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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (7): 616-621.doi: 10.3736/jcim20090704

• Original Clinical Research • Previous Articles     Next Articles

Therapy for replenishing qi, nourishing yin and promoting blood circulation in patients with acute myocardial infarction undergoing percutaneous coronary intervention: A randomized controlled trial

Sheng-lei Qiu a, Mei Jina, Jing-hong Yia, Tian-gang Zhub, Xin Quanb, Yan Lianga   

  1. a Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China
    b Department of Cardiology, Peopled Hospital, Peking University, Beijing 100044, China
  • Received:2009-02-03 Accepted:2009-04-24 Online:2009-07-20 Published:2009-07-15
  • Contact: Mei Jin E-mail:jinmei622@yahoo.com.cn

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Background

No-reflow phenomenon after reperfusion treatment of acute myocardial infarction (AMI) is becoming more recognized today. The effective treatment for no-reflow has not been reported.
Objective

To observe the effects of traditional Chinese medicine (TCM) therapy for replenishing qi, nourishing yin, and promoting blood circulation on AMI patients undergoing percutaneous coronary intervention (PCI).Design, setting, participants and interventions: This study was conducted from January 2005 to March 2006 using a double-blinded, randomized method. Thirty-five AMI patients (KillipⅠ-Ⅱ) were first diagnosed as ST segment elevation AMI and obtained primary PCI. They were recruited from People’s Hospital, Peking University. All patients’ symptoms accorded with qi-yin deficiency syndrome and blood stasis syndrome. They were randomly and double blindly divided into control group (18 cases) and treatment group (17 cases). The patients in the control group received Western medicine treatment, and the patients in the treatment group were treated with Western medicine plus American ginseng and Salviae miltiorrhizae preparations. They were all treated for 3 months.Main outcome measures: Before and after 3-month treatment, the TCM symptoms were observed and scored. At the state of baseline and dobutamine stress, left ventricular ejection fraction (LVEF), wall motion score (WMS), WMS index and normal cardiac muscle percentage (NCMP), and the myocardial contrast echocardiography index k, which reflects myocardium microcirculation perfusion, were detected.
Results

After 3-month treatment, the TCM symptoms in the treatment group were improved as compared with the control group ( χ2=4.118, P=0.042). At the state of dobutamine stress, LVEF in the treatment group after treatment was higher than those in the control group (t=2.130, P=0.041) and before treatment (t=2.345, P=0.032). Although the number of the segments with increased k value was more than that in the control group, there was no significant difference.
Conclusion

TCM therapy for replenishing qi, nourishing yin and promoting blood circulation can improve the clinical symptoms and quality of life of the AMI patients undergoing PCI, and is beneficial to myocardium microcirculation. Thus, it may be an alternative cardioprotective treatment strategy for successful myocardial microcirculation in AMI patients after reperfusion.

Key words: Myocardial infarction, Reinforcing qi, Nourishing yin, Activating blood and removing stasis, Reperfusion, Randomized controlled trial

Figure 1

Flow diagram of this randomized trial"

Table 1

Echocardiogram outcome in two groups before and after treatment （$\bar{x}$±s）"

Group n LVEF （%） WMSI NCMP （%）
Baseline Dobutamine stress Baseline Dobutamine stress Baseline Dobutamine stress
Control
Before treatment 18 53.92±7.70 60.66±12.00 1.15±0.16 1.11±0.14 85.88±15.71 90.00±14.10
Three-month treatment 18 60.00±9.33 65.15±10.53 1.15±0.22 1.14±0.17 88.94±20.16 88.94±14.49
Treatment
Before treatment 17 54.99±7.58 63.27±12.05 1.14±0.16 1.05±0.06 89.00±12.41 95.64±6.09
Three-month treatment 17 59.81±9.57 72.11±8.65*△ 1.15±0.30 1.12±0.24 90.24±13.25 92.59±16.59
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