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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (2): 128-134.doi: 10.3736/jcim20120202

• Review • Previous Articles     Next Articles

Biological research evaluating the Chinese medical theory of the association of the kidney with the ears

Dong Yang,Shi Jian-rong()   

  1. Experimental Teaching Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2011-07-30 Accepted:2011-08-25 Online:2012-02-20 Published:2018-10-09

“Association of the kidney with the ears” is central to the traditional Chinese medical (TCM) theory of the viscera and their manifestations. Previous studies have shown that thyroxin, aldosterone, calcium and iron might be the material basis of the correlation between the kidney and the ears. Due to restriction in research techniques and methods, there has been no further progress in this research field, whose modern biological mechanisms and scientific connotations have not been explained clearly. In recent years, the progress of biological techniques and research on kidney essence provided promising opportunities for research of the association between the kidney and the ears. This article summarized the study progress of “association of the kidney with the ears” theory and posed some meaningful study thoughts. Presbycusis is a kind of degenerative disease caused by aging, which is one aspect of aging of the human body. Because aging is considered as physiological “kidney deficiency”, presbycusis can be regarded as a model of “kidney deficiency” deafness. In conclusion, investigating the correlation between “kidney deficiency” and presbycusis using biotechnology systems combined with “essence of kidney”, should provide a sound basis for study of the theory of the relationship between the kidney and the ears. This will provide new and valuable information for the modern biological research about the theory of visceral associations in TCM.

Key words: visceral manifestation, systems biology, presbycusis, kidney (TCM), ear

[1] Fu WY . The origin and development of "kidney controlling ears" theory in traditional Chinese medicine. Gansu Zhong Yi. 1995; 8(6): 3-6. Chinese.
傅文洋 . 中医肾主耳理论的源流.甘肃中医. 1995; 8(6):3-6.
[2] Luo WF, Guo SR, Cheng SD . Review about the modern research of kidney essence in traditional Chinese medicine. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2001; 7(4): 315-316. Chinese.
罗卫芳, 郭树仁, 程士德 . 中医学肾本质现代研究概述.中国中医基础医学杂志. 2001; 7(4):315-316.
[3] Zeng ZL, Wu DZ, Lu YY . Study on the relationship between “kidney” and ears in traditional Chinese medicine based on experiments. Shanghai Zhong Yi Yao Za Zhi. 1980; ( 1): 2-5, 41. Chinese.
曾兆麟, 吴大正, 陆元元 . 中医“肾”与耳关系的实验研究.上海中医药杂志. 1980; ( 1):2-5, 41.
[4] Zeng ZL, Zhang ML, Hu SM, Zhuang JQ, Wu DZ . The relationship between “kidney” and ears in traditional Chinese medicine based on effect of thyroxin on function of ears. Shanghai Zhong Yi Yao Za Zhi. 1988; ( 9) : 2-4, 10. Chinese.
曾兆麟, 张美莉, 胡寿铭, 庄剑青, 吴大正 . 从甲状腺激素对耳功能的影响看中医“肾”与耳的关系.上海中医药杂志. 1988; ( 9) : 2-4, 10.
[5] Yao X, Rarey KE . Localization of the mineralocorticoid receptor in rat cochlear tissue. Acta Otolaryngol. 1996; 116(3) : 493-496.
doi: 10.3109/00016489609137879 pmid: 8790754
[6] Wangemann P, Kim HM, Billings S, Nakaya K, Li X, Singh R, Sharlin DS, Forrest D, Marcus DC, Fong P . Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression. Am J Physiol Renal Physiol. 2009; 297(5) F1435-F1447.
doi: 10.1152/ajprenal.00011.2009
[7] Hangfu M, Zhao J, Din D . The prophylactic effect of thyroxin on kanamycin ototoxicity in guinea pigs. Hear Res. 1992; 61(1-2):132-136.
doi: 10.1016/0378-5955(92)90043-M pmid: 1526885
[8] Plaza G, Harraiz C . Intratympanic steroids for treatment of sudden hearing loss after failure of intravenous therapy. Otolaryngol Head Neck Surg. 2007 ; 137(1) : 74-78.
doi: 10.1016/j.otohns.2007.01.022
[9] Zhou Y, Zheng H, Shen X, Zhang Q, Yang M . Intratympanic administration of methylprednisolone reduces impact of experimental intensive impulse noise trauma on hearing. Acta Otolaryngol. 2009; 129(6):602-607.
doi: 10.1080/00016480802342424
[10] Shimazaki T, Ichimiya I, Suzuki M, Mogi G . Localization of glucocorticoid receptors in the murine inner ear. Ann Otol Rhinol Laryngol. 2002; 111(12 Pt 1) : 1133-1138.
doi: 10.1177/000348940211101213 pmid: 12498377
[11] Tahera Y, Meltser I, Johansson P, Bian Z, Stierna P, Hansson AC, Canlon B . NF-icB mediated glucocorticoid response in the inner ear after acoustic trauma. J Neurosci Res. 2006; 83(6):1066-1076.
doi: 10.1002/(ISSN)1097-4547
[12] Kim SH, Kim KX, Raveendran NN, Wu T, Pondugula SR, Marcus DC . Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner’s membrane epithelium. Am J Physiol Cell Physiol. 2009; 296(3):C544-C557.
doi: 10.1152/ajpcell.00338.2008
[13] Sun AH, XiaoSZ, Li ZJ, Jiang DS, Li JY, Zhang JF, Xi JH, Zhou YW . Study on the TCM theory of oto- kidney relationship by the changes of microstructure and functions in the iron-deficient rats with kidney-asthenia syndrome. Zhong Yi Yan Jiu. 1993; 6(3): 14-17. Chinese with abstract in English.
孙爱华, 萧轼之, 李兆基, 江德胜, 李津婴, 张锦方, 奚建华, 周毅伟 . 从缺铁肾虚大鼠耳蜗显微结构与生理功能变化探讨肾与耳联系的物质基础.中医研究. 1993; 6(3) : 14-17.
[14] Vilayur E, Gopinath B, Harris DC, Burlutsky G , McMahon CM, Mitchell P. The association between reduced GFR and hearing loss: a cross-sectional population- based study. Am J Kidney Dis. 2010; 56(4):661-669.
doi: 10.1053/j.ajkd.2010.05.015 pmid: 20673695
[15] Xiao J, Luo ZQ . The relationship between kidney diseases and deafness. Guo Ji Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007; 31(6): 351-353. Chinese.
肖娟, 罗志强 . 肾脏疾病与耳聋相关性.国际耳鼻咽喉头颈外科杂志. 2007; 31(6):351-353.
[16] YinLX, Xue LH, Zhang XQ, Liang JF, Ma DC . A study on the relationship between ototoxicity and nephrotoxicity induced by kanamycin. Zhongguo Zhong Xi Yi Jie He Er Bi Yan Hou Ke Za Zhi. 2000; 8(4) : 160-163. Chinese with abstract in English.
印利霞, 薛丽华, 张喜琴, 梁金风, 马栋才 . 卡那霉素耳毒性和肾毒性关系的研究.中国中西医结合耳鼻咽喉科杂志. 2000; 8(4):160-163.
[17] Ding D, McFadden SL, Woo JM, Salvi RJ . Ethacrynic acid rapidly and selectively abolishes blood flow in vessels supplying the lateral wall of the cochlea. Hear Res. 2002; 173(1-2):1-9.
doi: 10.1016/S0378-5955(02)00585-3
[18] Chao YC, Kong WJ, Wang HB, Fan ZM . The difference of mitochondrial DNA 4 834 bp deletion mutation in tissues of inner ear and kidney and skeletal muscle of rat. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008; 22(19): 899-903. Chinese with abstract in English.
朝月臣, 孔维佳, 王海波, 樊兆民 . 大鼠线粒体DNA 4 834 bp缺失突变在内耳和肾及骨骼肌组织中的差异.临床耳鼻咽喉头颈外科杂志. 2008; 22(19):899-903.
[19] Zhong SX, Liu ZH . Expressions of a, p and y subunits of epithelial sodium channel in the cochlea and endolymphatic sac of guinea pig. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009; 44(1) : 49-52. Chinese with abstract in English.
doi: 10.3760/cma.j.issn.1673-0860.2009.01.013
钟时勋, 刘兆华 . 豚鼠耳蜗和内淋巴囊上皮钠通道的表达.中华耳鼻咽喉头颈外科杂志. 2009; 44(1):49-52.
doi: 10.3760/cma.j.issn.1673-0860.2009.01.013
[20] Pitovski DZ, Kerr TP . Sodium- and potassium-activated ATPase in the mammalian vestibular system. Hear Res. 2002; 171(1-2):51-65.
doi: 10.1016/S0378-5955(02)00352-0 pmid: 12204349
[21] Zhu MJ, Tan JS, Li FC, Xu SQ . Analysis on medication regular pattern of 150 prescriptions treating deafness in past dynasties. Hunan Zhong Yi Xue Yuan Xue Bao. 1996; 16(2): 16-17. Chinese.
朱梅菊, 谭敬书, 李凡成, 徐绍勤 . 历代疗耳聋方150 首用药规律分析.湖南中医学院学报. 1996; 16(2):16-17.
[22] Wang DF, Gan ZW, Su CQ, Jiang W . Histopathological study on the protecting effect of golden chamber pill for reinforcing kidney qi on injuries of kidney and ear by gentamicin. Nanjing Zhong Yi Yao Da Xue Xue Bao. 1998; 14(5) : 278-280. Chinese with abstract in English.
王东方, 干祖望, 苏长青, 蒋维 . 金匮肾气丸对庆大霉素肾和耳损害保护作用组织病理学研究.南京中医药大学学报. 1998; 14(5):278-280.
[23] Qiu F, Liu J, Kang SJ, Shi YZ, Shi XJ, Zhang Y . The protective effects of modified Erlongzuociwan on cochlear succinate dehydrogenase. Zhongguo Xin Yao Za Zhi. 2004 ; 13(11) : 991-993. Chinese with abstract in English.
邱芳, 刘洁, 康颂建, 史永芝, 史献君, 张颖 . 加减味耳聋左慈丸对耳蜗琥珀酸脱氢酶的保护作用.中国新药杂志. 2004; 13(11):991-993.
[24] Dong Y, Wang J, Ding DL, Shi JR . Study of serum with Erlong Zuoci Decotion on the gentamicin-induced cochlear hair cells damage. Zhong Yao Yao Li Yu Lin Chuang. 2009; 25(4): 3-5. Chinese with abstract in 30 English.
董杨, 王静, 丁大连, 施建蓉 . 耳聋左慈汤含药血清对庆大霉素致小鼠耳蜗毛细胞损伤的拮抗作用.中药药 31 理与临床. 2009; 25(4):3-5.
[25] DongY, Cao BY, Wang J, Ding DL, Han ZF, Shi JR . Effects of Erlong Zuoci Pill and its disassembled prescriptions on gentamicin-induced ototoxicity model in vitro. Chin J Integr Med. 2010; 16(3):258-263.
doi: 10.1007/s11655-010-0258-x
[26] Wang J, Cao BY, Dong Y, Han ZF, Guo CR, Wang YM, Shi JR . Otoprotectant activities comparison of Shudi and Zexie in different dose proportion on gentamycin induced ototoxic organotypic cultures. Zhonghua Zhong Yi Yao Xue Kan. 2010; 28(3) : 578-582. Chinese with abstract in English.
王静, 曹碧茵, 董杨, 韩志芬, 郭春荣, 王毅敏, 施建蓉 . 熟地泽泻药对配比改变对庆大霉素耳毒性离体细胞模型作用比较.中华中医药学刊. 2010; 28(3):578-582.
[27] Wang J, Guo CR, Dong Y, Jin GQ, Guo RX, Han ZF, Cai XC, Shi JR . Effects of Erlong Zuoci pills and its effective disassembled prescriptions on gentamycin induced hair cell apoptosis. Zhongguo Zhong Yao Za Zhi. 2010; 35(18): 2464-2468. Chinese with abstract in English.
王静, 郭春荣, 董杨, 金国琴, 郭瑞新, 韩志芬, 蔡西晨, 施建蓉 . 耳聋左慈丸及有效拆方拮抗庆大霉素诱导毛细胞凋亡实验研究.中国中药杂志. 2010; 35(18):2464-2468.
[28] Wang YM, Song HY, Tong Z, Qian SJ, Guo RX, Jin ZJ, Shi JR . Effects of Er-Long-Zuo-Ci-Wan on the spontaneous activities of auditory central nucleus in rat model of tinnitus induced by salicylate acid. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 ; 25(3): 397-401. Chinese with abstract in English.
王毅敏, 宋海燕, 童钟, 钱善军, 郭瑞新, 金哲进, 施建蓉 . 耳聋左慈丸对水杨酸耳鸣模型大鼠听中枢神经元放电的影响.中国应用生理学杂志. 2009; 25(3):397-401.
[29] Shen ZY, Chen Y, Huang JH, Liu XY, Zhang XM, Chen WH . Syndrome differentiation through drug effects in mapping the two regulatory pathways of gene networks in shen deficiency syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(6): 521-525. Chinese with abstract in English.
doi: 10.7661/CJIM.2006.6.521
沈自尹, 陈瑜, 黄建华, 刘小雨, 张新民, 陈伟华 . 以药测证绘制肾虚证两大基因网络调控路线图谱.中国中西医结合杂志. 2006; 26(6):521-525.
doi: 10.7661/CJIM.2006.6.521
[30] Charitidi K, Meltser I, Tahera Y, Canlon B . Functional responses of estrogen receptors in the male and female auditory system. Hear Res. 2009; 252(1-2):71-78.
doi: 10.1016/j.heares.2008.12.009 pmid: 19450435
[31] Motohashi R, Takumida M, Shimizu A, Konomi U, Fujita K, Hirakawa K, Suzuki M, Anniko M . Effects of age and sex on the expression of estrogen receptor a and p in the mouse inner ear. Acta Otolaryngol. 2010 ; 130(2) : 204-214.
doi: 10.3109/00016480903016570
[32] Lasisi AO, Fehintola FA, Yusuf OB, Olayemi OO . Correlation between serum immunoglobulin G and hearing threshold among elderly subjects with age-related hearing loss. ORL J Otorhinolaryngol Relat Spec. 2011; 73(2):88-92.
doi: 10.1159/000323830
[33] Li QY, Su SB . Application of systems biology in TCM research. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua. 2008; 10(4): 1-6. Chinese with abstract in English.
doi: 10.11842/wst.2008.2.[sequence]
李青雅, 苏式兵 . 系统生物学在中药复方研究中的应用. 世界科学技术中医药现代化. 2008; 10(4):1-6.
doi: 10.11842/wst.2008.2.[sequence]
[34] Shen ZY, Zhang XM, Lin W, Wu B, Huang JH, Liu XY, Xu XS . Establishment of a quantitative mathematical model of shen-deficiency syndrome based on whole-genome transcriptional profiles. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008; 28(2): 131-134. Chinese with abstract in English.
沈自尹, 张新民, 林伟, 吴斌, 黄建华, 刘小雨, 许世雄 . 基于基因表达谱数据建立肾虚证量化数学模型.中国中西医结合杂志. 2008; 28(2):131-134.
[35] Wu B, Shen ZY, Wang LL, Huang JH, Zhang XM, Liu XY, Xia SJ . Application of nuclear magnetic resonance metabonomic technique in the study on physiological kidney deficiency syndrome. Zhong Yi Za Zhi. 2009 ; 50 (4) : 338-342. Chinese with abstract in English.
吴斌, 沈自尹, 王丽丽, 黄建华, 张新民, 刘小雨, 夏世金 . 应用核磁共振代谢组技术研究生理性肾虚证.中医杂志. 2009; 50(4):338-342.
[36] Gopinath B, Rochtchina E, Wang JJ, Schneider J, Leeder SR, Mitchell P . Prevalence of age-related hearing loss in older adults: Blue Mountains Study. Arch Intern Med. 2009; 169(4) : 415-416.
[37] Lu JB, Zhou RQ, Liu RR, Xue RH . Investigation and analysis of kidney deficiency and patterns in the elderly. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2002 ; 16(1): 22-23. Chinese with abstract in English.
陆金宝, 周如倩, 刘仁人, 薛人华 . 老年人肾虚及其证型的调查研究.上海中医药大学学报. 2002; 16(1):22-23.
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