioli F, Agradi E, Fico G, Tome F . Antioxidant activity of wild plants collected in Valsesia, an alpine region of Northern Italy[J]. Phytother Res, 2006,20(7):576-580
doi: 10.1002/(ISSN)1099-1573
[27] Zhang RY, Zhao DH, Sheng BH .Some pharmacologic effects of volatile oils of three Chinese herbs(Fructus piperis, Asarum pulchellum, Thymus serpyllum) .[J].Di Si Jun Yi Da Xue Xue Bao, 1985, 6(3):200- 204, 273-274
张荣玉, 赵德化, 盛宝恒 .山胡椒等三种中药挥发油的药理观察[J].第四军医大学学报, 1985, 6(3):200- 204, 273-274
[28] Zheng YQ, Liu PQ, Shi YJ, Nie HH . The effect of volatile oil of Thymus mongolicus Ronn. on microcirculation and its antithrombotic action in vitro[J]. Taishan Yi Xue Yuan Xue Bao, 1995,16(4):298-300
郑瑶琴, 刘培庆, 史以菊, 聂恒环 . 百里香挥发油对小鼠微循环及家兔体外血栓形成的影响[J]. 泰山医学院学报, 1995,16(4):298-300
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