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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (1): 48-53.doi: 10.3736/jcim20120108

• Original Clinical Research • Previous Articles     Next Articles

Effects of acupuncture at Shenmen (HT7) or Taiyuan (LU9) on P3a and P3b of event-related potentials in healthy young adults

Cai Rong-lin1,Hu Ling1(),Wu Zi-jian1,Wang Ke-ming1,He Lu1,Zhou Yi-ping1,Zhao Lun2,Hu Wu-bin1   

  1. 1. Institute of Acupuncture and Moxibustion, Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China
    2. Laboratory of EEG/ERP, Beijing Fistar Technology Co., Ltd., Beijing 100097, China
  • Received:2011-06-28 Accepted:2011-07-31 Online:2012-01-20 Published:2018-09-21
  • Contact: Hu Ling

OBJECTIVE: To investigate the effects of manual acupuncture at Shenmen (HT7) or Taiyuan (LU9) on the attention function of the brain, and to lay an experimental foundation for researching brain function and integration mechanisms of the human brain in relation to acupuncture stimulation.METHODS: Ten healthy young college students were selected as experimental subjects. P3a and P3b potentials were induced by novel stimulation and target stimulation with vision and were observed using Neuroscan event-related potentials system at time windows of ms 330-430 or 400-600 ms for observing the change of intensity distribution of P300 after manual acupuncture at HT7 or LU9.RESULTS: The amplitude of P3a and P3b decreased significantly after manual acupuncture at HT7 or LU9, but the degree of decreases affected by the acupoints was different. The decrease of the amplitude of P3a due to acupuncture at HT7 was more significant than acupuncture at LU9 (P<0.05).CONCLUSION: The attention function of the brain is affected by manual acupuncture at HT7 or LU9 and manual acupuncture at HT7 has a greater influence on the attention function of the brain.

Key words: acupuncture points, event-related potentials, P300, Shenmen (HT7), Taiyuan (LU9), human experimentation

Figure 1

Examples of visual stimulation in experimentA: non-target stimulation; B: target stimulation; C: novel stimulation."

Figure 2

Flow diagram of the trial"

Figure 3

The waveform characteristics of ERP with superposed averageA: Raw EEG; B: EEG segments and averaged ERP waveform. P1, N1, P2, N2 and P3 in graph represent the various waveform components respectively. ERP: event-related potential; EEG: electroencephalogram."

Figure 4

Total average of ERPs induced by different conditionsAxis of ordinates represents amplitude (μV) of the P3b or P3a and axis of abscissa represents the time window (ms) of analysis. The amplitudes are superposed average data of all stimulation. A: P3b of target stimulation; B: P3a of navel stimulation. ERP: event-related potential."

Table 1

P3a and P3b amplitudes before and after acupuncture at different acupoints in subjects($\bar{x}$±s, μV)"

Group n P3a amplitute P3b amplitude
Fz FCz Cz Cz CPz Pz
HT7 Before acupuncture 8 3.6±1.1 6.8±1.3 5.1±1.4 6.5±1.6 7.2±1.8 8.8±2.1
After acupuncture 8 2.0±0.9** 2.4±1.0** 2.1±1.2** 4.4±1.4** 5.8±1.7** 6.4±1.4**
LU9 Before acupuncture 8 4.8±1.3 5.3±1.2 3.9±1.3 8.7±1.9 8.9±2.2 9.1±2.1
After acupuncture 8 3.4±1.0* 3.5±1.0** 2.6±1.1* 6.5±1.8** 7.3±2.0* 7.9±1.6*
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