凉血解毒活血汤预防放射性肺炎的随机对照试验

doi:10.3736/jcim20100704

Abstract

Background

Radiation pneumonitis is one of the most common complications during radiotherapy of thoracic tumors. It impacts the quality of life of the patients and has life-threatening danger. However, there is a lack of drugs for prevention and treatment of this disease.
Objective

To evaluate the efficacy of Liangxue Jiedu Huoxue Decoction, a compound traditional Chinese herbal medicine, in prevention of radiation pneumonitis.
Design, setting, participants and interventions

A prospective randomized clinical study was conducted. A total of 100 patients diagnosed with lung cancer from Department of Radiotherapy, Chinese PLA General Hospital, who were planning to receive radiotherapy, were randomly assigned into treatment group and control group, with 50 patients in each group. In the treatment group 3 cases were lost to follow-up and one case was excluded, while in the control group 6 cases were lost to follow-up and 2 cases were excluded. Patients in the treatment group were treated with Liangxue Jiedu Huoxue Decoction in addition to radiotherapy, while patients in the control group were treated with radiotherapy alone.
Main outcome measures

The incidence rates of radiation pneumonitis in the two groups were calculated. Acute radiation injury scoring criteria by Radiation Therapy Oncology Group (RTOG), clinical-radiographic-physiologic (CRP) score system, and Karnofsky Performance Status Scale (KPS) were used to evaluate the status of the patients.
Results

The incidence rate of radiation pneumonitis was lower in the treatment group than in the control group (13.04% versus 33.33%, P<0.05). According to the RTOG scale, the extent of lung injury was improved in the treatment group as compared with that in the control group (P<0.05). The CRP score in the treatment group was significantly lower than that in the control group (P<0.05). The KPS score in the treatment group was significantly higher than that in the control group (P<0.05).
Conclusion

Liangxue Jiedu Huoxue Decoction can decrease the incidence rate of radiation pneumonitis, reduce the extent of the lung injury, alleviate the symptoms of radiation pneumonitis, and improve life quality of the patients.

Key words: Radiation pneumonitis, Chinese herbal drug, Prevention, Randomized controlled trial

Chun Xiao, Hui-juan Ding, Lin-chun Feng, Bao-lin Qu, Yong-qi Dou. Efficacy of Liangxue Jiedu Huoxue Decoction in prevention of radiation pneumonitis: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2010, 8(7): 624-628.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20100704

http://www.jcimjournal.com/EN/Y2010/V8/I7/624

[1]	Dou YQ, Wei ZM, Lin MX, Hu J . Clinical observation of prophylactic effects of the method for cooling blood and activating blood on radiation pneumonitis[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 2007,13(10):64-66
	窦永起, 魏正茂, 林明雄, 呼健 . 早期应用凉血活血法预防放射性肺炎临床观察[J]. 中国实验方剂学杂志, 2007,13(10):64-66
[2]	Ministry of Health of the People’s Republic of China. Diagnostic criteria for acute radiation pneumonitis[M]. Beijing: Standards Press of China, 2002
	中华人民共和国卫生部. 急性放射性肺炎诊断标准[M]. 北京: 中国标准出版社, 2002
[3]	Ataya S, Elwing J, Biddinger P, Panos RJ . Radiation-induced lung injury[J]. Clin Pulm Med, 2006,13(4):232-242 doi: 10.1097/01.cpm.0000227598.88431.04
[4]	Cox JD, Stetz J, Pajak TF . Toxicity criteria of the Radiation Therapy Oncology Group(RTOG) and the European Organization for Research and Treatment of Cancer(EORTC)[J]. Int J Radiat Oncol Biol Phys, 1995,31(5):1341-1346 doi: 10.1016/0360-3016(95)00060-C
[5]	Watters LC, King TE, Schwarz MI, Waldron JA, Stanford RE, Cherniack RM . A clinical, radiographic and physiologic scoring system for the longitudinal assessment of patients with idiopathic pulmonary fibrosis[J]. Am Rev Respir Dis, 1986,133(1):97-103 doi: 10.1164/arrd.1986.133.1.97
[6]	Zheng XY. Guidelines for clinical research on Chinese new herbal medicines(trial implementation)[M]. Beijing: China Medical Science and Technology Press, 1993: 91-94
	郑筱萸 . 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 1993: 91-94
[7]	Han G, Zhou FX, Zhou YF . Research of radiation-induced lung injury[J]. Guo Wai Yi Xue Fang She Yi Xue He Yi Xue Feng Ce, 2005,29(6):282-286
	韩光, 周福祥, 周云峰 . 放射性肺损伤的研究[J]. 国外医学放射医学核医学分册, 2005,29(6):282-286
[8]	Graham MV, Purdy JA, Emami B, Harms W, Bosch W, Lockett MA, Perez CA . Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer(NSCLC)[J]. Int J Radiat Oncol Biol Phys, 1999,45(2):323-329
[9]	Yin Y, Yu JM, Xing LG . Dose-volume histograms for assessing radiation pneumonitis[J]. Zhonghua Zhong Liu Za Zhi, 2003,25(4):313-315
	尹勇, 于金明, 邢力刚 . 剂量体积直方图参数评估放射性肺损伤的作用[J]. 中华肿瘤杂志, 2003,25(4):313-315

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Efficacy of Liangxue Jiedu Huoxue Decoction in prevention of radiation pneumonitis: a randomized controlled trial

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