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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (12): 1246-1249.doi: 10.3736/jcim20081207

• Original Clinical Research • Previous Articles     Next Articles

Herba Saxifragae cream in treatment of chronic eczema: a randomized controlled trial

Rong Xu, Fu-lun Li, Lin-ling Zhang, Xun Song, Jing-lin Zhu, Bing Li()   

  1. Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2008-06-03 Online:2008-12-20 Published:2008-12-15

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Objective: 

To explore the clinical efficacy of Herba Saxifragae cream (HS), a compound of traditional Chinese herbal medicine, on chronic eczema.


Methods:

A total of 42 cases of chronic eczema were randomly divided into HS group (22 cases) and hydrocortisone (HC) group (20 cases). To the HS group, HS was externally applied twice a day continuously for 4 weeks. To the HC group, hydrocortisone was externally applied twice a day continuously for 4 weeks. The total score of symptom score reducing index (SSRI) was calculated before and after treatment in terms of itching degree, lesion shape and lesion area, in the evaluation of the clinical efficacy of HS on chronic eczema.


Results: 

After 2-week treatment, the total response rate of HS group was 77.3%, and the total response rate of HC group was 70.0%. After 4-week treatment, the total response rates were 86.4% and 85.0% in HS and HC groups respectively. There was no statistical difference in total scores of SSRI between the two groups (P>0.05), and neither was there the difference in the score of itching degree, lesion shape and lesion area (P>0.05).


Conclusion: 

Herba Saxifragae cream has the same effect as hydrocortisone in treating chronic eczema.

Key words: eczema, external application drugs, Herba Saxifragae cream, randomized controlled trials

CLC Number: 

  • R758.23

Table 1

Symptom score before treatment and SSRI after treatment in two groups (x±s)"

Group n Total score
before treatment		 Difference after treatment vs before treatment SSRI score after treatment
2-week 4-week 2-week 4-week
HS 22 108.91±38.23 53.73±21.97 77.18±27.52 0.53±0.19 0.75±0.20
HC 20 106.25±35.46 54.90±26.39 76.55±36.76 0.52±0.19 0.72±0.19

Table 2

Clinical efficacy in two groups"

Group n Cured
[Cases (%)]		 Obvious effect [Cases (%)] Improved
[Cases (%)]		 Failure
[Cases (%)]		 Total response
rate (%)
After 2-week treatment
HS 22 1 (4.5) 3 (13.6) 13 (59.1) 5 (22.7) 77.3
HC 20 1 (5.0) 3 (15.0) 10 (55.0) 6 (30.0) 70.0
After 4-week treatment
HS 22 4 (18.2) 11 (50.0) 4 (18.2) 3 (13.6) 86.4
HC 20 3 (15.0) 10 (50.0) 4 (20.0) 3 (15.0) 85.0
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