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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (2): 126-128.doi: 10.3736/jcim20040215

• Original Experimental Research • Previous Articles     Next Articles

Effects of Shendan Jianyi Capsule on aldose reductase activity of kidney in diabetic rats

Zhao-hui Fang1, Xiao-ping Zhang1, Dao-lin Bao1, Yi Xu1, Le Luo2, Jun Zhou2   

  1. 1. Department of Metabolism and Endocrinology, First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Hefei, Anhui Province 230031, China
    2. School of Life Science, University of Science and Technology of China, Hefei, Anhui Province 230038, China
  • Online:2004-03-20 Published:2018-10-25

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：Objective: To evaluate the effects of Shendan Jianyi Capsule (SDJYC) on aldose reductase (AR) activity of the kidney in diabetic rats and the significance of prevention and treatment of diabetic nephropathy with Chinese natural herbs. Methods: Diabetic Wistar rats were treated with SDJYC and sorbinil respectively, and the AR activity in kidney, urine protein and the activity of Na+-K+-ATPase were tested. Results: The AR activity in diabetic rats was decreased obviously after being treated with sorbinil or SDJYC. The activity of Na+-K+-ATPase in diabetic rats decreased obviously at the end of the eighth week, and increased after being treated with sorbinil and SDJYC. There was no difference between two treated groups after the treatment. It demonstrated that the inhibition of AR activity could improve the activity of Na+-K+-ATPase and SDJYC had the same effect. Conclusions: SDJYC exerts effects by inhibiting the activity of AR .

Key words: diabetic kidney, Shendan Jianyi Capsule, aldose reductase, Na+ K+ ATPase, sorbinil

CLC Number: 

  • R587.24

Tab 1

Comparison of activity of aldose reductase in kidney of 4 groups (ヌ±S)"

GroupnActivity of aldose reductase
NADPH（0.1 mmol/L）NADH（0.1 mmol/L）
Normal group82.12±0.820.40±0.19
Model group810.20±3.86**3.61±1.56
Sorbinil group83.27±0.88△△1.26±0.27△△
SDJYC group83.23±0.79△△0.96±0.14△△

Tab 2

Comparison of changes of urine protein of 4 groups (ヌ±S, mg/L)"

GroupnUrine protein
4th week8th week
Normal group81 623±1 2151 709±956
Model group82 500±2 310**2 810±2 330**
Sorbinil group82 520±2 4802 360±2 120△△
SDJY group82 570±1 9302 170±1 920△△

Tab 3

Comparison of activity of Na+-K+-ATPase of 4 groups (ヌ±S, mmol Pi·g-1 pro·h-1)"

GroupnActivity of Na+-K+-ATPase
Normal group80.58±0.12
Model group80.36±0.17*
Sorbinil group80.48±0.16△
SDJY group80.47±0.18△
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