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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (3): 256-259.doi: 10.3736/jcim20060307

• Original Experimental Research • Previous Articles     Next Articles

Effects of Xuefu Zhuyu Decoction on functions of vascular endothelium in patients with unstable angina pectoris

Bao-xiang Wang1, Xue-mei Dong2, Ai-min Guo1, Jie Zhang1   

  1. 1. Department of Traditional Chinese Medicine, 456th Hospital of People’s Liberation Army, Jinan, Shandong Province 250031, China;
    2.Clinic , Affiliated Hospital of Shandong University of Traditional Chinese Medicine , Jinan , ShandongProvince 250011 , China
  • Online:2006-05-31 Published:2006-05-15

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Objective

To evaluate the effects of Xuefu Zhuyu Decoction (XFZYD) on functions of vascular endothelium in patients with unstable angina pectoris (UAP). 

Methods

Fifty patients with UAP were randomly divided into two groups: XFZYD-treated group with 32 cases and control group with 18 cases. The patients in the control group were given regular therapy, while the patients in the XFZYD-treated group were given XFZYD additionally on the basis of regular therapy. All patients in both groups were treated for 8 weeks. Then the contents of serum endothelin (ET), nitric oxide (NO), soluble vascular cell adhesive molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were examined by radioimmunoassay, enzymic method and enzyme-linked immunosorbent assay (ELISA) respectively. 

Results

The total response rate in the XFZYD-treated group was 93.75%, which was significantly higher than 66.67% in the control group (P＜0.05). The contents of serum ET, sVCAM-1 and sICAM-1 in the XFZYD-treated group were much lower than those in the control group (P＜0.01), while the content of serum NO was obviously higher than that in the control group (P＜0.01). 

Conclusion

XFZYD can improve the functions of vascular endothelium by lowering the levels of endothelium-derived contracting substances, enhancing the levels of endothelium-derived relaxing substances, and reducing the cell adhesions, and hence to raise the therapeutic effects on UAP.

Key words: Xuefu Zhuyu Decoction, Angina, Unstable, Pectoris, Endothelium, Vascular, Endothelin, Nitric oxide, Soluble vascular cell adhesion molecule-1, Soluble

CLC Number: 

  • R256.22

Table 1

Contents of serum ET, NO, sVCAM-1 and sICAM-1 before and after treatment in two groups（ヌ±S ）"

GroupnET (ng/L)NO (μmol/L)sVCAM-1 (μg/L)sICAM-1 (μg/L)
XFZYD-treated
Before treatment32127.4±9.545.1±9.1460.1±40.8317.6±38.8
After treatment3278.5±12.5**△△67.7±11.3**△△421.3±39.1**△△270.9±40.3**△△
Control group
Before treatment18121.1±12.345.5±9.7461.3±34.7316.2±50.3
After treatment18113.3±11.8**52.6±8.9**438.3±39.9326.7±39.1
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