Search JIM Advanced Search

Journal of Integrative Medicine ›› 2021, Vol. 19 ›› Issue (2): 104-110.doi: 10.1016/j.joim.2021.01.007

• Review • Previous Articles     Next Articles

Antifertility and profertility effects of the leaves and seeds of fluted pumpkin: Sperm quality, hormonal effects and histomorphological changes in the testes of experimental animal models

Rex-Clovis C. Njokua, Sunny O. Abarikwub   

  1. a. Department of Chemistry & Molecular Biology, Alex Ekwueme-Federal University, Ndufu-Alike, Ikwo, P.M.B. 1010, Abakaliki, Nigeria
    b. Department of Biochemistry, University of Port Harcourt, Choba, P.M.B. 5323, Port Harcourt, Nigeria
  • Online:2021-03-12 Published:2021-01-24
  • Contact: Sunny O. Abarikwu sunny.abarikwu@uniport.edu.ng E-mail:sunny.abarikwu@uniport.edu.ng

Fluted pumpkin (FP; Telfairia occidentalis) is an edible vegetable, grown in West Africa, that is used in traditional medicine for its regulatory effects on the male gonads. Scientific articles concerning the effects of FP were identified by searching PubMed, PubChem, Scopus, Springer, ResearchGate, Google Scholar and Web of Science; this literature was to better understand the effects of FP seed (FPS) and leaf (FPL) extracts on the testes. Data showed that in experimental animals extracts of FPL and FPS at 1/100 of the lethal dose promoted testis regeneration and improved testosterone concentration and sperm quality, while at higher doses they had antifertility effects. Several extracts of FPS and FPL, including ethanol, aqueous, methanol and hydroethanolic, had protective effects on the testes of study animals at lower doses (≥ 50 mg/kg body weight), but at higher doses (≥ 200 mg/kg body weight) they inhibited hormone synthesis, sperm quality and histomorphological structure, under both normal and disease conditions. The posttreatment effects of FPS on the gonads were reversible in young mature rats and FPS had slight systemic toxic effects. Although, there are inconsistencies in some of the published results, the current evidence suggests that FPS and FPL have both profertility and reversible antifertility effects in experimental animals. 

Key words: Fluted pumpkin, Sperm, Male reproduction, Seeds, Fertility

[1] Xia-qiu Wu, Wendy Satmary, Jin Peng, Ka-kit Hui. Women's preconception health patterns in traditional Chinese medicine as a predictor of fertility outcomes. Journal of Integrative Medicine, 2020, 18(3): 222-228.
[2] Reshma M.Ansari. Potential use of durian fruit (Durio zibenthinus Linn) as an adjunct to treat infertility in polycystic ovarian syndrome. Journal of Integrative Medicine, 2016, 14(1): 22-28.
[3] Dagmar Ehling. Integrative techniques using acupuncture, Chinese herbal medicine, diet, and supplements for polycystic ovary syndrome: A case report. Journal of Chinese Integrative Medicine, 2013, 11(6): 422-427.
[4] Samadder Asmita, Das Jayeeta, Das Sreemanti, Das Durba, De Arnab, Bhadra Kakali, Rahman Khuda-Bukhsh Anisur. Dihydroxy-isosteviol methyl ester of Pulsatilla nigricans extract reduces arsenic-induced DNA damage in testis cells of male mice: Its toxicity, drug-DNA interaction and signaling cascades. Journal of Chinese Integrative Medicine, 2012, 10(12): 1433-1442.
[5] Farzad Rajaei, Nasim Borhani, Fatemeh Sabbagh-Ziarani, Farhad Mashayekhi. Effects of extremely low-frequency electromagnetic field on fertility and heights of epithelial cells in pre-implantation stage endometrium and fallopian tube in mice. Journal of Chinese Integrative Medicine, 2010, 8(1): 56-60.
[6] Zhen-zhi Wang, Chao-qin Yu. Effects of Bushen Huayu Qutan Recipe on local ovarian factors in androgen-sterilized rats. Journal of Chinese Integrative Medicine, 2008, 6(4): 361-365.
[7] Zi-fei Yin, Yu-zhi Hu, Yong-hua Su. Influence of Lithospermum on pregnancy. Journal of Chinese Integrative Medicine, 2007, 5(5): 494-496.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[3] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[4] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[5] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[8] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[9] Ya-hui Liang , Ping Li, Jing-xia Zhao, Xin Liu, Qi-fu Huang. Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1. Journal of Chinese Integrative Medicine, 2010, 8(11): 1060-1069
[10] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079