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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (7): 738-742.doi: 10.3736/jcim20120703

• Methodology • Previous Articles     Next Articles

How to choose an appropriate experimental design type (Part 2)

Liang-ping Hu(), Xiao-lei Bao, Chen-long Lü#br#   

  1. Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2012-06-05 Accepted:2012-06-17 Online:2012-07-20 Published:2018-07-15
  • Contact: Liang-ping Hu

How to choose an appropriate design type to arrange research factors and their levels is an important issue in scientific research. Choosing an appropriate design type is directly related to the accuracy, scientificness and credibility of a research result. When facing a practical issue, how can researchers choose the most appropriate experimental design type to arrange an experiment based on the research objective and the practical situation? This article mainly introduces the related contents of the design of one factor with two levels and the design of one factor with k (k≥3) levels by analyzing some examples.

Key words: statistics, medical, research design, matched-pair analysis, factor analysis, statistical

[1] Jiang CB, Wang J, Zheng ZX, Hou JS, Ma L, Sun T . Efficacy of cervical fixed-point traction manipulation for cervical spondylotic radiculopathy: a randomized controlled trial[J]. J Chin Integr Med, 2012,10(1):54-58
蒋崇博, 王军, 郑志新, 侯京山, 马玲, 孙彤 . 颈椎定点引伸手法治疗神经根型颈椎病的随机对照研究[J]. 中西医结合学报, 2012,10(1):54-58
[2] Yan GY, Xu ZY, Deng HB, Wan ZY, Zhang L, Zhu JY . Effects of chemotherapy combined with Chinese herbal medicine Kangliu Zengxiao Decoction on tumor markers of patients with advanced non-small-cell lung cancer: a randomized, controlled trial[J]. J Chin Integr Med, 2011,9(5):525-530
严桂英, 徐振晔, 邓海滨, 万智勇, 张磊, 朱娇玉 . 抗瘤增效方联合化疗对中晚期非小细胞肺癌患者肿瘤标志物影响的随机对照研究[J]. 中西医结合学报, 2011,9(5):525-530
[3] Wang SS, Zhai XF, Li B . Effects of cinobufacini injection on contents of serum thyroid-stimulating hormone and adrenaline in rats[J]. J Chin Integr Med, 2009,7(3):228-231
doi: 10.3736/jcim20090306
王双双, 翟笑枫, 李柏 . 华蟾素注射液对大鼠血清促甲状腺素和肾上腺素含量的影响[J]. 中西医结合学报, 2009,7(3):228-231
doi: 10.3736/jcim20090306
[4] Zhang SF, Chen Z, Li B, Chen HY, Ling CQ, Wen XY . Effects of Sisheng Decoction on spontaneous activity and serum concentration of malondialdehyde in mice with yin deficiency sydrome[J]. J Chin Integr Med, 2008,6(10):1029-1033
张素芳, 陈喆, 李柏, 陈红云, 凌昌全, 温新宇 . 四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响[J]. 中西医结合学报, 2008,6(10):1029-1033
[5] Hu LP. The application of statistical triple-type theory in experimental designs[M]. Beijing: People’s Military Medical Press, 2006: 139-165
胡良平 . 统计学三型理论在实验设计中的应用[M]. 北京: 人民军医出版社, 2006: 139-165
[6] Hu LP. Problem-oriented statistics:(1) Research design and statistical foundation[M]. Beijing: People’s Medical Publishing House, 2012: 42-234
胡良平 . 面向问题的统计学——(1)科研设计与统计基础[M]. 北京: 人民卫生出版社, 2012: 42-234
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