银杏外种皮多糖胶囊制剂治疗中晚期上消化道恶性肿瘤的临床研究

doi:10.3736/jcim20030313

Abstract

Objective

To observe the clinical efficacy of Ginkgo biloba exocarp polysaccharides (GBEP) capsule preparation in treating upper digestive tract malignant tumors of middle and late stage.

Methods

Eighty-six patients of the upper digestive tract malignant tumors were treated with GBEP capsule preparation taken orally. The clinical symptoms and the qualities of life of the patients with single GBEP and combined with operation, radiotherapy or intervention chemotherapy were observed. The tumor size was measured by electronic gastroscope before and after treatment with single GBEP. Objective response rate (RR) of the tumor was calculated. The survival period of patient was observed. The changes of blood routine examination in the patients treated with radiotherapy were observed.

Results

GBEP preparation could markedly improve the patients' clinical symptoms. Karnofsky scoring of the patients markedly increased after treatment. There were 2 CR (complete response, 6.3%), 22 PR (partial response, 68.8%) and 5 SD (stable disease, 15.6%) of 32 cases with single GBEP preparation. The survival periods of the 32 cases were markedly prolonged. The preparation could relieve the inhibited hematopietic function and the weight loss due to radiotherapy.

Conclusion

GBEP capsule preparation has some definite therapeutic effects on upper digestive tract malignant tumors of middle and late stage.

Key words: Ginkgo biloba, polysaccharides, digestive system neoplasms, clinical research

CLC Number:

R730.52

Hua-sheng Chen, Fan Zhai, Yun-fei Chu, Fang Xu, Ai-hua Xu, Lin-chang Jia. Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation. Journal of Chinese Integrative Medicine, 2003, 1(3): 189-191.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20030313

http://www.jcimjournal.com/EN/Y2003/V1/I3/189

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症状	治疗前	治疗后
症状	治疗前	症状消失	明显好转	改善	无效
吞咽困难	34	17	14	2	1
癌性疼痛	52	34	13	3	2
脘腹胀满	32	18	8	4	2
呕吐痰涎	24	12	7	4	1
乏力	25	15	6	3	1
失眠	22	8	10	4	0
出血	14	9	4	1	0
纳减	68	2	42	18	6

组别	n	白细胞（×10⁹/L）	红细胞（×10¹²/L）	血红蛋白（g/L）	血小板（×10⁹/L）	体重(kg)
放疗前	34	6.47±2.19	4.09±0.59	120.5±18.9	165.5±77.2	53.8±6.8
放疗后	34	5.32±2.61	4.02±0.33	120.0±14.9	156.6±72.5	53.3±8.1

中医证型	n	完全缓解	部分缓解	稳定	进展	有效率(%)
气滞血瘀型	12	1	9	2	0	83.3
痰湿中阻型	10	1	7	1	1	80.0
脾胃虚弱型	6	0	4	1	1	66.7
气血（阴）双亏型	4	0	2	1	1	50.0
合计	32	2	22	5	3	75.0

Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation

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