Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (1): 48-53.doi: 10.3736/jcim20120108

• Original Clinical Research • Previous Articles     Next Articles

Effects of acupuncture at Shenmen (HT7) or Taiyuan (LU9) on P3a and P3b of event-related potentials in healthy young adults

Cai Rong-lin1,Hu Ling1(),Wu Zi-jian1,Wang Ke-ming1,He Lu1,Zhou Yi-ping1,Zhao Lun2,Hu Wu-bin1   

  1. 1. Institute of Acupuncture and Moxibustion, Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China
    2. Laboratory of EEG/ERP, Beijing Fistar Technology Co., Ltd., Beijing 100097, China
  • Received:2011-06-28 Accepted:2011-07-31 Online:2012-01-20 Published:2018-09-21
  • Contact: Hu Ling E-mail:hulingtcm@126.com

OBJECTIVE: To investigate the effects of manual acupuncture at Shenmen (HT7) or Taiyuan (LU9) on the attention function of the brain, and to lay an experimental foundation for researching brain function and integration mechanisms of the human brain in relation to acupuncture stimulation.METHODS: Ten healthy young college students were selected as experimental subjects. P3a and P3b potentials were induced by novel stimulation and target stimulation with vision and were observed using Neuroscan event-related potentials system at time windows of ms 330-430 or 400-600 ms for observing the change of intensity distribution of P300 after manual acupuncture at HT7 or LU9.RESULTS: The amplitude of P3a and P3b decreased significantly after manual acupuncture at HT7 or LU9, but the degree of decreases affected by the acupoints was different. The decrease of the amplitude of P3a due to acupuncture at HT7 was more significant than acupuncture at LU9 (P<0.05).CONCLUSION: The attention function of the brain is affected by manual acupuncture at HT7 or LU9 and manual acupuncture at HT7 has a greater influence on the attention function of the brain.

Key words: acupuncture points, event-related potentials, P300, Shenmen (HT7), Taiyuan (LU9), human experimentation

Figure 1

Examples of visual stimulation in experimentA: non-target stimulation; B: target stimulation; C: novel stimulation."

Figure 2

Flow diagram of the trial"

Figure 3

The waveform characteristics of ERP with superposed averageA: Raw EEG; B: EEG segments and averaged ERP waveform. P1, N1, P2, N2 and P3 in graph represent the various waveform components respectively. ERP: event-related potential; EEG: electroencephalogram."

Figure 4

Total average of ERPs induced by different conditionsAxis of ordinates represents amplitude (μV) of the P3b or P3a and axis of abscissa represents the time window (ms) of analysis. The amplitudes are superposed average data of all stimulation. A: P3b of target stimulation; B: P3a of navel stimulation. ERP: event-related potential."

Table 1

P3a and P3b amplitudes before and after acupuncture at different acupoints in subjects($\bar{x}$±s, μV)"

Group n P3a amplitute P3b amplitude
Fz FCz Cz Cz CPz Pz
HT7 Before acupuncture 8 3.6±1.1 6.8±1.3 5.1±1.4 6.5±1.6 7.2±1.8 8.8±2.1
After acupuncture 8 2.0±0.9** 2.4±1.0** 2.1±1.2** 4.4±1.4** 5.8±1.7** 6.4±1.4**
LU9 Before acupuncture 8 4.8±1.3 5.3±1.2 3.9±1.3 8.7±1.9 8.9±2.2 9.1±2.1
After acupuncture 8 3.4±1.0* 3.5±1.0** 2.6±1.1* 6.5±1.8** 7.3±2.0* 7.9±1.6*
[1] Shang SY, You CJ. Application and research progress of cognitive potential P300. Zhongguo Kang Fu. 2008; 23(2):133-135. Chinese.
doi: 10.3870/j.issn.1001-2001.2008.02.031
尚淑怡, 尤春景 . 认知电位P300的应用及研究进展. 中国康复. 2008; 23(2):133-135.
doi: 10.3870/j.issn.1001-2001.2008.02.031
[2] Zhu H , Zhang JJ. Clinical applications of event-related P3a and P3b in cognitive evaluation. Zhongguo Lin Chuang Shen Jin Ke Xue. 2008; 16(1):94-98. Chinese with abstract in English.
朱虹, 章军建 . 事件相关电位P3a和P3b在认知功能评测中的临床应用.中国临床神经科学. 2008; 16(1):94-98.
[3] CaiRL, Hu L, Zhou YP, Wu ZJ, Wang KM, Tang XM, Li M, Li ZH. Effects of electroacupuncture of “Shenmen”( HT7) and “Zhizheng” ( SI7) on cardiac function and electrical activities of cardiac sympathetic nerve in acute myocardial ischemia rabbits. Zhen Ci Yan Jiu. 2007 ; 32(4):243-246. Chinese with abstract in English.
doi: 10.3969/j.issn.1000-0607.2007.04.006
蔡荣林, 胡玲, 周逸平, 吴子建, 汪克明, 唐晓敏, 李梦, 李姿慧 . 电针对急性心肌缺血家兔心功能及心交感神经电活动的影响.针刺研究. 2007; 32(4):243-246.
doi: 10.3969/j.issn.1000-0607.2007.04.006
[4] Ou XF, Pan SY, Huang Y , Ji XB. Correlation study on event-related potentials P300 and cognition. Zhongguo Lao Nian Xue Za Zhi. 2010; 30(6):833-836. Chinese.
欧小凡, 潘速跃, 黄英, 纪新博 . 事件相关电位P300与认知相关研究.中国老年学杂志. 2010; 30(6):833-836.
[5] Squires NK, Squires KC, Hillyard SA . Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol. 1975; 38(4) : 387-401.
doi: 10.1016/0013-4694(75)90263-1 pmid: 46819
[6] Restuccia D, Della Marca G, Marra C, Rubino M, Valeriani M . Attentional load of the primary task influences the frontal but not the temporal generators of mismatch negativity. Cogn Brain Res. 2005; 25(3):891-899.
doi: 10.1016/j.cogbrainres.2005.09.023
[7] Harrison JB, Buchwald JS, Kaga K, Woolf NJ, Butcher LL . “Cat P300” disappears after septal lesions. Electroencephalogr Clin Neurophysiol. 1988; 69(1):55-64.
doi: 10.1016/0013-4694(88)90035-1 pmid: 2448121
[8] Polich J, Criado JR . Neuropsychology and neuropharmacology of P3a and P3b. Int J Psychophysiol. 2006; 60(2) : 172-185.
doi: 10.1016/j.ijpsycho.2005.12.012 pmid: 16510201
[9] Dong HT , Bai Y. Clinical research of the influence of cognizing potential on AD patients by electro-acupuncture treatment. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003; 19(1):94-96. Chinese with abstract in English.
doi: 10.3969/j.issn.1000-6834.2003.01.023
董洪涛, 白英 . 电针治疗老年性痴呆对其认知电位影响的临床研究.中国应用生理学杂志. 2003; 19(1):94-96.
doi: 10.3969/j.issn.1000-6834.2003.01.023
[10] Xu P, Jiang YP, Wang Y , Lu GH. Influence of acupuncture on heroin addicts attentional bias. Shanghai Zhong Yi Yao Za Zhi. 2006; 40(3):40-41. Chinese with abstract in English.
doi: 10.3969/j.issn.1007-1334.2006.03.023
徐平, 姜迎萍, 王岩, 陆光华 . 针刺对海洛因依赖者认知注意偏向的影响.上海中医药杂志. 2006; 40(3):40-41.
doi: 10.3969/j.issn.1007-1334.2006.03.023
[11] Zhang QM, Yu RY, Pang J, Zhou YF, Zhou Y , Jin R. Acupuncture induced changes of the event related potential P3 latency and wave amplitude in autistic children with language disorder. Zhongguo Lin Chuang Kang Fu. 2005; 9(20):10-11. Chinese with abstract in English.
张全明, 余瑞英, 庞坚, 周雅芳, 周茵, 靳瑞 . 针刺引起孤独症语言障碍儿童事件相关电位P3潜伏期和波幅的变化.中国临床康复. 2005; 9(20):10-11.
[12] Liu J. Study on the relation between mind disease and meridians in Huangdi’s Classic of Internal Medicine. Beijing: Beijing University of Chinese Medicine. 2008 : 95-98. Chinese with abstract in English.
刘霁 . 《黄帝内经》神志病证及其与经脉关系的研究.北京:北京中医药大学. 2008: 95-98.
[1] Yan Guan , Hui Zhang, Wei Zhang, Shi-bing Su . Analysis of differential gene expression profile in peripheral blood of patients with chronic hepatitis B and syndromes of dual deficiency of liver and kidney yin and accumulation of dampness heat. Journal of Chinese Integrative Medicine, 2012, 10(7): 751-756.
[2] Hui-jiao Liang , Zhen-jiao Liang , Xiao-ping Wang. Three-dimensional reconstruction of the Lung Meridian of Hand-Taiyin with continuous thin-section CT image. Journal of Chinese Integrative Medicine, 2012, 10(12): 1400-1404.
[3] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271.
[4] Se-Der Wu, Jen-Tzer Gau, Yuh-Hai Wang. Ryodoraku as a tool monitoring the effects of walking exercise. Journal of Chinese Integrative Medicine, 2011, 9(12): 1319-1325.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[5] Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[8] Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017
[9] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[10] Ya-bing Zhou, Jian-er Yu, Jie Wu, Li Bai, Li-li Huo, Xin-guang Zhang, Li-qing Li . Effects of Chinese herbal medicine Bushen Gubiao Recipe on toll-like receptor 4 and CD4 +CD25 +foxp3 +regulatory T cells in mice with recurrent respiratory tract infections. Journal of Chinese Integrative Medicine, 2010, 8(11): 1053-1059