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Journal of Integrative Medicine ›› 2015, Vol. 13 ›› Issue (3): 136-139.doi: 10.1016/S2095-4964(15)60172-8

• Commentary • Previous Articles     Next Articles

The methodology flaws in Hinman’s acupuncture clinical trial, Part II: Zelen design and effectiveness dilutions

Arthur Yin Fan   

  1. McLean Center for Complementary and Alternative Medicine, PLC., Vienna, VA 22182, USA
  • Received:2015-02-20 Accepted:2015-03-05 Online:2015-05-10 Published:2015-05-15


Key words: Acupuncture, Chronic knee pain, Hinman, Zelen design, Clinical trial, Statistics, Flaws

[1] Hinman RS, McCrory P, Pirotta M, Relf I, Forbes A, Crossley KM, Williamson E, Kyriakides M, Novy K, Metcalf BR, Harris A, Reddy P, Conaghan PG, Bennell KL . Acupuncture for chronic knee pain: a randomized clinical trial. JAMA, 2014,312(13):1313-1322
doi: 10.1136/acupmed-2014-010727
[2] Fan AY . The methodology flaws in Hinman’s acupuncture clinical trial, Part I: Design and results interpretation. J Integr Med, 2015,13(2):65-68
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[5] Ding Y. Zelen design (Randomized consent design/Prerandomization design). In: The new advance on randomized control trial. Page 23-35. [2015-02-22]. . Chinese.
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[11] White A, Cummings M . Acupuncture for knee osteoarthritis: study by Hinman et al represents missed opportunities. Acupunct Med, 2015,33(1):84-86
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[12] Hinman RS, McCrory P, Pirotta M, Relf I, Crossley KM, Reddy P, Forbes A, Harris A, Metcalf BR, Kyriakides M, Novy K, Bennell KL . Efficacy of acupuncture for chronic knee pain: protocol for a randomized controlled trial using a Zelen design. BMC Complement Altern Med, 2012,12:161
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