脾气虚、肝郁脾虚及胃实热证患者阿魏酸药代动力学特征比较

doi:10.3736/jcim20060208

Abstract

Objective

To investigate the nature of syndrome of traditional Chinese medicine by means of pharmacokinetic (PK) method.

Methods

Twenty-one healthy volunteers, 20 patients with syndrome of stagnation of liver qi and spleen deficiency, 22 patients with syndrome of deficiency of spleen qi and 19 patients with syndrome of excess of stomach heat were included and administered to take Jiawei Xiaoyaosan Recipe (JWXYSR). The serum PK parameters of ferulic acid (FA) were examined by high performance liquid chromatography (HPLC) method.

Results

The absorption rate constant (α) and the elimination rate constant (β) were both decreased while the apparent first-order absorption constant (Ka) was enhanced significantly in the patients with syndrome of deficiency of spleen qi; the α, β and K_a were all reduced in the patients with syndrome of stagnation of liver qi and spleen deficiency; the β and Ka were increased in the patients with syndrome of excess of stomach heat, as compared with the corresponding PK parameters in the healthy volunteers (P＜0.01).

Conclusion

The PK analysis of FA in the patients with syndrome of deficiency of spleen qi shows that the absorption rate is accelerated, and both the distribution and elimination rates are slowed down. The absorption, distribution and elimination rates of AF are all slowed down in the patients with syndrome of stagnation of liver-qi and spleen deficiency, while the absorption and elimination rates of AF are both accelerated in the patients with syndrome of excess of stomach heat. There are obvious differences in the PK characteristics among these three syndromes.

Key words: Syndrome of deficiency of spleen qi, Syndrome of stagnation of liver qi and spleen deficiency, Syndrome of excess of stomach heat, Ferulic acid, Pharm

CLC Number:

R285.6

Ping Ren, Xi Huang, Shuang-qing Li, Shu-yun Xu, Mei-hua Wan, Ya-xiong Zhou, Yi-wu Zhou, Wen-fu Tang. Pharmacokinetic characteristics of ferulic acid in patients with different syndromes of deficiency of spleen qi, stagnation of liver qi and spleen deficiency, and excess of stomach heat. Journal of Chinese Integrative Medicine, 2006, 4(2): 147-151.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20060208

http://www.jcimjournal.com/EN/Y2006/V4/I2/147

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References 12

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Time after taking	Serum concentration
JWXYSR (min)	Healthy group (n=21)	DSQ group (n=22)	SLQSD group (n=20)	ESH group (n=19)
5	104.38±23.91	26.77±6.61	10.64±1.48	116.38±58.23
10	140.12±30.33	49.70±7.03	22.81±4.86	130.47±63.59
15	152.94±36.11	62.39±6.91	38.49±5.39	109.34±41.67
30	131.76±27.26	76.95±10.39	52.30±8.93	86.39±24.18
60	100.19±22.87	38.00±9.98	33.76±3.28	53.27±16.36
90	95.73±47.39	27.65±6.50	21.58±3.55	29.12±8.41
120	87.29±18.47	16.57±3.29	18.45±5.17	17.78±3.66

Pharmacokinetics parameter	Value
Pharmacokinetics parameter	Healthy group (n=21)	DSQ group (n=22)	SLQSD group (n=20)	ESH group (n=19)
α (min^–1)	0.093±0.022	0.041±0.014**	0.058±0.021**	0.095±0.610
β (min^–1)	0.005 4±0.003 1	0.002 7±0.001 2**	0.003 1±0.010 2**	0.011 0±0.008 1**
K_a (min^–1)	0.38±0.12	0.82±0.12**	0.19±0.01**	0.71±0.02**
t_1/2α (min)	7.63±1.45	19.48±0.78**	13.54±1.95**	7.95±0.88**
t_1/2Ka (min)	19.40±6.80	29.58±8.76**	3.61±1.77**	0.77±6.96**
K₂₁ (min^–1)	0.037±0.001	0.013±0.023**	0.018±0.030**	0.038±0.052
K₁₀(min^–1)	0.019±0.100	0.009 4±0.001**	0.008 1±0.010**	0.021±0.020
K₁₂ (min^–1)	0.044±0.001	0.022±0.001**	0.032±0.001	0.039±0.001
AUC [(μg·L^–1)·min]	20 201.31±1 900.09	16 741.72±7 000.51**	15 570.11±6 350.60**	19 086.31±7 490.81
t_p (min)	12.35±10.40	26.04±0.72**	37.29 ±14.78**	10.74±20.10
C_max(μg·L^–1)	160.98±6.30	78.25±9.45**	57.47±8.59**	136.73±5.83

Pharmacokinetic characteristics of ferulic acid in patients with different syndromes of deficiency of spleen qi, stagnation of liver qi and spleen deficiency, and excess of stomach heat

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