SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 579-584.doi: 10.3736/jcim20060607

• Original Clinical Research • Previous Articles     Next Articles

Therapeutic effects of Jinqi Jiangtang Tablet on women with polycystic ovary syndrome

Li-hui Hou1,Xin-ming Yang1,Risto Erkkola2,Xiao-ke Wu1   

  1. 1. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province 150040, China
    2. Department of Obstetrics and Gynecology, Turku University Central Hospital, Turku, Finland 20540
  • Online:2006-11-30 Published:2006-11-15

RichHTML

0

PDF (PC)

71

Like

Objective

To observe the therapeutic effects of Jinqi Jiangtang Tablet (JQJTT), a commonly prescribed recipe for type 2 diabetes in traditional Chinese medicine, on obese women with polycystic ovary syndrome (PCOS).

Methods

Twenty-four obese women with PCOS were prescribed JQJTT for 3 months and the changes of carbohydrate metabolism and biochemical indicators, including menstrual cycle, body mass index (BMI), the level of blood sex hormone, area under curve (AUC) of glucose and insulin during oral glucose tolerance test (OGTT), and testosterone responses during human chorionic gonadotrophin stimulation ovary test were observed.

Results

After treatment, there were significantly reductions in BMI (P<0.05), serum glucose level at 30 min during OGTT (P<0.05) and testosterone levels at eighteen hours during human chorionic gonadotrophin stimulation ovary test (P<0.05). In addition, nine patients had improved cycles among sixteen completed patients, and one patient with clomifene resistance got pregnant with response to clomifene treatment.

Conclusion

The beneficial effects of JQJTT may result from improvement of carbohydrate metabolism and reduction in androgen biosynthesis in women with PCOS.

Key words: Polycystic ovary syndrome, Insulin, Blood glucose, Androgen

CLC Number: 

  • R711.75

Table 1

General status before and after treatment (ヌ±S )"

Time;n;BMI (kg/m;2;)WHRLeft ovary volume (ml)Right ovary volume (ml)
Before treatment1628.3±4.320.9±0.217.4±6.515.3±1.2
After treatment1624.6±3.87*0.9±0.115.1±2.714.1±3.8

Table 2

Changes of blood glucose in glycometabolism (ヌ±S , mmol/L)"

Time;n;Blood glucose in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment162.32±1.115.44±4.104.23±1.913.80±2.482.92±2.51
After treatment162.52±1.014.05±1.443.84±2.263.05±1.182.07±1.19
;P;0.756 70.040 00.551 60.262 00.204 9

Table 3

Changes of C-peptide in glycometabolism (nmol/L)"

Time;n;Median of C-peptide in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment161.494.004.004.004.00
After treatment161.864.004.004.001.80
M–100.5–1.52
;P;0.803 6110.45310.3877

Table 4

Changes of insulin in glycometabolism (mU/L)"

Time;n;Median of insulin in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment1615.4259.9258.8338.6929.12
After treatment1612.94110.2293.1869.3422.45
M0.5–2–3–0.5–1
;P;10.45450.210110.8036

Table 5

Changes of glucagon in glycometabolism (ng/L)"

Time;n;Median of glucagon in testing of OGTT
Fasting30 min60 min120 min180 min
Before treatment1650.0050.0050.0066.2450.93
After treatment1650.0052.8050.0051.0750.00
M012.51.51.5
;P;10.75390.17970.54880.5488

Table 6

Comparisons of AUC Insulin, AUC Glucose and insulin sensitivity before and after treatment (ヌ±S )"

Time;n;AUC Insulin (U·L;-1;·min;-1;)AUC Glucose (mg·L;-1;·min;-1;)HOMA-IR
Before treatment16180.80±99.45116.6±46.13.15±3.73
After treatment16227.43±111.2596.2±30.22.37±2.90
;P;0.2190.0730.508

Table 7

Comparisons of reproductive hormones before and after treatment (ヌ±S )"

Time; n;Median
FSH (U/L)LH (U/L)LH/FSHE2 (pmol/L)T (nmol/L)P (nmol/L)PRL (mU/L)
Before treatment146.49.31.51011.41.8331
After treatment1471021361.61.7418
M2.5-3-2-3-1-1-19
;P;0.90.20.10.210.80.3

Table 8

Changes of P in HSOT (ヌ±S , nmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.71±0.561.67±0.581.79±0.701.79±0.792.16±1.122.16±0.98
After treatment142.66±2.831.44±0.441.54±0.631.71±1.512.18±1.352.07±0.90
;P;0.01660.56100.52680.84460.96320.7953

Table 9

Changes of T in HSOT (ヌ±S , nmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.79±0.941.32±0.841.32±0.701.28±0.931.86±0.951.74±0.91
After treatment141.79±1.201.28±0.641.26±0.721.28±0.691.58±1.08*1.49±0.75
;P;0.86950.80130.69800.99010.04930.0960

Table 10

Changes of E2 in HSOT (ヌ±S , pmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment14106.82±41.85112.50±63.85383.33±139.10588.90±271.90552.1±255.32331.35±196.70
After treatment14154.85±87.20121.54±45.90424.76±161.50631.19±211.60574.4±267.20337.90±170.20
;P;0.40.90.50.50.70.9

Table 11

Changes of 17OHP in HSOT ($\bar{x}±S$, μg/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.45±0.461.92±0.782.11±0.932.96±1.673.95±1.763.21±1.54
After treatment141.62±1.221.60±0.761.91±0.762.85±1.384.03±1.803.18±1.71
;P;00.60.50.810.8

Table 12

Changes of A2 in HSOT ($\bar{x}±S$, nmol/L)"

Time;n;Before testingAfter testing
3 h6 h12 h18 h24 h
Before treatment141.34±0.571.59±0.751.68±0.621.14±0.691.02±0.541.03±0.51
After treatment141.21±0.551.55±0.571.91±1.361.07±0.471.05±0.541.07±0.49
;P;0.595 20.880 80.325 90.793 40.892 50.878 2
[1] The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J].Hum Reprod,2004,19(1):41-47
[2] Kopelman PG.Investigation of obesity[J].Clin Endocrino1 (Oxf),1994,41(6):703-708
[3] 李秀钧. 胰岛素抵抗综合征(第1版)[M].北京: 人民卫生出版社,2001,(第1版):60
[4] Legro RS, Castracane VD, Karffman RP.Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls[J].Obstet Gynecol Surv,2004,59(2):141-154
[5] 陈羽, 吕文伟, 雷春利, 等.黄芪皂甙与黄芪多糖对急梗犬心的保护作用及其机制分析[J].中药药理与临床,1994,10(3):12-16
[6] 高从容, 张家庆, 黄庆玲.黄连素增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究[J].中国中西医结合杂志,1997,17(3):162-164
[7] 殷峻, 胡仁明, 唐金凤, 等.小檗碱的体外降糖作用[J].上海第二医科大学学报,2001,21(5):425-427
doi: 10.3969/j.issn.1674-8115.2001.05.012
[8] 周丽斌, 陈名道, 宋怀东, 等.小檗碱对脂肪细胞瘦素和抵抗素基因表达的影响[J].中华内科杂志,2004,43(1):56-57
doi: 10.3760/j.issn:0578-1426.2004.01.022
[9] 吴效科, Erkkola R.胰岛素增敏剂对多囊卵巢综合征患者卵巢局部胰岛素抵抗的影响[J].中华妇产科杂志,2004,39(12):804-808
[1] Tian Fang, Ze-sheng Xue, Jia-xuan Li, Jia-kuan Liu, Di Wu, Mei-qian Li, Yu-ting Song, Shi-feng Yun, Jun Yan. Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by reducing expression of androgen receptor and 5α-reductase in a rat model. Journal of Integrative Medicine, 2021, 19(3): 258-264.
[2] Abdulhakim Abubakar, Abdullahi Balarabe Nazifi, Idris Mohammed Maje, Yusuf Tanko, Joseph Akpojo Anuka, Ezzeldin Mukthar Abdurahman. Antihyperglycaemic activity of ethylacetate extract of Chlorophytum alismifolium in type 2 diabetes: The involvement of peroxisome proliferator-activated receptor-γ and dipeptidyl peptidase-4. Journal of Integrative Medicine, 2021, 19(1): 78-84.
[3] Jafar Abolghasemi, Mohammad Ali Farboodniay Jahromi, Mohammad Hossein Sharifi, Zohreh Mazloom, Leila Hosseini, Nasrindokht Zamani, Majid Nimrouzi. Effects of Zataria oxymel on obesity, insulin resistance and lipid profile: A randomized, controlled, triple-blind trial. Journal of Integrative Medicine, 2020, 18(5): 401-408.
[4] Esmaeil Yousefi Rad, Behzad Nazarian, Somayeh Saboori, Ebrahim Falahi, Azita Hekmatdoost. Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials. Journal of Integrative Medicine, 2020, 18(4): 284-291.
[5] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[6] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
[7] Mehranghiz Ebrahimi-Mameghani, Mohammad Asghari-Jafarabadi, Khatereh Rezazadeh. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine, 2018, 16(5): 329-334.
[8] Uduak Akpan Okon, Idorenyin Udo Umoren. Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model. Journal of Integrative Medicine, 2017, 15(4): 302-309.
[9] Nazli Samadi, Hassan Mozaffari-Khosravi, Masoud Rahmanian, Mohsen Askarishahi. Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: A randomized, double-blind clinical trial. Journal of Integrative Medicine, 2017, 15(2): 124-134.
[10] Jin Yu, Chao-qin Yu, Qi Cao, Li Wang, Wen-jun Wang, Li-rong Zhou, Jing Li, Qiao-hong Qian. Consensus on the integrated traditional Chinese and Western medicine criteria of diagnostic classification in polycystic ovary syndrome (draft). Journal of Integrative Medicine, 2017, 15(2): 102-109.
[11] Qian-wen Ma, Yong Tan. Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome: A meta-analysis. Journal of Integrative Medicine, 2017, 15(2): 95-101.
[12] Qian Zhang, Xin-hua Xiao, Ming Li, Wen-hui Li, Miao Yu, Hua-bing Zhang, Fan Ping, Zhi-xin Wang, Jia Zheng ​. Chromium-containing traditional Chinese medicine, Tianmai Xiaoke Tablet improves blood glucose through activating insulin-signaling pathway and inhibiting PTP1B and PCK2 in diabetic rats. Journal of Integrative Medicine, 2014, 12(3): 162-170.
[13] Dagmar Ehling. Integrative techniques using acupuncture, Chinese herbal medicine, diet, and supplements for polycystic ovary syndrome: A case report. Journal of Chinese Integrative Medicine, 2013, 11(6): 422-427.
[14] Tian-zhan Wang, Yu Chen, Yan-ming He, Xiao-dong Fu, Wang Yi, Yan-qiu Xu, Hong-jie Yang, Hong-li Xue, Yi Liu, Xiao-tao Feng, Teng Zhang, Wen-jian Wang. Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(3): 175-183.
[15] Wen-jian Wang. Enhancing the treatment of metabolic syndrome with integrative medicine. Journal of Chinese Integrative Medicine, 2013, 11(3): 153-156.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3