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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (5): 343-345.doi: 10.3736/jcim20040510

• Original Clinical Research • Previous Articles     Next Articles

Sputum analysis in patients with "disharmony of stomach"

Ning Chen, Lin Huang, Hui Li, Dian-hong Li, Yu Li   

  1. Department of Internal Medicine, Second Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510095, China
  • Received:2003-08-20 Online:2004-09-20 Published:2018-10-20

Objective: To analyze the amount and inflammatory components of the sputum in patients with "disharmony of stomach", including gastroesophageal reflux disease, peptic ulcer and chronic gastritis.Methods: Sputum production was induced by inspiration of aerosol of 3.5% hypertonic saline with ultrasonic nebulizer, and the total cell count in the sputum was examined. Sputum smear stained with Gimsa was used in differential counting under light microscope. Bacterial culture in the sputum was performed in the usual way. Peak expiratory flow (PEF) was tested to study the airway responsiveness.Results: The amount of sputum, the total cells and eosinophils in the sputum of the patients with "disharmony of stomach" were higher than those of the control. PEF decreased following sputum induction. These parameters returned to control level after treatment with Chinese herbs. Bacterial culture was negative.Conclusion: "Disharmony of stomach" can cause the bronchial inflammation (non-infection) characterized by eosinophil increase.

Key words: disharmony of stomach, sputum, inflammatory cells

CLC Number: 

  • R537

Tab 1

Cell counts in sputum before and after treatment ($\bar{x}$±s )"

Group n Total count
(×107cells/L)
Differential counts(%)
Neutrophil Lymphocyte Mastocyte Eosinophil Monocyte
Control 50 61.3±19.6 32.0±8.7 5.2±1.3 0.3±0.1 2.8±0.7 43.3±10.6
Disharmony of stomach
Before treatment 50 72.4±21.4* * 35.9±9.8 4.9±1.4 0.2±0.1 3.6±1.0* * 40.8±10.7
After treatment 50 58.7±17.1 30.5±8.6 5.0±1.6 0.3±0.1 3.3±0.9 38.7±9.2

Tab 2

Peak expiratory flow before and after sputum inducing ($\bar{x}$±s )"

Group n Peak expiratory flow (L/s)
Before sputum inducing After sputum inducing
Control 50 3.8±1.0 4.0±1.3
Disharmony of stomach
Before treatment 50 3.7±1.2 3.3±0.9* *
After treatment 50 3.8±1.3 3.6±1.1
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