草药复方Bresol®抵抗化合物48/80诱导的肥大细胞脱颗粒及组胺释放：促使肥大细胞稳定的一种非免疫机制

doi:10.3736/jcim20120614

Abstract

Objective: Present study was aimed to evaluate the protective effect of Bresol ^?, a polyherbal formulation, on mast cell degranulation and histamine release from mast cells.
Methods: Mast cell-stabilizing activity of Bresol^?was evaluated against compound 48/80-induced mast cell degranulation and histamine release from rat peritoneal mast cells in ex vivo conditions.
Results: Microscopy of the control group smears showed more of intact mast cells, with very minimum number of degranulated mast cells and negligible amount of histamine release. In contrast, incubation of mast cells with compound 48/80 caused significant degranulation of the mast cells associated with release of high concentration of histamine in the positive control group. Furthermore, Bresol^? at 100 mg/L showed a significant inhibition of compound 48/80-induced mast cell degranulation. In addition, Bresol^? significantly and dose-dependently inhibited compound 48/80-induced histamine release.
Conclusion: Bresol^? inhibits compound 48/80-induced mast cell degranulation and histamine release in ex vivo conditions. The present findings could be one of the non-immunological mechanism responsible for usefulness of Bresol^? in various allergic conditions.

Key words: medicine, Ayurvedic, plants, medicinal, compound 48/80, mast cells, cell degranulation, histamine release, in vitro

Yathiraj Ashwini, Mohamed Rafiq, Gollapalle L. Viswanatha, Subbanna Rajesh, Selvam Senthilraja, Mohammed Azeemuddin, Suryakanth D. Anturlikar, Paramesh Rangesh, Pralhad S. Patki . Polyherbal formulation Bresol® protects the mast cells against compound 48/80-induced disruption and histamine release: A non-immunological mechanism of mast cell stabilization. Journal of Chinese Integrative Medicine, 2012, 10(6): 690-694.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20120614

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Polyherbal formulation Bresol® protects the mast cells against compound 48/80-induced disruption and histamine release: A non-immunological mechanism of mast cell stabilization

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