癌痛的中医药治疗

doi:10.3736/jcim20110202

Abstract

Pain is one of the common symptoms of cancer which seriously affects the quality of life of the patients. Cancer pain is mainly treated with the three-step method, biological therapy or nerve block therapy based on antitumor therapy. However, up to 50 percent of patients with cancer-related pain do not receive adequate pain relief, affecting their physical and psychological well-being, and leading to a lower quality of life for the patient after conventional treatment. Clinical observation suggests that traditional Chinese medicine may alleviate cancer-related pain either by oral administration, topical administration, acupuncture or other means with continuing non-addictive and non-drug-resistant qualities. However, scientific evaluation of the efficacy of herbs in the treatment of pain is insufficient; the underlying mechanisms are unclear and, safety and toxicity remain a concern.

Key words: cancer pain, traditional Chinese medicine, treatment, review

Ju-yong Wang, Ling Xu, Rui-xin Zhang, Lixing Lao. Traditional Chinese medicine for cancer pain. Journal of Chinese Integrative Medicine, 2011, 9(2): 129-134.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20110202

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References 40

[1]	Radha Krishna LK, Poulose JV, Tan BS, Goh C . Opioid use amongst cancer patients at the end of life[J]. Ann Acad Med Singapore, 2010,39(10):790-797 doi: 10.1097/MAJ.0b013e3181ebd715 pmid: 21063640
[2]	Schaffer D, Florin T, Eagle C, Marschner I, Singh G, Grobler M, Fenn C, Schou M, Curnow KM . Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review[J]. Med J Aust, 2006,185(9):501-506
[3]	Ameringer S . Barrier to pain management among adolescents with cancer[J]. Pain Manag Nurs, 2010,11(4):224-233 doi: 10.1016/j.pmn.2009.05.006 pmid: 21095597
[4]	Xu L, Lao LX, Ge A, Yu S, Li J, Mansky PJ . Chinese herbal medicine for cancer pain[J]. Integr Cancer Ther, 2007,6(3):208-234 doi: 10.1177/1534735407305705 pmid: 17761635
[5]	Du YQ, Wang QQ, Liu J, Ha MLT . Compound Chinese herb for cancer pain: a systematic review[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2010,10(6):707-710
	杜业勤, 王庆全, 刘晶 , 哈木拉提·吾甫尔.中药复方治疗癌性疼痛的系统评价[J]. 中国循证医学杂志, 2010,10(6):707-710
[6]	Deng L, Du XY, Jiang YL . Progress in clinical research of traditional Chinese medicine in treatment of cancer pain[J]. Hunan Zhong Yi Za Zhi, 2007,23(6):85-87 doi: 10.3969/j.issn.1003-7705.2007.06.054
	邓兰, 杜小艳, 蒋益兰 . 中医药治疗癌性疼痛的临床研究进展[J]. 湖南中医杂志, 2007,23(6):85-87 doi: 10.3969/j.issn.1003-7705.2007.06.054
[7]	Zhou DH. Clinical traditional Chinese medicine oncology[M]. Beijing: People’s Medical Publishing House, 2003: 70
	周岱翰 . 临床中医肿瘤学[M]. 北京: 人民卫生出版社, 2003: 70
[8]	Liu MX . Modified Shaoyao Gancao decoction in treatment of advanced cancer pain: a report of 42 cases[J]. Guo Yi Lun Tan, 2005,20(5):5-6 doi: 10.3969/j.issn.1002-1078.2005.05.005
	刘明霞 . 芍药甘草汤加味治疗中晚期癌症疼痛42例[J]. 国医论坛, 2005,20(5):5-6 doi: 10.3969/j.issn.1002-1078.2005.05.005
[9]	Peng HY, Zhang YH, Wang RP, Cai MM . Clinical observation of Xaiotong decoction in treatment of cancer pain[J]. Sichuan Zhong Yi, 2003,21(12):46 doi: 10.3969/j.issn.1000-3649.2003.12.030
	彭海燕, 章永红, 王瑞平, 蔡明明 . 消痛方治疗癌性疼痛的临床观察[J]. 四川中医, 2003,21(12):46 doi: 10.3969/j.issn.1000-3649.2003.12.030
[10]	Han X . Xiaozhong Sanzheng decoction in treatment of cancer pain: a report of 99 cases[J]. Xin Zhong Yi, 2007,39(4):95-96 doi: 10.3969/j.issn.0256-7415.2007.04.062
	韩旭 . 消肿散癥汤治疗癌性疼痛99例[J]. 新中医, 2007,39(4):95-96 doi: 10.3969/j.issn.0256-7415.2007.04.062
[11]	Wei L, Yang CG, Miao WH . Observation of the efficacy and safety of Tianchan capsule in the treatment of cancer pain[J]. Zhongguo Xin Yao Za Zhi, 2003,12(8):663-665
	魏琳, 杨晨光, 苗文红 . 天蟾胶囊治疗癌性疼痛Ⅱ期临床研究[J]. 中国新药杂志, 2003,12(8):663-665
[12]	Chen GY, Liu YQ, Gao P, Tai YH . Clinical research on treatment of 25 cases of cancerous pain with pain-relieving capsule of Chinese medicine[J]. Jiangsu Zhong Yi Yao, 2005,26(1):16-17 doi: 10.3969/j.issn.1672-397X.2005.01.005
	陈高阳, 刘延庆, 高鹏, 邰亚宏 . 中药止痛胶囊治疗癌性疼痛25例临床研究[J]. 江苏中医药, 2005,26(1):16-17 doi: 10.3969/j.issn.1672-397X.2005.01.005
[13]	Tian HQ, Huang ZQ, Liang GW, Chen WJ . Ailitong gel in treatment of cancer pain: a report of 60 cases[J]. Shaanxi Zhong Yi, 2004,25(3):232-235
	田华琴, 黄志庆, 梁贵文, 陈卫军 . 癌理通外敷治疗癌性疼痛60例[J]. 陕西中医, 2004,25(3):232-235
[14]	Sun JF, Lu LJ, Zang JH, Jing ZH . Clinical observation of Tongshu gel in treatment of cancer pain[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2006,13(1):56
	孙金芳, 芦连菊, 臧建华, 荆振海 . 痛舒膏外敷治疗癌性疼痛临床观察[J]. 中国中医药信息杂志, 2006,13(1):56
[15]	He JG . Treatment of 33 cases of bone metastasis cancer pain with Zhitong plaster and radiotherapy[J]. Shandong Zhong Yi Za Zhi, 2005,24(1):20-21
	和劲光 . 中药止痛膏配合放射治疗癌性骨转移疼痛33例[J]. 山东中医杂志, 2005,24(1):20-21
[16]	Yu S, Wei PK, Qin ZF, Xu L . Treatment of 40 cases of cancer pain with Tongluo Sanjie plaster[J]. Zhong Yi Za Zhi, 2006,47(6):465
	俞珊, 魏品康, 秦志丰, 许玲 . 通络散结酊外用治疗癌性疼痛40例[J]. 中医杂志, 2006,47(6):465
[17]	Yang RL, Qu PL . Chinese herbal medicine local coated in treatment of cancer pain[J]. Zhong Liu Fang Zhi Za Zhi, 2000,7(2):174
	杨瑞利, 曲培莲 . 中药局部外搽治疗癌性疼痛[J]. 肿瘤防治杂志, 2000,7(2):174
[18]	Lu Y, Zhang ZJ, Lu YX, Liang NS, Yang F, Li Y, Liang AM . Clinical study on Xiangshu Zhitong Ding in treating cancerous pain[J]. Shi Zhen Guo Yi Guo Yao, 2007,18(1):58-59 doi: 10.3969/j.issn.1008-0805.2007.01.029
	陆益, 张作军, 陆益线, 梁宁生, 杨帆, 李艳, 梁安民 . 香术止痛酊外治癌性疼痛的临床研究[J]. 时珍国医国药, 2007,18(1):58-59 doi: 10.3969/j.issn.1008-0805.2007.01.029
[19]	Peng H, Peng HD, Xu L, Lao LX . Efficacy of acupuncture in treatment of cancer pain: a systematic review[J]. J Chin Integr Med, 2010,8(6):501-509
	彭浩, 彭海东, 许玲, 劳力行 . 针刺治疗癌痛疗效的系统综述[J]. 中西医结合学报, 2010,8(6):501-509
[20]	Sun YL, Yu LR . Observation on therapeutic effect of needle-retaining method of triple puncture in 80 cases of pain due to hepatic cancer[J]. Zhongguo Zhen Jiu, 2000,20(4):211-212
	孙亚林, 于连荣 . 齐刺留针法治疗肝癌疼痛80例疗效观察[J]. 中国针灸, 2000,20(4):211-212
[21]	Jin ZX . Clinical analysis of two-phase acupuncture-moxibustion therapy for large intestine cancer in 27 cases[J]. Shanghai Zhong Yi Yao Za Zhi, 2003,37(5):48-49
	金哲秀 . 针灸两步法治疗大肠癌27例临床分析[J]. 上海中医药杂志, 2003,37(5):48-49
[22]	Hu X, Ling CQ, Zhou QH . Clinical observation on wrist-ankle acupuncture for treatment of pain of middle-late liver cancer[J]. Zhongguo Zhen Jiu, 2004,24(3):149-151
	胡侠, 凌昌全, 周庆辉 . 腕踝针治疗中晚期肝癌疼痛的临床观察[J]. 中国针灸, 2004,24(3):149-151
[23]	Schwei MJ, Honore P, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, Clohisy DR, Mantyh PW . Neurochemical and cellular reorganization of the spinal cord in a mufine model of bone cancer pain[J]. J Neurosci, 1999,19(24):10886-10897 doi: 10.1523/JNEUROSCI.19-24-10886.1999
[24]	Wacnik PW, Eikmeier LJ, Ruggles TR, Ramnaraine ML, Walcheck BK, Beitz AJ, Wilcox GL . Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain[J]. J Neurosci, 2001,21(23):9355-9366 doi: 10.1523/JNEUROSCI.21-23-09355.2001
[25]	Medhurst SJ, Walker K, Bowes M, Kidd BL, Glatt M, Muller M, Hattenberger M, Vaxelaire J , O’Reilly T , Wotherspoon G , Winter J , Green J, Urban L .A rat model of bone cancer pain[J]. Pain, 2002,96(1-2):129-140 doi: 10.1016/S0304-3959(01)00437-7 pmid: 11932069
[26]	Goblirsch MJ, Zwolak P, Clohisy DR . Advances in understanding bone cancer pain[J]. J Cell Biochem, 2005,96(4):682-688 doi: 10.1002/jcb.20589 pmid: 16149079
[27]	Zhang RX, Liu B, Wang L, Ren K, Qiao JT, Berman BM, Lao L . Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia[J]. Pain, 2005,118(1-2):125-136 doi: 10.1016/j.pain.2005.08.001
[28]	Martin CD, Jimenez-Andrade JM, Ghilardi JR, Mantyh PW . Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain[J]. Neurosci Lett, 2007,427(3):148-152 doi: 10.1016/j.neulet.2007.08.055
[29]	Sabino MC, Ghilardi JR, Feia KJ, Jongen JL, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ, De Filipe C, Mantyh PW . The involvement of prostaglandins in tumorigenesis, tumor-induced osteolysis and bone cancer pain[J]. J Musculoskelet Neuronal Interact, 2002,2(6):561-562
[30]	Kingsley LA, Fournier PG, Chirgwin JM, Guise TA . Molecular biology of bone metastasis[J]. Mol Cancer Ther, 2007,6(10):2609-2617 doi: 10.1158/1535-7163.MCT-07-0234 pmid: 17938257
[31]	Boyle WJ, Simonet WS, Lacey DL . Osteoclast differentiation and activation[J]. Nature, 2003,423(6937):337-342 doi: 10.1038/nature01658
[32]	Kinder M, Chislock E, Bussard KM, Shuman L, Mastro AM . Metastatic breast cancer induces an osteoblast inflammatory response[J]. Exp Cell Res, 2008,314(1):173-183 doi: 10.1016/j.yexcr.2007.09.021 pmid: 17976581
[33]	Yamamoto J, Kawamata T, Niiyama Y, Omote K, Namiki A . Down-regulation of muopioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain[J]. Neuroscience, 2008,151(3):843-853 doi: 10.1016/j.neuroscience.2007.11.025
[34]	Urch CE, Donovan-Rodriguez T, Dickenson AH . Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain[J]. Pain, 2003,106(3):347-356 doi: 10.1016/j.pain.2003.08.002 pmid: 14659517
[35]	Li XQ, Miao XR, Yu WF . Progresses of molecular mechanisms underlying cancer pain[J]. Guo Ji Ma Zui Xue Yu Fu Su Za Zhi, 2007,28(2):146-149 doi: 10.3760/cma.j.issn.1673-4378.2007.02.015
	李晓青, 缪雪蓉, 俞卫锋 . 癌症痛分子机制的研究进展[J]. 国际麻醉学与复苏杂志, 2007,28(2):146-149 doi: 10.3760/cma.j.issn.1673-4378.2007.02.015
[36]	Deng B, Jia LQ, Gao FY, Li H, Ye XL, Xu CL . Research of Huayu Zhitong decoction in treatment of bone destruction caused by metastatic carcinoma[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 2010,16(11):145-146
	邓博, 贾立群, 高福云, 李环, 叶晓兰, 许灿龙 . 化瘀止痛方对骨转移癌骨质破坏影响的研究[J]. 中国实验方剂学杂志, 2010,16(11):145-146
[37]	Liu Y, Li Z, Bai H, Zhang YY . Study on the effect of Zhentong Plaster in external use on the alleviation of cancer pain and its mechanism[J]. Zhong Yi Xue Bao, 2010,25(4):611-615
	刘耀, 李忠, 白桦, 张雅月 . 镇痛膏外用缓解癌性疼痛的作用及相关机制研究[J]. 中医学报, 2010,25(4):611-615
[38]	Mao-Ying QL, Cui KM, Liu Q, Dong ZQ, Wang W, Wang J, Sha H, Wu GC, Wang YQ . Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain[J]. Eur J Pain, 2006,10(8):689-694 doi: 10.1016/j.ejpain.2005.11.001 pmid: 16376128
[39]	Zhang RX, Li A, Liu B, Wang L, Ren K, Qiao JT, Berman BM, Lao L . Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model[J]. Anesth Analg, 2007,105(5):1482-1488 doi: 10.1213/01.ane.0000284705.34629.c5
[40]	Zhang RX, Li A, Liu B, Wang L, Xin J, Ren K, Qiao JT, Berman BM, Lao L . Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model[J]. Eur J Pain, 2008,12(7):870-878 doi: 10.1016/j.ejpain.2007.12.006

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Traditional Chinese medicine for cancer pain

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