Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (2): 130-133.doi: 10.3736/jcim20070205

• Original Clinical Research • Previous Articles     Next Articles

Correlation between syndromes of posthepatitic cirrhosis and biological parameters: a report of 355 cases

Qin Zhang1, Hong Qiu2, Lei Wang4, Guang-li Du3, Ping Liu4   

  1. 1. Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
    2. Teaching and Research Group of Preventive Medicine and Medical Statistics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    3. Department of Pharmacology of Traditional Chinese Medical Formulae, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    4. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Online:2007-03-31 Published:2007-03-15

Objective: To investigate the pathological factors of syndrome pathomechanism through studying the correlation between syndromes of posthepatitic cirrhosis and biological parameters. 

Methods: Clinical information of three hundred and fifty-five patients with posthepatitic cirrhosis was collected and the database was established. Parameters with statistical significance were analyzed with multi-factor regression analysis to investigate the main influencing factors of the syndromes of posthepatitic cirrhosis. 

Results: Formulae of six syndromes, including syndrome of yin deficiency of liver and kidney, syndrome of damp heat, syndrome of stagnated heat smoldering, syndrome of yang deficiency of spleen and kidney, syndrome of stagnation of liver qi and spleen deficiency and syndrome of blood stasis due to qi deficiency, were established with stepwise regression analysis. 

Conclusion: One of the pathophysiological bases of syndrome of blood stasis due to qi deficiency in cirrhosis is synthetic dysfunction of hepatocytes. The pathophysiological basis of syndrome of damp heat is inflammatory injury, which is also syndrome of stagnated heat smoldering in cirrhosis patients. The relationship between syndrome of yin deficiency of liver and kidney and stasis and damp heat may be the pathophysiological basis of the posthepatitic cirrhosis

Key words: hepatitis, liver cirrhosis, pathogenesis, TCM, regression analysis

CLC Number: 

  • R657.31
[1] 张琴, 刘平, 章浩伟 , 等. 900例肝炎后肝硬化中医证候判别模式的研究[J]. 中国中西医结合杂志, 2006,26(8):694-697
Zhang Q, Liu P, Zhang HW , et al. Study on the patterns of TCM syndrome differentiation of 900 patients with posthepatitic cirrhosis[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2006,26(8):694-697
[2] 中华医学会传染病与寄生虫病学会、肝病学分会. 病毒性肝炎防治方案[J]. 中华肝脏病杂志, 2000,8(6):324-329
Chinese Society of Infectious Diseases and Parasitology and Chinese Society of Hepatology of Chinese Medical Association. The programme of prevention and treatment for viral hepatitis[J]. Zhonghua Gan Zang Bing Za Zhi, 2000,8(6):324-329
[3] 张文彤 . SPSS 统计分析高级教程[M]. 北京: 高等教育出版社,2004. 213, 252
Zhang WT. Advanced textbook for SPSS statistical analysis[M]. Beijing: Higher Education Press,2004. 213, 252
[4] 朱虹, 肖炜明, 陆伟 , 等. 肝硬变中医辨证分型与血清载脂蛋白变化的关系[J]. 陕西中医, 2004,25(9):771-772
Zhu H, Xiao WM, Lu W , et al. Correlation between syndrome differentiation and serum apolipoprotein levels in patients with liver cirrhosis.[J]. Shannxi Zhong Yi, 2004,25(9):771-772
[5] 俞靖龙, 蔡峥, 张建荣 , 等. 肝硬化患者测定血清脂蛋白及载脂蛋白的意义[J]. 中国检验医学与临床, 2001,2(4):153-154
Yu JL, Cai Z, Zhang JR , et al. Serum lipoprotein and apolipoprotein levels in patients with liver cirrhosis[J]. Zhongguo Jian Yan Yi Xue Yu Lin Chuang, 2001,2(4):153-154
[6] 张琴, 陈慧芬, 陈良 , 等. 肝炎后肝硬化中医证候与肝功能损伤关系的探讨[J]. 上海中医药杂志, 2004,38(3):8-11
Zhang Q, Chen HF, Chen L , et al. Study on the characteristics of traditional Chinese medical syndrome of hepatocirrhosis relation with liver function disorder[J]. Shanghai Zhong Yi Yao Za Zhi, 2004,38(3):8-11
[7] 陈良, 葛培昌, 骆成榆 . 活动型肝硬化肝右叶大小与并发症的关系[J]. 上海预防医学, 1997,9(4):178-180
Chen L, Ge PC, Luo CY . Correlation between the size of right lobe of liver and complications in patients with active type liver cirrhosis[J]. Shanghai Yu Fang Yi Xue, 1997,9(4):178-180
[8] 刘树农 . 刘树农医论选[M]. 上海: 上海科学技术出版社,1987. 292
Liu SN .Selections of Liu Shunong's medical thesis[M].Shanghai: Shanghai Scientificand Technical Publishers 1987. 292
[9] 北京中医医院. 关幼波临床经验选(第2版)[M]. 北京: 人民卫生出版社, 1979,( 第2版):131-137
Beijing Hospital of Chinese Medicine. Selections of Guan Youbo's clinical experience[M]. Beijing: : People's Medical Publishing House,1979. 131-137
[10] 张琴, 刘平, 陈惠芬 , 等. 肝炎后肝硬化中医证候特点的多元分析[J]. 中西医结合肝病杂志, 2003,13(2):69-72
Zhang Q, Liu P, Chen HF , et al. Multi analysis: characteristics of traditional Chinese medical syndrome of hepatocirrhosis[J]. Zhong Xi Yi Jie He Gan Bing Za Zhi, 2003,13(2):69-72
[1] Hidetoshi Mori, Hiroshi Kuge, Shunji Sakaguchi, Tim Hideaki Tanaka, Junji Miyazaki. Determination of symptoms associated with hiesho among young females using hie rating surveys. Journal of Integrative Medicine, 2018, 16(1): 34-38.
[2] Qing Ji, Yun-quan Luo, Wen-hai Wang, Xuan Liu, Qi Li, Shi-bing Su. Research advances in traditional Chinese medicine syndromes in cancer patients. Journal of Integrative Medicine, 2016, 14(1): 12-21.
[3] Shi-li Jiang, Xu-dong Hu, Ping Liu. Immunomodulation and liver protection of Yinchenhao decoction against concanavalin A-induced chronic liver injury in mice. Journal of Integrative Medicine, 2015, 13(4): 262-268.
[4] Cláudia Maria Sousa, Luis Moreira, Daniela Coimbra, Jorge Machado, Henry J. Greten. Immediate effects of Tuina techniques on working-related musculoskeletal disorder of professional orchestra musicians. Journal of Integrative Medicine, 2015, 13(4): 257-261.
[5] Zhao-guo Li, Xi-ru Liu. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Paediatrics (Part 3). Journal of Integrative Medicine, 2015, 13(3): 201-204.
[6] Xiao Ye, Jing Wang. On English translation of infant Tuina points in traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(3): 205-207.
[7] Bing He, Ge Zhang, Ai-ping Lu. Integrative network analysis: Bridging the gap between Western medicine and traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(3): 133-135.
[8] Zhao-guo Li. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Paediatrics (Part 2). Journal of Integrative Medicine, 2015, 13(2): 129-132.
[9] Zhao-guo Li . Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Paediatrics (Part 1). Journal of Integrative Medicine, 2015, 13(1): 61-64.
[10] Arthur de Sá Ferreira, Antonio Guilherme Pacheco. SimTCM: A human patient simulator with application to diagnostic accuracy studies of Chinese medicine. Journal of Integrative Medicine, 2015, 13(1): 9-19.
[11] Chang-qing Zhao, Yang Zhou, Jian Ping, Lie-ming Xu. Traditional Chinese medicine for treatment of liver diseases: Progress, challenges and opportunities. Journal of Integrative Medicine, 2014, 12(5): 401-408.
[12] Zhao-guo Li. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Gynecology and Obstetrics (Part 3). Journal of Integrative Medicine, 2014, 12(5): 463-467.
[13] Zhao-guo Li . Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Gynecology and Obstetrics (Part 2). Journal of Integrative Medicine, 2014, 12(4): 397-400.
[14] Shu Dong, Shi-bing Su​. Advances in mesenchymal stem cells combined with traditional Chinese medicine therapy for liver fibrosis. Journal of Integrative Medicine, 2014, 12(3): 147-155.
[15] Zhao-guo Li . Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Gynecology and Obstetrics (Part 1). Journal of Integrative Medicine, 2014, 12(2): 127-130.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228