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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 187-188.doi: 10.3736/jcim20030312

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Clinical evaluation of integration of transcatheter arterial chemoembolization and traditional Chinese medicine in treating metastatic liver cancer

Zhi-qiang Meng(), Yi-yu Xu, Lu-ming Liu, Ming-zhi Song, Wen-xia Huang   

  1. Department of Traditional Chinese Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China
  • Received:2003-02-15 Online:2003-09-20 Published:2003-09-20


To evaluate the treatment effect, quality of life and side effect of transcatheter arterial chemoembolization (TACE) and traditional Chinese medicine (TCM) in treating metastatic liver cancer.


Thirty nine cases of colon metastatic liver cancer were randomly divided into two groups. Both TACE and TCM were used in the treatment group, while only TACE was used in the control group. The drug used in TACE included floxuridine, pirarubicin, cisplatin, and the herbs for strengthening the spleen and regulating Qi were used in TCM.


The response rate in the treatment group was 30% (45% including minor remission patients), and the median survival time was 18.6 months. While in the control group the response rate was 15.8% (36.8% including minor remission patients), and the median survival time was 14.3 months. The 1-, 2-, 3-year survival rates of treatment group and the control group were 70.2%、40.3%、13.0% and 68.7%、29.5%、10.3% respectively. There were fewer other organ metastases in the treatment group. The score from the EORTC quality of life questionnaire QLQ C30 in treatment group was ligher than that in the control group.


Integration of TACE and TCM in treating colon metastatic liver cancer has better results.

Key words: arterial catheterization, chemoembolization, therapeutic, colonic neoplasms, neoplasm metastasis, drugs, Chinese herbal

CLC Number: 

  • R730.52
[1] August DA, Sugarbaker PH, Ottow R , et al. Hepatic resection of colorectal metastases. Influence of clinical factors and adjuvant intraperitoneal 5 fluorouracil via Tenckhoff catheter on survival[J]. Ann Surg, 1985,201(2):210-218
doi: 10.1097/00000658-198502000-00013
[2] 刘瑛, 刘守业, 许立功 , 等. 大肠癌[A]. 见: 汤钊猷主编. 现代肿瘤学[M]. 上海: 上海医科大学出版社, 1993. 528-530.
[3] Tellez C, Benson AB, Lyster MT , et al. Phase II trail of chemoembolization for the treatment of metastatic colorectal carcinoma to the liver and review of the literature[J]. Cancer, 1998,82(7):1250-1259
doi: 10.1002/(ISSN)1097-0142
[4] Osba D, Rodrigues G, Myles J , et al. Interpreting the significance of changes in health related quality of life scores[J]. J Clin Oncol, 1998,16(1):139-144
doi: 10.1200/JCO.1998.16.1.139 pmid: 9440735
[5] King MT . The interpretation of scores from the EORTC quality of life questionnaire QLQ C30[J]. Qual Life Res, 1996,5(6):555-567
doi: 10.1007/BF00439229
King MT . The interpretation of scores from the EORTC quality of life questionnaire QLQ C30[J]. Qual Life Res, 1996,5(6):555-567
[6] Fayers P, Aaronson N, Bjordal K , et al. EORTC QLQ-C30 scoring manual [M]. EORTC Study Group on Quality of Life, Brussels, Quality of Life Unit, EORTC Data Centre, 1995. 10-20.
[7] 王建平, 陈仲庚, 林文娟 , 等. 中国癌症病人生活质量的测定——EORTC QLQ C30在中国的试用[J]. 心理学报, 2000,32(5):438-442
doi: 10.1007/BF02983513
[8] 曾辉英, 李槐, 史仲华 , 等. 消化道肿瘤肝转移介入治疗的临床疗效[J]. 中华肿瘤杂志, 2000,22(5):422-424
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