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Journal of Integrative Medicine ›› 2014, Vol. 12 ›› Issue (2): 67-75.doi: 10.1016/S2095-4964(14)60019-4

Special Issue: Traditional Chinese Medicine

• Review •     Next Articles

The roles of traditional Chinese medicine in gene therapy

Chang-quan Linga,b, Li-na Wanga, Yuan Wanga,b, Yuan-hui Zhanga,b, Zi-fei Yina, Meng Wanga,b, Chen Lingc,d   

  1. Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China
    Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32611, USA
     Powell Gene Therapy Center, University of Powell Gene Therapy Center, University of Florida College of Medicine, Gainesville, Florida 32611, USA
  • Received:2014-02-26 Accepted:2014-03-07 Online:2014-03-10 Published:2014-03-15

The field of gene therapy has been increasingly studied in the last four decades, and its clinical application has become a reality in the last 15 years. Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM is well-known for its various roles in preventing and treating infectious and chronic diseases, and its usage in other modern clinical practice. However, whether TCM can be applied alongside gene therapy is a topic that has not been systematically examined. Here we provide an overview of TCM theories in relation to gene therapy. We believe that TCM theories are congruent with some principles of gene therapy. TCM-derived drugs may also act as gene therapy vehicles, therapeutic genes, synergistic therapeutic treatments, and as co-administrated drugs to reduce side effects. We also discuss in this review some possible approaches to combine TCM and gene therapy.

Key words: Gene therapy, Medicine, Chinese traditional, Reviews

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