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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (3): 213-215.doi: 10.3736/jcim20040319

• Original Experimental Research • Previous Articles     Next Articles

Inhibition of Longzhi extracts on tumor growth of transplanted H22 and S180 in mice

Hai-yan Peng1, Yong-hong Zhang1, Meng Wang2, Dong Xia2   

  1. 1. Department of Internal Medicine of Traditional Chinese Medicine, First Clinical College of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China
    2. Institute of Materia Medica of Jiangsu Province, Nanjing, Jiangsu Province 210009, China
  • Online:2004-06-20 Published:2018-10-25

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Objective: To study the inhibitory effect of Longzhi extracts (extracts from a Chinese herbal compound) on the growth of transplanted hepatoma H22 and sarcoma S180 in mice. Methods: Certain dosage of Longzhi extracts was dissolved into distilled water to obtain the suspension of definite concentration. The suspension of 0.2 ml was planted on the right forefoot of each mouse. The mice were randomly divided into groups 24 hours later and treated for 7 days. One day after the treatment stopped, the mice were sacrificed and the tumor masses were taken out and weighed. Results: The inhibition rates of Longzhi extracts on the tumor of transplanted H22 and S180 were 63% and 41% respectively. Conclusion: Longzhi extracts has antitumor action.

Key words: Longzhi extracts, antineoplastic agents, hepatoma, sarcoma 180, mice, laboratory

CLC Number: 

  • R286.91

Tab 1

Effects of Longzhi extracts on tumor growth of transplanted H22 in mice"

Group n Body weight
(beginning/end, g)		 Tumor weight
(g)		 Inhibition rate
(%)
Control 10 21.0/26.0 1.60±0.49
5-FU treated 10 21.0/25.0 0.28±0.16** 82
4 g/kg Longzhi extracts treated 10 20.0/26.5 0.60±0.36** 63
2 g/kg Longzhi extracts treated 10 21.0/27.5 0.84±0.41* 47
1 g/kg Longzhi extracts treated 10 22.0/28.0 0.93±0.58* 42

Tab 2

Effects of Longzhi extracts on tumor growth of transplanted S180 in mice"

Group n Body weight
(beginning/end, g)		 Tumor weight
(g)		 Inhibition rate
(%)
Control 10 21.0/26.0 1.07±0.21
Cytoxan treated 10 21.0/24.5 0.27±0.20** 75
4 g/kg Longzhi extracts treated 10 22.0/27.5 0.63±0.26** 41
2 g/kg Longzhi extracts treated 10 21.0/26.0 0.79±0.24* 26
1 g/kg Longzhi extracts treated 10 20.5/28.0 0.83±0.16* 22
[1] 叶丽红, 章永红, 吴勉华 , 等. 中医药治疗26例原发性肝癌的疗效观察[J]. 中国临床医药实用杂志, 2003,( 10):49-52
[2] 章永红 . 抗癌中药大全(第1版)[M]. 南京: 江苏科学技术出版社,2000,(第1版): 143, 176-178
[3] 吴孟超 . 中医药在肝癌防治中的作用、地位和存在的问题[J]. 中西医结合学报, 2003,1(3):163-164
Wu MC . Traditional Chinese medicine in prevention and treatment of liver cancer: function, status and existed problems[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(3):163-164
[4] 彭海燕, 章永红, 王瑞平 , 等. 龙芝藻治疗恶性肿瘤的临床研究[J]. 实用中医内科杂志, 2003,17(5):364-365
doi: 10.3969/j.issn.1671-7813.2003.05.017
[5] 沈自尹 . 中医药在调节基因平衡上的优势[J]. 中西医结合学报, 2003,1(1):3-4
Shen ZY . Superiority of traditional Chinese medicine on gene regulation[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(1):3-4
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