Indomethacin,Curcumin,Acemetacin,Bioavailability,Damage,Gastrointestinal,Side effect,Drugs, Chinese herbal," /> Indomethacin,Curcumin,Acemetacin,Bioavailability,Damage,Gastrointestinal,Side effect,Drugs, Chinese herbal,"/> Evidence against the participation of a pharmacokinetic interaction in the protective effect of single-dose curcumin against gastrointestinal damage induced by indomethacin in rats
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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (2): 151-157.doi: 10.1016/S2095-4964(17)60324-8

• Research Article • Previous Articles     Next Articles

Evidence against the participation of a pharmacokinetic interaction in the protective effect of single-dose curcumin against gastrointestinal damage induced by indomethacin in rats

Liliana Zazueta-Beltrána, Lorena Medina-Aymericha, Nadia Estela Díaz-Tristea, Aracely Evangelina Chávez-Piñab, Gilberto Castañeda-Hernándeza, Leticia Cruz-Antonioc   

  1. a Department of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, 07360 Mexico City, Mexico 
    b Laboratory of Pharmacology, Institutional Program in Molecular Biomedicine, National School of Medicine and Homeopathy of the National Polytechnic Institute, Academic Area of Medicine of the Institute of Health Sciences, 07320 Mexico City, Mexico 
    c Superior Studies Faculty of Zaragoza, Universidad National Autonomous of Mexico, 09230 Mexico City,Mexico
  • Received:2016-09-09 Accepted:2016-12-06 Online:2017-03-15 Published:2017-03-15
  • Contact: Leticia Cruz-Antonio, PhD; E-mail: letycruza@yahoo.com.mx

Objective

To determine the role of a pharmacokinetic interaction in the protective effect of curcumin against the gastric damage induced by indomethacin administration as such or as its prodrug acemetacin.

Methods

Wistar rats orally received single dose of indomethacin (30 mg/kg) with and without curcumin (30 mg/kg); gastric injury was evaluated by determining the total damaged area. Additional groups of rats received an oral single dose of indomethacin (30 mg/kg) or its prodrug acemetacin (34.86 mg/kg) in the presence or absence of curcumin (30 mg/kg). Indomethacin and acemetacin concentrations in plasma from blood draws were determined by high-performance liquid chromatography. Plasma concentration-against-time curves were constructed, and bioavailability parameters, maximal concentration (Cmax) and area under the curve to the last sampling time (AUC0-t) were estimated.

Results

Concomitant administration of indomethacin and curcumin resulted in a significantly reduced gastric damage compared to indomethacin alone. However, co-administration of curcumin did not produce any significant alteration in the bioavailability parameters of indomethacin and acemetacin after administration of either the active compound or the prodrug.

Conclusion

Curcumin exhibits a protective effect against indomethacin-induced gastric damage, but does not produce a reduction of the bioavailability of this nonsteroidal anti-inflammatory drug, indomethacin. Data thus suggest that a pharmacokinetic mechanism of action is not involved in curcumin gastroprotection.

Key words: Indomethacin, Curcumin, Acemetacin, Bioavailability, Damage, Gastrointestinal, Side effect, Drugs, Chinese herbal

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