Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (8): 747-749.doi: 10.3736/jcim20100803

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Investigative strategy for research on biological basis of traditional Chinese medicine syndrome: feature selection-based data mining methods

Chen Jian-xina,Zhao Hui-huib,Wang Weib   

  1. a Information Center, Beijing University of Chinese Medicine, Beijing 100029, China
    b Department of Postgraduate, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2010-05-19 Accepted:2010-06-11 Online:2010-08-20 Published:2010-08-15

This paper is devoted to discussing two research patterns of biological basis of traditional Chinese medicine syndrome and presenting a research strategy for data mining methods. It points out that data mining methods which are based on feature selection are better fit for investigating biological basis of traditional Chinese medicine syndrome. Based on such a discussion, the concept of “characteristic pattern” is proposed to bridge the gap between “golden index” and biological basis of traditional Chinese medicine syndrome. This paper presents a novel research avenue for investigating biological basis of traditional Chinese medicine syndrome.

Key words: Syndrome, Biology, Information systems, Methodology

[1] Scientific Research Group of Encephalopathy Emergency of State Administration of Traditional Chinese Medicine. Diagnostic criteria for syndrome differentiation of stroke(trial implementation)[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 1994,17(3):64-66
国家中医药管理局脑病急症科研组. 中风病辨证诊断标准[J]. 北京中医药大学学报, 1994,17(3):64-66
[2] Wang J, Li J, Yao KW, Zhong JB . Study on syndrome elements and their combination laws in patients with angina pectoris[J]. Zhong Yi Za Zhi, 2007,48(10):920-922
doi: 10.3321/j.issn:1001-1668.2007.10.025
王阶, 李军, 姚魁武, 衷敬柏 . 冠心病心绞痛证候要素与应证组合研究[J]. 中医杂志, 2007,48(10):920-922
doi: 10.3321/j.issn:1001-1668.2007.10.025
[3] Auffray C, Chen Z, Hood L . Systems medicine: the future of medical genomics and healthcare[J]. Genome Med, 2009,1(1):2
doi: 10.1186/gm2 pmid: 19348689
[4] Li S, Zhang NB, Li ZH, Ding H, Ye YA . Decision tree diagnostic model of gan-dan damp-heat syndrome and gan-stangnancy pi-deficiency syndrome in patients with chronic hepatitis B[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2009,29(11):993-996
doi: 10.3321/j.issn:1003-5370.2009.11.008
李梢, 张宁波, 李志红, 丁皓, 叶永安 . 慢性乙型肝炎患者肝胆湿热证和肝郁脾虚证的决策树诊断模型初探[J]. 中国中西医结合杂志, 2009,29(11):993-996
doi: 10.3321/j.issn:1003-5370.2009.11.008
[5] Guo SZ, Chen JX, Zhao HH, Wang W, Yi JQ, Liu L, Qi QJ, Liu RQ, Qiu Q, Wang Y . Building and evaluating an animal model for syndrome in traditional Chinese medicine in the context of unstable angina(myocardial ischemia) by supervised data mining approaches[J]. J Biol Syst, 2009,17(4):531-546
doi: 10.1142/S0218339009003022
[6] Salazar-Ciudad I, Jernvall J . A computational model of teeth and the developmental origins of morphological variation[J]. Nature, 2010,464(7288):583-586
doi: 10.1038/nature08838 pmid: 20220757
[1] Zeinab Vafaeipour, Bibi Marjan Razavi, Hossein Hosseinzadeh. Effects of turmeric (Curcuma longa) and its constituent (curcumin) on the metabolic syndrome: An updated review. Journal of Integrative Medicine, 2022, 20(3): 193-203.
[2] Shu-yi Chen, Qun-wei Chen, Liu-mei Shou, Hong Pan, Shan-ming Ruan, Zhe-hao Liang, Qi-jin Shu. Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report. Journal of Integrative Medicine, 2021, 19(6): 555-560.
[3] Liang Ding, Xin-you Zhang, Di-yao Wu, Meng-ling Liu. Application of an extreme learning machine network with particle swarm optimization in syndrome classification of primary liver cancer. Journal of Integrative Medicine, 2021, 19(5): 395-407.
[4] Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[5] Shu-jun Wei, Qing-man He, Qing Zhang, Kang-hua Fu, Ruo-lan Li, Wei Peng, Yong-xiang Gao. Traditional Chinese medicine is a useful and promising alternative strategy for treatment of Sjogren's syndrome: A review. Journal of Integrative Medicine, 2021, 19(3): 191-202.
[6] Si-qi Tang, Yun-liang Wang, Zi-ye Xie, Yang Zhang, Yi Guo, Kang-li Gao, Tang-you Mao, Chun-e Xie, Jun-xiang Li, Xiao-yan Gao. Serum metabolic profiling of traditional Chinese medicine syndromes in patients with diarrhea-predominant irritable bowel syndrome. Journal of Integrative Medicine, 2021, 19(3): 274-281.
[7] Dastan M. Khoshnaw, Abhijit A. Ghadge. Yoga as a complementary therapy for metabolic syndrome: A narrative review. Journal of Integrative Medicine, 2021, 19(1): 6-12.
[8] Johannes Loeser, Brigitte Layer, Christopher Plata, Klaus-Maria Perrar, Tim Hucho, Rebecca Kulbida. Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis. Journal of Integrative Medicine, 2020, 18(5): 425-433.
[9] . External application of two unrestricted herbal medicines to treat costochondritis in a young collegiate athlete: A case report. Journal of Integrative Medicine, 2020, 18(5): 450-454.
[10] Shi-xin Wang, Yan Wang, Yu-bao Lu, Jie-yun Li, Yu-jun Song, Munkhtuya Nyamgerelt, Xue-xi Wang. Diagnosis and treatment of novel coronavirus infectious pneumonia based on the theory of traditional Chinese medicine. Journal of Integrative Medicine, 2020, 18(4): 275-283.
[11] Zi-jia Zhang, Wen-yong Wu, Jin-jun Hou, Lin-lin Zhang, Fei-fei Li, Lei Gao, Xing-dong Wu, Jing-ying Shi, Rong Zhang, Hua-li Long, Min Lei, Wan-ying Wu, De-an Guo, Kai-xian Chen, Lewis A. Hofmann, Zhonghua Ci. Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: network-molecular docking-LC-MSE analysis. Journal of Integrative Medicine, 2020, 18(3): 229-241.
[12] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[13] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[14] Rebecca Kulbida, Alexander Mathes, Johannes Loeser. Beneficial effects of hirudotherapy in a chronic case of complex regional pain syndrome. Journal of Integrative Medicine, 2019, 17(5): 383-386.
[15] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
Full text



[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239