SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (2): 126-128.doi: 10.3736/jcim20040215

• Original Experimental Research • Previous Articles     Next Articles

Effects of Shendan Jianyi Capsule on aldose reductase activity of kidney in diabetic rats

Zhao-hui Fang1, Xiao-ping Zhang1, Dao-lin Bao1, Yi Xu1, Le Luo2, Jun Zhou2   

  1. 1. Department of Metabolism and Endocrinology, First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Hefei, Anhui Province 230031, China
    2. School of Life Science, University of Science and Technology of China, Hefei, Anhui Province 230038, China
  • Online:2004-03-20 Published:2018-10-25

RichHTML

0

PDF (PC)

58

Like

：Objective: To evaluate the effects of Shendan Jianyi Capsule (SDJYC) on aldose reductase (AR) activity of the kidney in diabetic rats and the significance of prevention and treatment of diabetic nephropathy with Chinese natural herbs. Methods: Diabetic Wistar rats were treated with SDJYC and sorbinil respectively, and the AR activity in kidney, urine protein and the activity of Na+-K+-ATPase were tested. Results: The AR activity in diabetic rats was decreased obviously after being treated with sorbinil or SDJYC. The activity of Na+-K+-ATPase in diabetic rats decreased obviously at the end of the eighth week, and increased after being treated with sorbinil and SDJYC. There was no difference between two treated groups after the treatment. It demonstrated that the inhibition of AR activity could improve the activity of Na+-K+-ATPase and SDJYC had the same effect. Conclusions: SDJYC exerts effects by inhibiting the activity of AR .

Key words: diabetic kidney, Shendan Jianyi Capsule, aldose reductase, Na+ K+ ATPase, sorbinil

CLC Number: 

  • R587.24

Tab 1

Comparison of activity of aldose reductase in kidney of 4 groups (ヌ±S)"

GroupnActivity of aldose reductase
NADPH（0.1 mmol/L）NADH（0.1 mmol/L）
Normal group82.12±0.820.40±0.19
Model group810.20±3.86**3.61±1.56
Sorbinil group83.27±0.88△△1.26±0.27△△
SDJYC group83.23±0.79△△0.96±0.14△△

Tab 2

Comparison of changes of urine protein of 4 groups (ヌ±S, mg/L)"

GroupnUrine protein
4th week8th week
Normal group81 623±1 2151 709±956
Model group82 500±2 310**2 810±2 330**
Sorbinil group82 520±2 4802 360±2 120△△
SDJY group82 570±1 9302 170±1 920△△

Tab 3

Comparison of activity of Na+-K+-ATPase of 4 groups (ヌ±S, mmol Pi·g-1 pro·h-1)"

GroupnActivity of Na+-K+-ATPase
Normal group80.58±0.12
Model group80.36±0.17*
Sorbinil group80.48±0.16△
SDJY group80.47±0.18△
[1] Narayanan S.Aldose reductase and its inhibition in the control of diabetic complications[J].Ann Clin Lab Sci,1993,23(2):148-158
doi: 10.1097/00007691-199304000-00011 pmid: 8457142
[2] Maragoudakis ME, Wasvary J, Hankin H, et al.Human placenta aldose reductase. Forms sensitive and insensitive to inhibition by alrestatin[J].Mol Pharmacol,1984,25(3):425-430
doi: 10.1002/med.2610040405 pmid: 6427599
[3] Lanzetta PA, Alvarez LJ, Reinach PS, et al.An improved assay for nanomole amounts of inorganic phosphate[J].Anal Biochem,1979,100(1):95-97
[4] Cohen MP, Klepser H, Cua E.Effect of diabetes and Sorbinil treatment on phospholipid metabolism in rat glomeruli[J].Biochim Biophys Acta,1986,876(2):226-232
doi: 10.1016/0005-2760(86)90278-X pmid: 3006784
[5] 张家庆, 周云平.部分中药或其成分对大鼠晶体醛糖还原酶的抑制作用[J].中国中药杂志,1989,14(9):557-559
[6] 刘长山, 董砚虎, 逢力男, 等.中药黄芩甙与黄连素对糖尿病鼠醛糖还原酶活性作用的观察[J].中国糖尿病杂志,1996,4(3):163-166
[1] Hong-wei Gu, Zhao-hui Ni, Le-yi Gu, Yu-cheng Yan, Hui-li Dai, Ning-li Li, Min-fang Zhang, Jia-qi Qiang. Effects of Astragalus on expression of renal angiopoietin receptor Tie-2 in diabetic rats. Journal of Chinese Integrative Medicine, 2007, 5(5): 536-540.
[2] Wei Deng, Fang Shu, Jing Chen. Treatment of diabetic nephropathy with integrated traditional Chinese and Western medicine: A report of 30 cases. Journal of Chinese Integrative Medicine, 2005, 3(4): 314-315.
[3] He-xin Cao, Li-qun He, Ya-jing Shen. Changes of SOD, GSH and MDA in renal tissues of diabetic hyperlipidemia rats. Journal of Chinese Integrative Medicine, 2004, 2(1): 36-38.
[4] Yan Huang, Shao-qiang Chen, Geng Zhang, Rui-hua Chen. Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats. Journal of Chinese Integrative Medicine, 2004, 2(1): 39-41.
[5] Li-qun He, He-xin Cao, Ya-jing Shen. Effect and mechanism of Tangshenning Recipe on micro-albuminuria in rats with early diabetic nephropathy. Journal of Chinese Integrative Medicine, 2003, 1(2): 119-121.
[6] Xiao-jing Zhou, Jian-xiong Shen, Lan Huang. Study of the mechanism of preventing proteinuria by Yishen Gujing Decoction (YSGJD) in early diabetic nephropathy. Journal of Chinese Integrative Medicine, 2003, 1(1): 39-41.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3