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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (1): 25-29.doi: 10.3736/jcim20030111

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Clinical observation of the curative effect of Qiangxin Mixture on congestive heart failure

Zhao-shan Chen1(), Yao-rong Dong1, Wan-ying Hu2   

  1. 1. Department of Cardiovasology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071, China
    2. Department of Cardiology,Shuguang Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai 200021, China
  • Received:2003-03-01 Online:2003-03-20 Published:2018-10-19


To investigate the efficacy of Qiangxin Mixture in patients with congestive heart failure (CHF).


Sixty cases of CHF were randomly divided into Qiangxin Mixture group (treatment group,n=30) and digoxin group (control group, n=30).The total clinical effective rate,integra of the symptoms of kidney deficiency, classification of functional capacity of the NewYork Heart Association (NYHA), and echocardiogram[ejection fraction (EF), cardiac output (CO), interventricular septal thickness (IVST), posterior wall thickness (PWT), left ventricular mass index (LVMI)] as well as the measurement of plasma endothelin, angiotensin II and atrial natriuretic peptide were observed in both groups.


The total clinical effective rate of Qiangxin Mixture group was 87%, and improvement was significantly observed in the Lee CHF score, classification of functional capacity of the NYHA, EF and CO(P<0.05,vs before treatment),but no significant improvement in digoxin group (P>0.05). The integra of the symptoms of kidney deficiency, the levels of plasma ET, Ang II and ANP decreased significantly (P<0.01) vs before treatment and digoxin group respectively). IVST,PWT and LVMI were also reduced significantly(P <0.01)vs before treatment;P<0.05 vs digoxin group).


The Qiangxin Mixture is effective in enhencing cardiac contraction,improving hemodynamics in the short-term and rectifying some indexes in the long-term,so it could postpone the processes of CHF. This mechanism may be related to decreasing the stimulating factors (angiotensin, endothelin) which trigger the cardiac remodeling, delaying or reversing the cardiac remodeling.

Key words: Qiangxin Mixture, congestive heart failure, cardiac remodeling, endothelin, angiotensin II, atrial natriuretic peptide

CLC Number: 

  • R541.61


组别 例数(N) 病程
($\bar{x}$±s,年 )
性别 年龄
($\bar{x}$±s,岁 )
男(n 女(n Ⅲ级(n Ⅳ级(n
治疗组 30 5.5±4.9 10 20 69.5±8.2 26 4
对照组 30 5.2±4.1 12 18 69.9±8.6 27 3


组别 例数(N) 高心病(n 冠心病(n 风心病(n 扩张性心肌病(n 其他(n
治疗组 30 11 10 5 3 1
对照组 30 8 14 2 4 2


组别 例数 (N) 显效 有效 无效 总有效率
n % n % n % n %
治疗组 30 14 47 12 40 4 13 26 87
对照组 30 11 37 13 43 6 20 24 80


组别 治疗前 治疗后
治疗组 6.24±1.25 4.35±1.16**
对照组 6.09±1.32 4.61±1.47**


治疗前 治疗后
治疗组 7.35±2.44 4.17±1.98**△△
对照组 7.52±2.23 7.71±2.36


治疗前 对照后
治疗组 0.583±0.054 0.552±0.063*
对照组 0.575±0.047 0.579±0.036


治疗组 对照组
治疗前 治疗后 治疗前 治疗后
EF 41.90±4.30 45.10±3.80* 41.50±4.40 44.80±4.70*
FS 22.60±2.70 26.80±3.10* 21.70±3.50 25.60±4.00*
SV 41.30±5.60 47.30±4.90* 40.20±4.50 46.70±5.10*
CO 2.70±0.40 3.10±0.30* 2.50±0.30 3.20±0.50*
TVST 11.26±1.35 10.31±1.41** 11.17±1.29 10.95±1.03
PWT 10.75±0.97 10.03±1.06** 10.90±1.22 10.64±1.14
LVMI 154.80±17.30 142.50±13.20** 157.50±14.60 152.10±15.90


治疗组 对照组
治疗前 治疗后 治疗前 治疗后
ET(ng/L) 95.60±23.3 57.20±18.7**△△ 100.90±31.4 93.80±27.1
ANP(μg/L) 0.57±0.11 0.32±0.13**△△ 0.62±0.14 0.45±0.15*
AngII(ng/L) 189.10±38.5 126.50±29.3**△△ 204.70±33.6 1 860.20±38.1
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