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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (1): 25-34.doi: 10.3736/jcim20120105

• Systematic Review • Previous Articles     Next Articles

Systematic review and meta-analysis of randomized controlled trials comparing Chinese patent medicines Compound Danshen Dripping Pills and Di’ao Xinxuekang in treating angina pectoris

Ng Cui-shan1,2(),Wang Shan-ping1,2,Cheong Jun-long1,2,Wu Yu-dan1,2,Jia Yong-liang1,2,Leung Siu-wai1,2,3   

  1. 1. State Key Laboratory for Quality Research in Chinese Medicine, University of Macau, Macao 999078, China
    2. Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
  • Received:2011-08-17 Accepted:2011-11-07 Online:2012-01-20 Published:2018-09-21
  • Contact: Ng Cui-shan

BACKGROUND: Chinese patent medicines Compound Danshen Dripping Pills (DSP) and Di’ao Xinxuekang (DXK) capsules were both found effective in treating angina pectoris. However, there is no systematic review comparing their efficacy.OBJECTIVE: This systematic review aims to compare the efficacy of DSP and DXK in treating angina pectoris based on randomized controlled trials (RCTs) comparing their efficacy.SEARCH STRATEGY: RCT reports published between 1994 and 2011 were retrieved from databases including China Doctoral Dissertations Full-text Database, Chinese Journal Full-text Database, China Master’s Theses Full-text Database, Wanfang Data, Cochrane Library, Excerpta Medica Database, ScienceDirect, MEDLINE (EBSCOhost) and PubMed. The last retrieval was performed on April 7, 2011.INCLUSION CRITERIA: RCT reports comparing the effects of DSP and DXK were included, regardless publishing language.DATA EXTRACTION AND ANALYSIS: Included RCT reports were assessed for their study quality by using the Jadad scale and the Cochrane risk of bias tool. Data including overall effect and electrocardiography (ECG) improvements were extracted from the included RCTs for meta-analysis. The effect sizes based on overall and ECG diagnosis were measured by odds ratio (OR) and 95% confidence interval (CI). Subgroup analysis and sensitivity analysis were also performed.RESULTS: Nine RCT reports with 926 participants were included. Eight were scored 2 and the other one was scored 4 by using the Jadad scale. The OR between DSP and DXK based on overall diagnosis was 2.06 (95% CI: 1.03-4.12; Poverall=0.04). Six out of the nine included RCTs reported ECG data. The OR between DSP and DXK based on the ECG diagnosis was 1.92 (95% CI: 1.23-3.00; PECG =0.004). The OR results were stable under subgroup analysis and sensitivity analysis.CONCLUSION: DSP was consistently more effective than DXK according to meta-analysis, which was verified by subgroup analysis and sensitivity analysis. However, more RCTs of higher quality are needed for further confirmation.

Key words: compound, traditional Chinese drugs, angina pectoris, meta-analysis, randomized controlled trials

Figure 1

Flow diagram of literature search and selectionCJFD: Chinese Journal Full-text Database; CMTD: China Master’s Theses Full-text Database; CDMD: China Doctor Dissertations Full-text Database; DSP: Compound Danshen Dripping Pills; DXK: Di’ao Xinxuekang; RCT: randomized controlled trial."

Table 1

Main characteristics of included studies"

Study Year of
dosage (g)
dosage (g)
Number of
adverse events
Chen JW[17] 2005 NR Reported 124 Overall,
60 0.81 0.36 2 3
Fan YL[18] 2008 2006/1 to
Reported 234 Overall,
84 0.81 0.6 0 23
Huang ZH[19] 2009 2006 to 2008 NR 80 Overall 60 0.81 0.6 0 1
Huang YN[20] 2007 2000/1 to
Reported 80 Overall,
56 0.81 0.6 NR NR
Qin PS et al[21] 2000 1998/5 to
Reported 124 Overall,
28 0.81 0.6 NR NR
Wang D[22] 2010 NR Reported 60 Overall,
28 0.81 2.1 0 0
Yan L[23] 2007 2002/3 to
Reported 60 Overall,
56 0.81 0.6 NR NR
Yang M et al[24] 2007 NR NR 74 Overall 56 0.81 0.3 to 0.6 0 0
Zhang XC[25] 2002 2001/3 to 12 NR 90 Overall 30 0.54 0.6 NR NR

Table 2

Quality evaluation of included studies"

Study Randomization concealment Blinding Withdrawals and drop-outs Jadad score
Chen JW[17] 0 0 1 2
Fan YL[18] 2 0 1 4
Huang ZH[19] 0 0 1 2
Huang YN[20] 0 0 1 2
Qin PS et al[21] 0 0 1 2
Wang D[22] 0 0 1 2
Yan L[23] 0 0 1 2
Yang M et al[24] 0 0 1 2
Zhang XC[25] 0 0 1 2

Figure 2

A forest plot of overall outcome measures"

Figure 3

A forest plot of electrocardiography outcome measure"

Table 3

Sensitivity analysis of overall and ECG outcome measures"

Index Number of participants OR 95% CI Z value P value I2 χ2 P (heterogeneity)
Overall effect[18-21,23-25] 742 2.08 [0.88, 4.90] 1.68 0.09 69% 19.60 0.000 3
ECG[18,20,21,23] 498 2.19 [1.47, 3.24] 3.88 0.000 1 4% 3.12 0.37
Overall effect[17,18,20-25] 846 2.81 [1.64, 4.78] 3.78 0.000 2 36% 10.87 0.14

Table 4

Subgroup analysis of overall outcome measures"

Index Subgroup Number
of RCTs
Number of
OR Wilcoxon
95% CI Zvalue P value I2 χ2 P
Sample size ≤80 5 354 1.27 W=5 [0.43, 3.79] 0.43 0.66 62% 10.46 0.03
>80 5 1 006 4.11 P=0.220 7 [2.17, 7.76] 4.35 <0.0001 56% 9.02 0.06
Duration <56 d 3 274 1.49 W=6 [0.41, 5.49] 0.61 0.54 60% 4.97 0.08
≥56 d 7 1 086 2.91 P=0.438 6 [1.36, 6.22] 2.75 0.006 71% 20.88 0.002

Table 5

Subgroup analysis of ECG outcome measures"

Subgroup Number
of RCTs
Number of
OR Wilcoxon
95% CI Zvalue P value I2 χ2 P
Samplesize ≤80 3 200 1.24 W=1 [0.63, 2.41] 0.62 0.53 21% 2.53 0.28
>80 3 484 2.61 P=0.126 6 [1.76, 3.87] 4.76 <0.000 1 0 2.00 0.37
Duration <56 d 2 184 1.10 W=1 [0.44, 2.76] 0.21 0.84 49% 1.95 0.16
≥56 d 4 498 2.57 P=0.164 9 [1.75, 3.78] 4.79 <0.000 01 0% 2.54 0.47

Table 6

Statistics of adverse events"

Study Sample size Number of adverse events Incidence of adverse events
Chen JW[17] 62 62 2 3 0.032 0.048
Fan YL[18] 130 104 0 23 0 0.221
Huang ZH[19] 40 40 0 1 0 0.025
Wang D[22] 30 30 0 0 0 0
Yang M et al[24] 36 38 0 0 0 0
[1] Du HL, Liang FR . Reaction of acupuncture points in patients with coronary heart disease and its clinical practice in disease prevention[J]. Sichuan Zhong Yi,. 2010,28(11):26-27
杜怀斌, 梁繁荣 . 冠心病经络腧穴反应的研究及在“治未病”中的临床运用[J]. 四川中医,. 2010,28(11):26-27
[2] Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature[J]. Circulation, 1979,59(3):607-609
doi: 10.1161/01.CIR.59.3.607
[3] Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS, Ferguson TB Jr, Fihn SD, Fraker TD Jr, Gardin JM , O’Rourke RA, Pasternak RC, Williams SV, Gibbons RJ, Alpert JS, Antman EM, Hiratzka LF, Fuster V, Faxon DP, Gregoratos G, Jacobs AK, Smith SC Jr; American College of Cardiology; American Heart Association Task Force on Practice Guidelines.Committee on the Management of Patients With Chronic Stable Angina. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina — summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines(Committee on the Management of Patients With Chronic Stable Angina)[J]. Circulation, 2003,107(1):149-158
doi: 10.1161/01.CIR.0000047041.66447.29
[4] Chinese Pharmacopoeia Commission. Chinese pharmacopoeia 2010. Vol 1. Beijing: China Medical Science Press . 2010.
中国药典委员会. 中华人民共和国药典2010年版(一部). 北京: 中国医药科技出版社. 2010.
[5] Ran H . Pharmacological and clinical research of Compound Danshen Dripping Pills in cardiovascular diseases[J]. Jia Ting Yi Yao Yi Yao Lun Tan,. 2010,10:734-736
冉桦 . 复方丹参滴丸在心血管方面的药理与临床研究[J]. 家庭医药(医药论坛),. 2010,10:734-736
[6] Yu SY, Yu ZA. Clinical observation and experimental research of Compound Danshen Dripping Pills in treating coronary heart diseases. Proceedings of the Eighth Academic Conference of Integrated Traditional Chinese and Western Medicine on Cardiovascular Diseases. 2007: 335-339. Chinese.
于首元, 于兆安 . 复方丹参滴丸治疗冠心病心绞痛的临床疗效观察与实验研究. 第八次全国中西医结合心血管病学术会议论文集. 2007: 335-339.
[7] Zhang MZ, Wang L, Chen BJ, Nie GN . Meta-analysis of document on Compound Danshen Dropping Pills(DSP) in treatment of patients with stable angina[J]. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi,. 2004,2(6):311-314
doi: 10.3969/j.issn.1672-1349.2004.06.001
张敏州, 王磊, 陈伯钧, 聂广宁 . 复方丹参滴丸治疗稳定型心绞痛Meta分析. 中西医结合心脑血管病杂志 . 2004; 2(6):311-314.
doi: 10.3969/j.issn.1672-1349.2004.06.001
[8] Jiang SY, Tong JC, Sun RY, Xie HT . Meta-analysis of Compound Danshen Dropping Pills(DSP) in treating coronary heart disease angina[J]. Shi Yong Yao Wu Yu Lin Chuang,. 2007,10(6):334-337
doi: 10.3969/j.issn.1673-0070.2007.06.003
江思艳, 童九翠, 孙瑞元, 谢海棠 . 复方丹参滴丸治疗冠心病心绞痛Meta分析[J]. 实用药物与临床,. 2007,10(6):334-337
doi: 10.3969/j.issn.1673-0070.2007.06.003
[9] Zhang JH, Shang HC, Gao XM, Wang H, Xiang YZ, Cao HB, Ren M, Dai GH, Mao JY, Zhang BL . Systemic evaluation of Compound Preparation of Salvia miltiorrhiza in treating stable angina in a randomized controlled trial[J]. Tianjin Zhong Yi Yao,. 2007,24(3):195-200
doi: 10.3969/j.issn.1672-1519.2007.03.006
张俊华, 商洪才, 高秀梅, 王辉, 项耀祖, 曹红波, 任明, 戴国华, 毛静远, 张伯礼 . 复方丹参方制剂治疗稳定型心绞痛随机对照试验的系统评价[J]. 天津中医药,. 2007,24(3):195-200
doi: 10.3969/j.issn.1672-1519.2007.03.006
[10] Zhang J, Zhang MZ, Wang L . Systematic review of Compoud Danshen Dripping Pills in treatment of coronary heart disease[J]. Zhongguo She Qu Yi Shi,. 2009,18(6):465-469
张俭, 张敏州, 王磊 . 复方丹参滴丸治疗冠心病的系统评价[J]. 中国社区医师,. 2009,18(6):465-469
[11] Jia Y, Huang F, Zhang S, Leung SW. Is danshen ( Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials. Int J Cardiol. 2011 Jan 18. [Epub ahead of print]
[12] Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ , McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996; 17(1):1-12.
doi: 10.1016/0197-2456(95)00134-4 pmid: 872179710001000
[13] Higgins JTP, Green S . Cochrane handbook for systematic reviews of interventions: Cochrane book series. Chichester: John Wiley and Sons Ltd. 2008.
[14] Begg CB, Mazumdar M . Operating characteristics of a rank correlation test for publication bias[J]. Biometrics, 1994,50(4):1088-1099
doi: 10.2307/2533446 pmid: 7786990
[15] Egger M, Davey Smith G, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test[J]. BMJ, 1997,315(7109):629-634
doi: 10.1136/bmj.315.7109.629
[16] Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement[J]. J Clin Epidemiol, 2009,62(10):1006-1012
doi: 10.1016/j.jclinepi.2009.06.005
[17] Chen JW . Therapeutic observation on the treatment of 62 cases of stable type angina pectoris with Compound Danshen Drop Pills[J]. Zhong Yi Yao Dao Bao,. 2005,11(7):13-14
doi: 10.3969/j.issn.1672-951X.2005.07.006
陈剑威 . 复方丹参滴丸治疗稳定型心绞痛62例疗效观察[J]. 中医药导报,. 2005,11(7):13-14
doi: 10.3969/j.issn.1672-951X.2005.07.006
[18] Fan YL . Effect of compound pills of Danshen root on 130 cases of angina pectoris[J]. Xi Bu Yi Xue,. 2008,20(3):506-508
doi: 10.3969/j.issn.1672-3511.2008.03.020
樊幼林 . 复方丹参滴丸治疗冠心病心绞痛130例临床观察[J]. 西部医学,. 2008,20(3):506-508
doi: 10.3969/j.issn.1672-3511.2008.03.020
[19] Huang ZH . Clinical analysis of Di’ao Xinxuekang capsule in treatment of angina pectoris[J]. Jia Ting Yi Yao Yi Yao Lun Tan,. 2009,1:24-25
黄子辉 . 地奥心血康胶囊治疗冠心病心绞痛的临床分析[J]. 家庭医药(医药论坛),. 2009,1:24-25
[20] Huang YN . Clinical observation of 40 cases of angina pectoris treated with Compound Danshen Dripping Pills[J]. Neimenggu Zhong Yi Yao,. 2007,26(3):5-6
黄应宁 . 复方丹参滴丸治疗冠心病心绞痛40例疗效观察[J]. 内蒙古中医药,. 2007,26(3):5-6
[21] Qin PS, Fan LJ, Liu KY, Xing Y, Zhao SF, Zhu JJ . Clinical investigation on Compound Danshen Dropping Pill for treatment of coronary heart disease — angina pectoris[J]. Zhong Cheng Yao,. 2000,22(9):630-632
doi: 10.3969/j.issn.1001-1528.2000.09.013
秦培森, 范丽娟, 刘克英, 邢燕, 赵淑凤, 朱继军 . 复方丹参滴丸治疗冠状动脉粥样硬化性心脏病心绞痛临床观察[J]. 中成药, 2000,22(9):630-632
doi: 10.3969/j.issn.1001-1528.2000.09.013
[22] Wang D . Clinical observation of Di’ao Xinxuekang in treating angina pectoris of blood stagnation type[J]. Zhong Yi Yao Xue Bao,. 2010,38(2):130-132
王丹 . 地奥心血康软胶囊治疗心血瘀阻型冠心病心绞痛的临床观察[J]. 中医药学报,. 2010,38(2):130-132
[23] Yan L . Prevention and treatment effect of Compound Danshen Dripping Pills in angina pectoris recurrence[J]. Zhong Yi Yao Lin Chuang Za Zhi,. 2007,19(1):9-10
doi: 10.3969/j.issn.1672-7134.2007.01.007
闫良 . 复方丹参滴丸对冠心病心绞痛再发的防治作用[J]. 中医药临床杂志,. 2007,19(1):9-10
doi: 10.3969/j.issn.1672-7134.2007.01.007
[24] Yang M, Zhang CX . Observation of Compound Danshen Dripping Pills in treating angina remission[J]. Zhong Yi Yao Dao Bao,. 2007,4(21):53
杨劢, 张春霞 . 复方丹参滴丸治疗心绞痛缓解期的疗效观察[J]. 中国医药导报,. 2007,4(21):53
[25] Zhang XC.Observation of 50 cases of angina pectoris treated by Compound Danshen Dripping Pills[J].Suzhou Da Xue Xue Bao Yi Xue Ban,. 2002, 22(6): 649, 661
张绪春 .复方丹参滴丸治疗冠心病心绞痛50例疗效观察[J].苏州大学学报( 医学版 ),. 2002, 22(6): 649, 661
[26] Mao B, Wang G, Fan T, Chen XD, Liu J, Wang L, Chang J, Ma JX, Guo J, Fu JJ, Li TQ . Assessing the quality of reporting of randomized controlled trials in traditional Chinese medicine[J]. Zhongguo Xun Zheng Yi Xue Za Zhi,. 2007,7(12):800-887
doi: 10.3969/j.issn.1672-2531.2007.12.010
毛兵, 王刚, 樊涛, 陈小东, 刘佳, 王蕾, 常静, 马建昕, 郭佳, 付娟娟, 李廷谦 . 中医药随机对照试验报告质量评价[J]. 中国循证医学杂志,. 2007,7(12):880-887
doi: 10.3969/j.issn.1672-2531.2007.12.010
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