氯沙坦与卡维地洛合参麦注射液治疗老年缺血性心脏病心衰41例临床观察

doi:10.3736/jcim20030427

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R541.6

Jing-li Chi, Xu-tao Sui, Shang-ai Li, Jing Li. Clinical observation of 41 cases of senile ischemic heart disease treated by losarton, carvadilol and Shenmai Injection. Journal of Chinese Integrative Medicine, 2003, 1(4): 317-318.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20030427

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[2]	Pitt B, Segal R, Martinez FA , et al. Randomized trial of losartan versus captopril in patients over 65 with heart failure[J]. Lancet, 1997,349(9054):747-752 doi: 10.1016/S0140-6736(97)01187-2
[3]	Kabour A, Henegar JR, Devineni VR , et al. Prevention of angiotensin Ⅱ induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat[J]. Cardiovasc Res, 1995,29(4):543-548 doi: 10.1016/S0008-6363(96)88532-4
[4]	Basu S, Senior R, Raval U , et al. Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomized trial[J]. Circulation, 1997,96(1):183-191 doi: 10.1161/01.CIR.96.1.183
[5]	Brunvand H, Kvitting PM, Rynning SE , et al. Carvedilol protects against lethal reperfusion injury through antiadrenergic mechanisms[J]. Cardiovasc Pharmacol, 1996,28(3):409-417 doi: 10.1097/00005344-199609000-00010 pmid: 8877588
[6]	Yue TL, Cheng HY, Lysko PG , et al. Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger[J]. J Pharmacol Exp Ther, 1992,263(1):97-98

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项目	治疗组(n=41)		对照组(n=39)
项目	治疗前	治疗后	治疗前	治疗后
心率（次/min）	84 ± 13	70 ± 10△	86 ± 14	79 ± 12
收缩压(mmHg)	128 ± 16	120 ± 13	130 ± 18	126 ± 15
舒张压(mmHg)	76 ± 9	70 ± 8	80 ± 11	78 ± 10
LVEF(%)	76 ± 9	54 ± 8**^△	39 ± 5	45 ± 8
E/A比值	0.76 ± 0.27	1.39 ± 0.34**^△	0.79 ± 0.20	1.01 ± 0.31
心肌耗氧量(HR×SBP)	10.839 ± 2 660	8.236±1 480**^△	11.294±3 048	10.120±2 500

Clinical observation of 41 cases of senile ischemic heart disease treated by losarton, carvadilol and Shenmai Injection

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