慢性乙型肝炎患者血清和胃黏膜乙型肝炎病毒与肝胃不和证的关系

doi:10.3736/jcim20050107

Abstract

Objective

To study the relationship between the infection of hepatitis B virus (HBV) in gastric mucosa and the syndrome of disharmony between liver and stomach.

Methods

Subjects were divided into 2 groups: 30 patients with chronic hepatitis B (CHB) and the syndrome of disharmony between liver and stomach in hepatitis group, and 30 patients with chronic gastritis and the syndrome of disharmony between liver and stomach in gastritis group. Liver function and the markers of HBV were detected. The contents of HBV-DNA in serum and in gastric mucosa were assayed respectively by fluorescence quantitative polymerase chain reaction (FQ-PCR).

Results

(1) The incidence of gastric mucosal lesion in hepatitis group was up to 96.7% (29/30). (2) Scores of the syndrome of disharmony between liver and stomach in hepatitis group were significantly lower than those in gastritis group (P<0.05). The positive rates of HBV-DNA in serum, gastric fundus, body and antrum were 56.7%, 76.7%, 76.7% and 70.0%, respectively. (3) A positive correlation was found not only among the content of HBV-DNA in serum and the contents of HBV-DNA in gastric mucosa (r=0.66-0.94, P< 0.01), but also among the contents of HBV-DNA in serum, gastric mucosa and the total score of the syndrome of disharmony between liver and stomach in hepatitis group (r=0.36-0.52, P<0.05).

Conclusion

The infection of HBV is involved in the syndrome of disharmony between liver and stomach. Gastric mucosal lesion is universal in CHB patients with the syndrome of disharmony between liver and stomach.

Key words: Chronic hepatitis B, Chronic gastritis, Syndrome of disharmony between liver and stomach, Hepatitis B virus

CLC Number:

R512.62

Jin-yu Xia, Yao-yong Zhou, You-yun Zhao. Relationship between hepatitis B virus in gastric mucosa and syndrome of disharmony between liver and stomach in patients with chronic hepatitis B. Journal of Chinese Integrative Medicine, 2005, 3(1): 19-22.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20050107

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References 8

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Liver function	n	Content of HBV-DNA
Liver function	n	Serum	Gastric antrum	Gastric body	Gastric fundus
Mildly abnormal	21	3.06±1.82	4.16±1.45	4.01±1.50	4.44±1.76
Moderately abnormal	9	4.61±2.07	4.91±1.63*	4.92±1.66	5.13±1.84*

Liver function	n	Score
Liver function	n	Distention or movable pain in hypochondrium and stomach	Eructation or hiccup	Gastric upset and acid regurgitation	Irritability	Taut pulse	Total
Mildly abnormal	21	1.67±0.73	1.05±1.12	1.24±1.18	1.81±1.29	2.14±0.91	7.90±2.23
Moderately abnormal	9	1.22±0.44	1.78±1.48	1.11±1.05	1.67±1.22	2.33±1.00	8.11±2.20

Group	n	Score
Group	n	Distention or movable pain in hypochondrium and stomach	Eructation or hiccup	Gastric upset and acid regurgitation	Irritability	Taut pulse	Total
Gastritis	30	2.20±1.00	2.60±1.25	1.67±1.18	1.63±1.35	2.37±0.89	10.47±3.15
Hepatitis	30	1.53±0.68**	1.27±1.26**	1.20±1.13	1.77±1.25	2.20±0.93	7.97±2.19**

Relationship between hepatitis B virus in gastric mucosa and syndrome of disharmony between liver and stomach in patients with chronic hepatitis B

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