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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 470-472.doi: 10.3736/jcim20050613

• Original Clinical Research • Previous Articles     Next Articles

Protective effects of Yanggan Lidan Granules on carbon tetrachloride-induced liver damage in mice

Sheng-fu You1,Pei-yong Zheng1,Guang Ji1,Hua-feng Wei1,Jie Zhao1,Pei-ting Zhu2   

  1. 1. Center of Scientific Research, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    2. Institute of Chinese Traditional Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2005-04-19 Online:2005-11-20 Published:2005-11-20
  • Contact: Pei-Ting ZHU E-mail:crecie@163.com

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Objective

To observe the protective effects of Yanggan Lidan Granules (YGLDG) on carbon tetrachloride (CCl4)-induced liver damage in mice and to find out its mechanism.

Methods

A model of chronic liver damage was established in mice by intraperitoneal injection of CCl4. After three weeks, those model mice were treated with low-, medium-, high-dose YGLDG, Danning Tablets and bifendate respectively for four weeks. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected.

Results

YGLDG could significantly reduce the levels of serum ALT and AST in model mice, and the content of MDA was obviously decreased while the content of SOD was increased in liver tissue.

Conclusion

The therapeutic effect of YGLDG on mice with CCl4-induced liver damage is to relieve the seriousness of liver damage, and its mechanism may relate to reducing peroxidation activity in liver tissue.

Key words: Yanggan Lidan Granules, Carbon tetrachloride, Superoxide dismutase, Malondialdehyde

CLC Number: 

  • R286.5

Tab 1

Serum ALT, AST and SOD, MDA in liver tissues of mice in different groups （$\bar{x}$±s, U/L）"

Group n ALT AST SOD MDA
Normal 9 26.11±6.31 54.00±5.15 163.82±26.37 0.31±0.20
Untreated 9 421.22±90.92** 510.00±92.65** 129.61±24.66* 0.84±0.24**
Low-dose YGLDG-treated 9 240.22±52.97△△ 357.00±104.99△△ 148.03±24.91 0.50±0.23△
Medium-dose YGLDG-treated 9 249.22±51.27△△ 424.89±94.18△ 152.32±29.44△ 0.58±0.18△
High-dose YGLDG-treated 9 246.11±90.09△△ 325.56±87.12△△ 158.67±18.70△△ 0.60±0.17△
DNT-treated 9 370.22±80.57 507.56±77.08 221.06±98.01△ 0.90±0.51
Bifendate-treated 9 31.00±10.26△△ 79.33±20.44△△ 158.21±41.13△△ 0.47±0.10△△
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