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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (8): 781-784.doi: 10.3736/jcim20100809

Special Issue: Traditional Chinese Medicine

• Original Experimental Research • Previous Articles     Next Articles

Comparative study on hypoglycemic effects of different traditional Chinese medicine treatments in rats with diabetes mellitus induced by alloxan

 JingWanga, QingWangb, Zhen-zhenWangb, ZhuoFengb, Shao-yunLiub, Qi-qiZhangb, Qi-wenCaib,Jing-juan Panb   

  1. a Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    b School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2010-05-10 Accepted:2010-06-03 Online:2010-08-20 Published:2010-08-15

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Objective

To observe hypoglycemic effects of Yunu Decoction, Zuogui Pill and Shenqi Pill, three compound traditional Chinese herbal medicines, in treatment of diabetes mellitus induced by alloxan in rats, and to compare the therapeutic effects among the three recipes for nourishing yin, clearing away heat, and nourishing yin and warming yang.
Methods

Diabetes mellitus was induced in rats with alloxan at a dose of 60 mg/kg via tail vain injection. The diabetic rats were randomly divided into four groups: alloxan model group, Yunu Decoction-treated group, Zuogui Pill-treated group and Shenqi Pill-treated group. Rats in the three recipe groups were administered intragastrically with water extraction of Yunu Decoction, Zuogui Pill, and Shenqi Pill accordingly for 10 days. Then the level of blood glucose was measured by glucose oxidase method and the glucose tolerance was determined.
Results

Compared with the normal rats, blood glucose level in the alloxan model group was obviously increased (P<0.05). Glucose levels in the three recipe groups were obviously decreased as compared with the alloxan model group (P<0.05), and glucose level in the Yunu Decoction-treated group after treatment was significant lower than before treatment (P<0.05). The glucose tolerance test indicated that rats in the alloxan model and three recipe groups revealed impaired glucose tolerance as compared with the normal rats, and there were no significant differences between the alloxan model group and the three recipe groups.
Conclusion

Yunu Decoction, Zuogui Pill and Shenqi Pill can effectively decrease the glucose level of the rats with diabetes mellitus induced by alloxan, and Yunu Decoction showed the best therapeutic effects. The glucose tolerance test shows that the three recipes cannot correct the abnormal metabolism of glucose.

Key words: Diabetes mellitus, Alloxan, Nourishing yin, Clearing away heat, Warming yang

Table 1

Effects of Yunu Decoction, Zuogui Pill, Shenqi Pill on glucose level of diabetic rats"

Figure 1

Trends of glucose levels after exogenous glucose stimulation in different groups"

[1] Ye J, Han LS, Qiu WJ, Shen YN, Gu XF . Screening of type 2 diabetes mellitus and those with high risk among children and adolescents with obesity[J]. Zhongguo Nei Fen Mi Dai Xie Za Zhi, 2004,20(2):132-135
doi: 10.3760/j.issn:1000-6699.2004.02.017
叶军, 韩连书, 邱文娟, 沈永年, 顾学范 . 儿童、青少年肥胖者2型糖尿病和高危者筛查[J]. 中国内分泌代谢杂志, 2004,20(2):132-135
doi: 10.3760/j.issn:1000-6699.2004.02.017
[2] Huang M, Wang SK, Wang XF, Dai DZ, Wang ZZ . Influences on serum insulin and glucose by different fasting time in alloxan diabetic mice[J]. Zhongguo Yao Ke Da Xue Xue Bao, 2001,32(3):217-220
doi: 10.3321/j.issn:1000-5048.2001.03.015
黄敏, 王书奎, 王小峰, 戴德哉, 王自正 . 不同禁食时间对四氧嘧啶糖尿病小鼠模型的血清胰岛素和血糖的影响[J]. 中国药科大学学报, 2001,32(3):217-220
doi: 10.3321/j.issn:1000-5048.2001.03.015
[3] Wen XH, Shen CY, Lei J, Yang ZW, Wang YP . Dynamic observation on the intraperitioneal glucose tolerance test in the non-hyperglycemic rats treated with streptozotocin[J]. Chongqing Yi Ke Da Xue Xue Bao, 2008,33(12):1467-1470
文晓红, 沈成义, 雷军, 杨正伟, 王亚平 . 链脲佐菌素未致高血糖大鼠腹腔葡萄糖耐量试验的动态观察[J]. 重庆医科大学学报, 2008,33(12):1467-1470
[4] Ma YC. Experimental traditional Chinese medicine[M]. Beijing: United Publishing House of Beijing Medical University and Chinese Union Medical University,2000:
马超英 . 实验中医学[M]. 北京: 北京医科大学中国协和医科大学联合出版社,2000:
[5] Zhu YF, Chen SR . Mechanism of pancreatic islet β cell injury in type 1 diabetes[J]. Shantou Da Xue Yi Xue Yuan Xue Bao, 2002,15(3):173-175
朱远锋, 陈慎仁 . 1型糖尿病胰岛β-细胞损伤机制[J]. 汕头大学医学院学报, 2002,15(3):173-175
[6] Ye HH, Yuan JF, Li M, Wang YJ, Dong G, Yang LP, Zhang GZ, Zhang XF, Zeng L . Different effects of alloxan on diabetic model duplication in male and female animals[J]. Zhongguo Bi Jiao Yi Xue Za Zhi, 2010,20(1):19-22
doi: 10.3969/j.issn.1671-7856.2010.01.005
叶华虎, 袁菊芳, 李敏, 王艳静, 董罡, 杨丽萍, 张广州, 张小飞, 曾林 . 四氧嘧啶诱发糖尿病模型效果的性别差异[J]. 中国比较医学杂志, 2010,20(1):19-22
doi: 10.3969/j.issn.1671-7856.2010.01.005
[7] Tong XL, Zhao LH, Chen L, Wang J . Development of study on prevention and treatment of diabetes by traditional Chinese medicine[J]. Yao Pin Ping Jia, 2009,6(12):467-470
doi: 10.3969/j.issn.1672-2809.2009.12.002
仝小林, 赵林华, 陈良, 王佳 . 糖尿病中医药防治研究进展[J]. 药品评价, 2009,6(12):467-470
doi: 10.3969/j.issn.1672-2809.2009.12.002
[8] Meng JB, Kang SQ, Kang SX, Yang Y, Zhou CG . Experimental study of diabetic models in rabbits induced by alloxan[J]. Hebei Yi Yao, 2009,31(1):19-20
doi: 10.3969/j.issn.1002-7386.2009.01.007
孟建波, 康胜群, 康素娴, 杨彦, 周晨光 . 四氧嘧啶诱导兔1型糖尿病模型的实验研究[J]. 河北医药, 2009,31(1):19-20
doi: 10.3969/j.issn.1002-7386.2009.01.007
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