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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (1): 98-100.doi: 10.3736/jcim20060129

• Literature Review • Previous Articles     Next Articles

Progress in research on antitumor activity of saikosaponin and its mechanism

Yan-li Wang1, Shui-xiang He1, Jin-yan Luo2   

  1. 1. Department of Gastroenterology, First Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province 710061, China
    2. Department of Gastroenterology, Second Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province 710004, China 
  • Online:2006-01-20 Published:2006-01-15

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Key words: Saikosaponin, Antineoplastic drugs (TCD), Mechanisms of action, Review

CLC Number: 

  • R286.91
[1] Kumazawa Y, Kawakita T, Takimoto H , et al. Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice[J]. Int J Immunopharmacol, 1990,12(5):531-537
[2] Ushio Y, Abe H . The effects of saikosaponin on macrophage functions and lymphocyte proliferation[J]. Planta Med, 1991,57(6):511-514
doi: 10.1055/s-2006-960195 pmid: 1818339
[3] Ushio Y, Oda Y, Abe H . Effect of saikosaponin on the immune responses in mice[J]. Int J Immunopharmacol, 1991,13(5):501-508
doi: 10.1016/0192-0561(91)90069-J pmid: 1783462
[4] Kato M, Pu MY, Isobe K , et al. Characterization of the immunoregulatory action of saikosaponin-d[J]. Cell Immunol, 1994,159(1):15-25
doi: 10.1006/cimm.1994.1291 pmid: 7954839
[5] Motoo Y, Sawabu N . Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines[J]. Cancer Lett, 1994,86(1):91-95
doi: 10.1016/0304-3835(94)90184-8 pmid: 7954360
[6] Yano H, Mizoguchi A, Fukuda K , et al. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase[J]. Cancer Res, 1994,54(2):448-454
[7] 宋景贵, 肖正明, 李师鹏 , 等. 柴胡提取物对人肝癌细胞和小鼠S-180肉瘤的抑制作用[J]. 山东中医药大学学报, 2001,25(4):299-301
doi: 10.3969/j.issn.1007-659X.2001.04.032
[8] 陈静波, 夏薇, 崔清潭 . 柴胡皂苷d(SSd) 对HL60细胞增殖的抑制作用[J]. 北京大学学报(自然科学版), 2001,2(6):486-488
[9] 夏薇, 崔新羽, 崔清潭 . 柴胡皂苷d(SSd)对K562细胞增殖的抑制作用[J]. 北京大学学报(自然科学版), 2002,3(2):113-115
doi: 10.3969/j.issn.1009-4822.2002.02.007
[10] Hsu YL, Kuo PL, Chiang LC , et al. Involvement of p53, nuclear factor kappa B and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines[J]. Cancer Lett, 2004,213(2):213-221
[11] Hsu YL, Kuo PL, Lin CC . The proliferative inhibition and apoptotic mechanism of Saikosaponin?D in human non-small cell lung cancer A549 cells[J]. Life Sci, 2004,75(10):1231-1242
[12] Zong Z, Fujikawa-Yamamoto K, Tanino M , et al. Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity[J]. Biochem Biophys Res Commun, 1996,219(2):480-485
[13] Chen JC, Chang NW, Chung JG , et al. Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells[J]. Am J Chin Med, 2003,31(3):363-377
doi: 10.1142/S0192415X03001065 pmid: 12943168
[14] Hsu MJ, Cheng JS, Huang HC . Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes:association with c-myc, p53, and bcl-2 mRNA[J]. Br J Pharmacol, 2000,131(7):1285-1293
[15] 步世忠, 许金廉, 孙继虎 , 等. 柴胡皂苷d上调HL-60细胞糖皮质激素受体mRNA并诱导细胞凋亡[J]. 中华血液学杂志, 1999,20(7):354-356
doi: 10.3760/j:issn:0253-2727.1999.07.005
[16] Chiang LC, Ng LT, Liu LT , et al. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species[J]. Planta Med, 2003,69(8):705-709
doi: 10.1055/s-2003-42797 pmid: 14531019
[17] 张丰华, 黄秀深, 牛朝阳 , 等. 小柴胡汤对S180荷瘤小鼠肿瘤血管生成的影响[J]. 中医药学刊, 2004,22(2):269-270
[18] Bermejo-Benito P, Abad Martinez MJ, Sjlvan Sen AM , et al. In vivo and in vitro antiinflammatory activity of saikosaponins[J]. Life Sci, 1998,63(13):1147-1156
doi: 10.1016/S0024-3205(98)00376-2 pmid: 9763210
[19] Chang WC, Hsu FL . Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds[J]. Prostaglandins Leukot Essent Fatty Acids, 1991,44(1):51-56
[20] Kodama Y, Xiaochuan L, Tsuchiya C , et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells[J]. Planta Med, 2003,69(8):765-767
[21] Kyo R, Nakahata N, Kodama Y , et al. Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells[J]. Biol Pharm Bull, 1999,22(12):1385-1387
[22] 孙明瑜, 谢鸣 . 小柴胡汤诱发的间质性肺炎[J]. 中国中医药信息杂志, 2002,9(7):71-72
doi: 10.3969/j.issn.1005-5304.2002.07.049
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