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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (12): 1246-1249.doi: 10.3736/jcim20081207

• Original Clinical Research • Previous Articles     Next Articles

Herba Saxifragae cream in treatment of chronic eczema: a randomized controlled trial

Rong Xu, Fu-lun Li, Lin-ling Zhang, Xun Song, Jing-lin Zhu, Bing Li()   

  1. Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2008-06-03 Online:2008-12-20 Published:2008-12-15

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Objective: 

To explore the clinical efficacy of Herba Saxifragae cream (HS), a compound of traditional Chinese herbal medicine, on chronic eczema.


Methods:

A total of 42 cases of chronic eczema were randomly divided into HS group (22 cases) and hydrocortisone (HC) group (20 cases). To the HS group, HS was externally applied twice a day continuously for 4 weeks. To the HC group, hydrocortisone was externally applied twice a day continuously for 4 weeks. The total score of symptom score reducing index (SSRI) was calculated before and after treatment in terms of itching degree, lesion shape and lesion area, in the evaluation of the clinical efficacy of HS on chronic eczema.


Results: 

After 2-week treatment, the total response rate of HS group was 77.3%, and the total response rate of HC group was 70.0%. After 4-week treatment, the total response rates were 86.4% and 85.0% in HS and HC groups respectively. There was no statistical difference in total scores of SSRI between the two groups (P>0.05), and neither was there the difference in the score of itching degree, lesion shape and lesion area (P>0.05).


Conclusion: 

Herba Saxifragae cream has the same effect as hydrocortisone in treating chronic eczema.

Key words: eczema, external application drugs, Herba Saxifragae cream, randomized controlled trials

CLC Number: 

  • R758.23

Table 1

Symptom score before treatment and SSRI after treatment in two groups (x±s)"

Group n Total score
before treatment		 Difference after treatment vs before treatment SSRI score after treatment
2-week 4-week 2-week 4-week
HS 22 108.91±38.23 53.73±21.97 77.18±27.52 0.53±0.19 0.75±0.20
HC 20 106.25±35.46 54.90±26.39 76.55±36.76 0.52±0.19 0.72±0.19

Table 2

Clinical efficacy in two groups"

Group n Cured
[Cases (%)]		 Obvious effect [Cases (%)] Improved
[Cases (%)]		 Failure
[Cases (%)]		 Total response
rate (%)
After 2-week treatment
HS 22 1 (4.5) 3 (13.6) 13 (59.1) 5 (22.7) 77.3
HC 20 1 (5.0) 3 (15.0) 10 (55.0) 6 (30.0) 70.0
After 4-week treatment
HS 22 4 (18.2) 11 (50.0) 4 (18.2) 3 (13.6) 86.4
HC 20 3 (15.0) 10 (50.0) 4 (20.0) 3 (15.0) 85.0
[1] Zhao B. Clinical dermatology(2nd ed)[M]. Nanjing: Phoenix Science Press, 2001,( 2nd ed):604-607
赵辨 . 临床皮肤病学(第2版)[M]. 南京: 江苏科学技术出版社, 2001,( 第2版):604-607
[2] Gu BK. Surgery of traditional Chinese medicine[M]. Shanghai: Shanghai Scientific and Technical Publishers,1986: 137-139
顾伯康 . 中医外科学[M]. 上海: 上海科学技术出版社,1986: 137-139
[3] Zhao B . Eczema area and severity index score[J]. Zhonghua Pi Fu Ke Za Zhi, 2004,37(1):3-4
doi: 10.3760/j.issn:0412-4030.2004.01.002
赵辨 . 湿疹面积及严重度指数评分法[J]. 中华皮肤科杂志, 2004,37(1):3-4
doi: 10.3760/j.issn:0412-4030.2004.01.002
[4] Zheng XY. Guiding principle of clinical research on new drugs of Chinese medicine(trial implementation)[M]. Beijing: Chinese Medical Science and Technology Press,2002: 298
郑筱萸 . 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社,2002: 298
[5] Dang NN . Study of the quality of life in different skin diseases[J]. Zhongguo Pi Fu Xing Bing Xue Za Zhi, 2004,18(4):221-222
党宁宁 . 不同皮肤病生活质量的比较研究[J]. 中国皮肤性病学杂志, 2004,18(4):221-222
[6] Wang TX, Liu GF . Analysis of the adverse effects of external corticosteroid in 160 cases[J]. Zhongguo Wu Zhen Xue Za Zhi, 2003,3(8):1178
doi: 10.3969/j.issn.1009-6647.2003.08.092
王天祥, 刘桂峰 . 外用皮质类固醇致不良反应160例分析[J]. 中国误诊学杂志, 2003,3(8):1178
doi: 10.3969/j.issn.1009-6647.2003.08.092
[7] Williams HC . Clinical practice. Atopic dermatitis[J]. N Engl J Med, 2005,352(22):2314-2324
doi: 10.1056/NEJMcp042803
[8] Li XR, Li YM . Effects of Binghuang Fule Cream in treatment of 103 patients with subacute eczema[J]. Zhongguo Zhong Xi Yi Jie He Pi Fu Xing Bing Xue Za Zhi, 2007,6(4):242-243
李晓睿, 李咏梅 . 冰黄肤乐软膏治疗亚急性湿疹103例临床疗效观察[J]. 中国中西医结合皮肤性病学杂志, 2007,6(4):242-243
[9] Feng CQ, Tian J . Application of the traditional Chinese medicine solution in external therapy of eczema[J]. Zhong Yi Wai Zhi Za Zhi, 2007,16(6):61-62
doi: 10.3969/j.issn.1006-978X.2007.06.036
冯长青, 田静 . 中药溶液在湿疹外治中的应用体会[J]. 中医外治杂志, 2007,16(6):61-62
doi: 10.3969/j.issn.1006-978X.2007.06.036
[10] Wu SX. Li Yue Pian Wen(annotation edition)[M]. Beijing: People's Medical Publishing House,1984: 4
吴尚先 . 理瀹骈文[M]. 北京: 人民卫生出版社,1984: 4
[11] Wu HJ, Lan CY, Chen Y . Study development of Sophora japonic[J]. Guangdong Wei Liang Yuan Su Ke Xue, 2006,13(6):1-6
吴红霁, 兰昌云, 陈媛 . 槐花的研究进展[J]. 广东微量元素科学, 2006,13(6):1-6
[12] Liu SW, Xu YX . Inhibition effect of ethanol extract of Saxifraga stolonifera Meerb. on microorganisms[J]. Zi Yuan Kai Fa Yu Shi Chang, 2007,23(6):481-482, 489
doi: 10.3969/j.issn.1005-8141.2007.06.001
刘世旺, 徐艳霞 . 虎耳草乙醇提取物抑菌作用的研究[J]. 资源开发与市场, 2007,23(6):481-482, 489
doi: 10.3969/j.issn.1005-8141.2007.06.001
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