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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (3): 268-272.doi: 10.3736/jcim20090313

• Literature Research • Previous Articles     Next Articles

Dose-response patterns of Radix Glycyrrhizae in Shanghan Lun

 Xue Yanga, Xiang-liang Kongb, Xiao-qiang Yuea   

  1. a Department of Classics, School of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China
    b Department of Treatise on Febrile Diseases, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2008-11-12 Accepted:2009-01-07 Online:2009-03-20 Published:2009-03-15

In order to explore the dose-response patterns of Gancao (Radix Glycyrrhizae) in Shanghan Lun (Treatise on Febrile Diseases), all prescriptions containing Gancao in Shanghan Lun were analyzed by frequency and hierarchical clustering analysis. The doses of Gancao used in Shanghan Lun ranged from six zhu (Chinese unit, and one zhu is equal to 0.65 g) to four liang (Chinese unit, and one liang is equal to 15.625 g). Doses of one, two, three or four liang were commonly used. One liang Gancao as juvantia was usually matched with Mahuang (Herba Ephedrae), Xingren (Semen Armeniacae) and Guizhi (Ramulus Cinnamomi) for restricting the excessive diaphoresis of Mahuang. Two liang Gancao was often matched with some couple drugs, such as Guizhi and Shaoyao (Radix Paeoniae), Shigao (Gypsum Fibrosum) and Zhimu (Rhizoma Anemarrhenae), Fuzi (Radix Aconiti Lateralis) and Ganjiang (Rhizoma Zingiberis), for warming yang to supplement qi, nourishing yin, detoxifying Fuzi, and preventing qi impairment from heat evil. Three liang Gancao was mainly matched with Banxia (Rhizoma Pinelliae) or Renshen (Radix Ginseng) for treating middle energizer emesis. Four liang Gancao was matched with Ganjiang or tonifying herbs for invigorating vital qi and relieving spasm in deficiency syndromes with contraction, palpitation or diarrhea. Gancao is used for treating many syndromes in Shanghan Lun. It is frequently used to treat excess or heat syndromes with one or two liang in a dose and deficiency or cold syndromes with three or four liang in a dose.

Key words: Shanghai Lun , Radix Glycyrrhizae, Compatibility, Dose-response relationship, Drug

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甘草用量 方剂名称(方次) 合计方数(方次)
6铢 麻黄升麻汤(1) 1 (1)
1两 麻黄汤(9) 茯苓甘草汤(2) 桂枝麻黄各半汤(1) 6 (15)
柴胡桂枝汤(1) 柴胡加芒硝汤(1) 栀子柏皮汤(1)
1两2铢 桂枝二麻黄一汤(1) 桂枝二越婢一汤(1) 2(2)
2两 桂枝汤(19) 桂枝甘草龙骨牡蛎汤(1) 桂枝附子汤(1) 45 (92)
四逆汤(11) 桂枝去桂加茯苓白术汤(1) 茯苓四逆汤(1)
调胃承气汤(8) 桂枝救逆汤(1) 甘草附子汤(1)
白虎加人参汤(5) 桂枝新加汤(1) 当归四逆汤(1)
白虎汤(3) 葛根黄芩黄连汤(1) 桃核承气汤(1)
桂枝加厚朴杏子汤(2) 桂枝加芍药汤(1) 甘草汤(1)
葛根汤(2) 桂枝去芍药汤(1) 桔梗汤(1)
大青龙汤(2) 麻黄附子甘草汤(1) 黄芩汤(1)
麻杏甘石汤(2) 桂枝去芍药加附子汤(1) 竹叶石膏汤(1)
小建中汤(2) 当归四逆加吴茱萸生姜汤(1) 四逆加人参汤(1)
通脉四逆汤(2) 厚朴生姜半夏甘草人参汤(1) 桂枝甘草汤(1)
桂枝加大黄汤(1) 黄芩加半夏生姜汤(1) 葛根加半夏汤(1)
茯苓桂枝白术甘草汤(1) 通脉四逆加猪胆汁汤(1) 白术附子汤(1)
茯苓桂枝甘草大枣汤(1) 麻黄连轺赤小豆汤(1) 桂枝加桂汤(1)
桂枝加葛根汤(1) 柴胡桂枝干姜汤(1) 栀子甘草豉汤(1)
3两 小柴胡汤(13) 小青龙汤(2) 理中丸(2) 9(23)
桂枝加附子汤(1) 黄连汤(1) 芍药甘草附子汤(1)
生姜泻心汤(1) 半夏泻心汤(1) 旋覆代赭汤(1)
4两 甘草干姜汤(1) 桂枝人参汤(1) 甘草泻心汤(1) 5(5)
芍药甘草汤(1) 炙甘草汤(1)
等分 半夏散及汤(1) 四逆散(1) 2(2)

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[1] Qian CH, Hao WS. Necessarily serial for clinic of traditional Chinese medicine: Shang Han Lun[M]. Beijing: People’s Medical Publishing House,2005
钱超尘, 郝万山 . 中医临床必读丛书·伤寒论[M]. 北京: 人民卫生出版社,2005
[2] Ke XF. Serial of modern research and application of traditional Chinese medicine: Shang Han Lun and Jin Gui Yao Lue[M]. Shanghai: Shanghai University of Traditional Chinese Medicine Press,1995
柯雪帆 . 现代中医药应用与研究大系·伤寒与金匮[M]. 上海: 上海中医药大学出版社,1995
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