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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (3): 213-215.doi: 10.3736/jcim20040319

• Original Experimental Research • Previous Articles     Next Articles

Inhibition of Longzhi extracts on tumor growth of transplanted H22 and S180 in mice

Hai-yan Peng1, Yong-hong Zhang1, Meng Wang2, Dong Xia2   

  1. 1. Department of Internal Medicine of Traditional Chinese Medicine, First Clinical College of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China
    2. Institute of Materia Medica of Jiangsu Province, Nanjing, Jiangsu Province 210009, China
  • Online:2004-06-20 Published:2018-10-25

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Objective: To study the inhibitory effect of Longzhi extracts (extracts from a Chinese herbal compound) on the growth of transplanted hepatoma H22 and sarcoma S180 in mice. Methods: Certain dosage of Longzhi extracts was dissolved into distilled water to obtain the suspension of definite concentration. The suspension of 0.2 ml was planted on the right forefoot of each mouse. The mice were randomly divided into groups 24 hours later and treated for 7 days. One day after the treatment stopped, the mice were sacrificed and the tumor masses were taken out and weighed. Results: The inhibition rates of Longzhi extracts on the tumor of transplanted H22 and S180 were 63% and 41% respectively. Conclusion: Longzhi extracts has antitumor action.

Key words: Longzhi extracts, antineoplastic agents, hepatoma, sarcoma 180, mice, laboratory

CLC Number: 

  • R286.91

Tab 1

Effects of Longzhi extracts on tumor growth of transplanted H22 in mice"

Group n Body weight
(beginning/end, g)		 Tumor weight
(g)		 Inhibition rate
(%)
Control 10 21.0/26.0 1.60±0.49
5-FU treated 10 21.0/25.0 0.28±0.16** 82
4 g/kg Longzhi extracts treated 10 20.0/26.5 0.60±0.36** 63
2 g/kg Longzhi extracts treated 10 21.0/27.5 0.84±0.41* 47
1 g/kg Longzhi extracts treated 10 22.0/28.0 0.93±0.58* 42

Tab 2

Effects of Longzhi extracts on tumor growth of transplanted S180 in mice"

Group n Body weight
(beginning/end, g)		 Tumor weight
(g)		 Inhibition rate
(%)
Control 10 21.0/26.0 1.07±0.21
Cytoxan treated 10 21.0/24.5 0.27±0.20** 75
4 g/kg Longzhi extracts treated 10 22.0/27.5 0.63±0.26** 41
2 g/kg Longzhi extracts treated 10 21.0/26.0 0.79±0.24* 26
1 g/kg Longzhi extracts treated 10 20.5/28.0 0.83±0.16* 22
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