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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (6): 518-521.doi: 10.3736/jcim20090605

• Original Clinical Research • Previous Articles     Next Articles

Color Doppler ultrasound evaluation of a Chinese herbal formula in treating lower limb arteriosclerosis: A randomized controlled trial

Xian-jun Tonga,Xiao-yu Xianga,Zun-hua Chenga,Li Chena,Xian-chuan Chenb,Jing-xian Chenb   

  1. a Department of Ultrasound, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    b Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2009-03-13 Accepted:2009-04-16 Online:2009-06-20 Published:2009-06-15

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Objective

To observe the effects of a Chinese compound herbal medicine for reinforcing qi, activating blood circulation, expelling phlegm and dredging collaterals in treatment of lower limb arteriosclerosis.
Methods

The outpatients and inpatients with lower limb arteriosclerosis from Shanghai Yueyang Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into control group and treatment group after color Doppler ultrasound inspection, and there were 30 cases in each group. The patients in the treatment group were treated with simvastatin and a Chinese compound herbal medicine for reinforcing qi, activating blood circulation, expelling phlegm and dredging collaterals, and the patients in the control group were treated only with simvastatin. The color Doppler ultrasound imaging of lower limb arteries including inside diameter, intima-media thickness, and plaque area in all the patients were examined after 6-month treatment. The levels of serum total cholesterol (TC) and low-density lipoprotein (LDL) were detected too.
Results

After the treatment, the lower limb artery intima-media thickness and artery plaque area in the treatment group decreased obviously as compared with those in the control group (P<0.05). Color Doppler flow imaging showed that the percentage of patients with uniphase wave decreased from 26.67% (8/30) to 6.67% (2/30) in the treatment group (P<0.05), and from 26.67% (8/30) to 16.67% (5/30) in the control group (P<0.05) as compared with those before the treatment, and there was also a significant difference between the two groups (P<0.05). The concentrations of serum TC and LDL in the treatment group were lower than those in the control group (P<0.05).
Conclusion

Color Doppler ultrasound showed that the Chinese compound medicine for reinforcing qi, activating blood circulation, expelling phlegm and dredging collaterals has positive effects on lower limb arteriosclerosis.

Key words: Arteriosclerosis, Lower extremity, Doppler ultrasound, Traditional Chinese herbal drugs, Reinforcing qi, Activating blood circulation, Expelling phlegm, Dredging collaterals, Randomized controlled trial

Table 1

Inside diameter, intima-media thickness and artery plaque area of femoral and popliteal arteries in two groups（x±s）"

Group n Femoral artery Popliteal artery
Inside diameter
(mm)		 Intima-media
thickness (mm)		 Plaque area
(mm2)		 Inside
diameter (mm)		 Intima-media
thickness (mm)		 Plaque
area (mm2)
Control
Before treatment 30 6.91±1.31 0.97±0.21 10.75±4.22 5.38±0.92 0.95±0.22 2.69±0.87
After treatment 30 6.87±0.99 0.92±0.17 7.55±3.85 5.37±0.77 0.85±0.18 2.68±0.71
Treatment
Before treatment 30 6.91±1.16 0.93±0.14 11.20±4.18 4.94±0.71 0.91±0.17 2.14±0.89
After treatment 30 6.94±1.16 0.85±0.14*△ 7.25±3.80*△ 4.95±0.76 0.79±0.12*△ 1.56±0.60*△
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