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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 473-475.doi: 10.3736/jcim20050614

• Original Clinical Research • Previous Articles     Next Articles

Effects of Sanqi Qiancao Recipe on hemorheological parameters of rabbits with copper intrauterine device

Yu-hua Shen1,Xiang-hua Yin2,Zhao-ling You2,Ling-mei Fu2,Zhao-yang Tan2   

  1. 1. Department of Obstetrics and Gynecology, Third Hospital, Hunan College of Traditional Chinese Medicine, Zhuzhou, Hunan Province 412000, China
    2. Department of Integrated Traditional Chinese and Western Medicine, Hunan College of Traditional Chinese Medicine, Changsha, Hunan Province 410007, China
  • Received:2004-12-20 Online:2005-11-20 Published:2005-11-20
  • Contact: Yu-Hua SHEN


To explore the mechanism of Sanqi Qiancao Recipe (SQR) in treating metrorrhagia caused by copper intrauterine device (IUD) in rabbits and to provide experimental evidence for preventing and treating this disease.


Fifty-six rabbits were randomly divided into seven groups, which were normal control group, sham-operation group, untreated group, indomethacin-treated group, low-dose SQR-treated group, medium-dose SQR-treated group and high-dose SQR-treated group. Copper IUD insertion was operated in rabbits of the last five groups. Rabbits in the last four groups were treated orally with indomethacin and low-, medium- and high-dose SQR respectively for a week. Rabbits in the untreated group, normal control group and sham-operation group were given distilled water orally. Hemotocrit, blood viscosity at low, medium and high shear rate, plasma viscosity and blood sedimentation were examined after treatment.


The hemotocrit, blood viscosity at low, medium and high shear rate and plasma viscosity were higher in the untreated group than those in the normal control group with significant differences (P<0.01) while those indexes in low-, medium- and high-dose SQR-treated groups were significantly lower than those in the untreated group (P<0.05 or P<0.01).


SQR can lead to a decrease in blood viscosity and improve the blood flow, which may be one of the mechanisms of SQR in treating metrorrhagia after copper IUD insertion.

Key words: Intrauterine device, Copper, Metrorrhagia, Sanqi Qiancao Recipe, Hemorheology

CLC Number: 

  • R287.4

Tab 1

Effects of SQR on hemorheological parameters of rabbits with copper IUD ($\bar{x}$±s )"

Group n Hemotocrit (%) Blood viscosity
at low shear
rate (mPa/s)
Blood viscosity at
medium shear
rate (mPa/s)
Blood viscosity at
high shear rate
Plasma viscosity
Normal control 8 35.13±6.08 17.25±4.28 10.60±3.08 3.23±1.08 1.75±0.37
Sham-operation 8 36.38±2.33△△ 17.45±3.79△△ 11.03±1.78△△ 3.45±0.42△△ 1.79±0.29△△
Untreated 8 47.50±7.19** 24.12±6.42** 15.11±2.23** 4.81±1.07** 2.29±0.37**
Indomethacin-treated 8 39.38±5.83△△ 19.40±3.85 12.08±2.48△△ 3.83±0.93 1.91±0.20△△
Low-dose SQR-treated 8 39.63±4.78△△ 18.60±2.77△△ 11.70±1.50△△ 3.58±0.30△△ 1.85±0.26△△
Medium-dose SQR-treated 8 40.75±3.01* 18.62±1.80△△ 11.55±1.59△△ 3.72±0.30△△ 1.86±0.19△△
High-dose SQR-treated 8 40.25±7.27 17.90±3.29△△ 11.06±1.02△△ 3.54±0.39△△ 1.84±0.16△△
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