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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (1): 23-27.doi: 10.3736/jcim20050108

• Original Clinical Research • Previous Articles     Next Articles

Therapeutic effect of Xincang Decoction on chronic airway inflammation in children with bronchial asthma in remission stage

Hui-hua Zhu1,Yan-ping Chen1,Jian-er Yu2,Min Wu3,Zhan Li3   

  1. 1. Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    2. Department of Pediatrics, Shanghai Hospital of Traditional Chinese Medicine, Shanghai, 200071, China
    3. Department of Traditional Chinese Medicine, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China
  • Received:2004-09-22 Online:2005-01-20 Published:2005-01-20
  • Contact: Jian-er Yu E-mail:jianeryu@hotmail.com

Objective

To observe the therapeutic effect of Xincang Decoction on chronic airway inflammation in children with asthma in clinical investigation.

Methods

Xincang Decoction was composed of Flos Magnoliae (Xinyi) and Fructus Xanthii (Cang'erzi), the traditional Chinese herbs for expelling wind. Sixty cases of children with bronchial asthma in remission stage were randomly divided into two groups. Thirty cases in the treatment group were treated with Xincang Decoction and the others in the control group were treated with ketotifen fumarate. The therapeutic effects of the two groups were compared, and the peripheral eosinophil (EOS) count, the levels of immunoglobulin E (IgE), interleukin 4 (IL-4) and interleukin 5 (IL-5), and the pulmonary functions were observed before and three months after the treatment.

Results

After three months treatment, the results showed that the total response rates of the treatment and the control group were 83.3% and 80.0%, respectively, without marked difference (P>0.05). The levels of EOS and IL-5 were obviously decreased after the treatment, and the levels of EOS and IL-5 of the patients in the treatment group were lower than those in the control group (P<0.05). Meanwhile the forced expiratory volume in one second (FEV1) was improved after the treatment, and the FEV1 of the patients in the treatment group was higher than that of the patients in the control group (P<0.05).

Conclusion

Xincang Decoction can decrease the levels of EOS and IL-5 and improve the pulmonary function in treating chronic airway inflammation in children with bronchial asthma in remission stage.

Key words: Asthma,bronchial, Xincang Decoction, Traditional Chinese medical therapy

CLC Number: 

  • R289.5

Tab 1

Comparison of therapeutic effects of 2 groups Cases (%)"

Group n Clinical control Marked effect Effect Failure Total response rate
Treatment 30 6 (20.0%) 11 (36.7%) 8 (26.7%) 5 (16.7%) 25 (83.3%)
Control 30 4 (13.3%) 9 (30.0%) 11 (36.7%) 6 (20.0%) 24 (80.0%)

Tab 2

Comparison of main signs and symptoms integralaverage scores of 2 groups ($\bar{x}$±s)"

Group n Integral average score
Treatment
Before treatment 30 32.83±9.54
After treatment 30 13.87±5.48**
Control
Before treatment 30 32.73±11.54
After treatment 30 9.77±7.19**

Tab 3

Comparison of blood EOS, IgE, IL-4 and IL-5 of 2 groups ($\bar{x}$±s)"

Group n EOS (×109/L) IgE (kU/L) IL-4 (ng/L) IL-5 (ng/L)
Treatment
Before treatment 30 0.95±0.51 108.61±24.04 130.06±67.18 155.07±45.54
After treatment 30 0.38±0.12** 61.68±24.20** 108.65±56.58 73.33±23.28**
Control
Before treatment 30 0.74±0.35 96.66±40.58 118.98±75.90 143.09±35.27
After treatment 30 0.39±0.18** 63.51±32.65** 109.44±70.85 87.67±39.11**

Tab 4

Comparison of pulmonary functions of 2 groups ($\bar{x}$±s)"

Group n FEV1 (L) PEF (L/s) FEF25-75 (L/s)
Treatment
Before treatment 30 1.06±0.42 2.40±0.94 2.15±0.16
After treatment 30 1.50±0.49** 3.24±0.96** 2.23±0.63
Control
Before treatment 30 1.35±1.17 2.48±1.08 2.24±0.03
After treatment 30 1.38±0.41 3.07±1.14** 1.95±0.86
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