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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 24-26.doi: 10.3736/jcim20040109

• Original Clinical Research • Previous Articles     Next Articles

Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients

Wei-ning Zhang1, Ye ZHANG2, Jia-bang Li3   

  1. 1. Depar tment of Internal Medicine, Futian Distr ict Hospital of Tr aditional Chinese Medicine, Shenzhen , Guangdong Province 518034 , China;
    2. Depar tment of Obstet rics Gynecology , First Affiliated Hospital , Hunan College of Tr aditional Chinese Medicine , Changsha , Hunan Province 410007 , China
    3. Institute of Integra ted T raditional Chinese and Western Medicine,Xiangya Hospital , Cent ral South Unive rsity , Changsha , Hunan Province 410008 , China
  • Online:2004-01-20 Published:2018-10-25

Objective: To observe the effect of Jianwei Yuyang Granules on the expression of epidermal growth factor receptor (EGFR) in the gastric mucosa of gastric ulcer patients. Methods: Sixty gastric ulcer patients (final diagnosis by gastroscope) were randomly divided into Jianwei Yuyang Granules treated group (JWYY group, n=30) and western medicine treated group (control group, n=30). Ten patients without gastric mucosa lesion were treated as normal control group. The expression of EGFR in the mucosa was tested by immunohistochemistry and RT-PCR. Results: Expression of EGFR and EGFR mRNA was not observed in patients without gastric mucosa lesion, and slight expression was observed in the edge of ulcer region of the gastric ulcer patients. The expression of EGFR and EGFR mRNA was increased in JWYY group and control group.Conclusion: Jianwei Yuyang Granules enhances the expression of EGFR in the mucosa of gastric ulcer patients to prevent peptic ulcer recurrence.

Key words: Jianwei Yuyang Granules, stomach ulcer, epidermal growth factor receptor

CLC Number: 

  • R573.11

Tab 1

Changes of EGFR expression in 3 groups (positiverate) by immunohistochemical method (ヌ±S)"

Group n Before treatment After treatment
Treatment group 30 3.9±2.0△△ 15.4±3.2**
Control group 24 3.6±2.1△△ 15.8±2.5**
Normal group 10 1.5±1.2 -

Tab 2

Changes of EGFR mRNA expression in 3groups(EGFR/β-actin) (ヌ±S)"

Group n Before treatment After treatment
Treatment group 30 0.046±0.032△△ 0.201±0.038**
Control group 24 0.058±0.028△△ 0.187±0.037**
Normal group 10 0.021±0.017 -
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