Health-promoting and disease-preventive potential of Trianthema portulacastrum Linn. (Gadabani)—An Indian medicinal and dietary plant

doi:10.1016/S2095-4964(16)60247-9

Abstract

It is estimated that 80% of the world population depends on traditional medicine for primary healthcare need. Trianthema portulacastrum Linn. (family: Aizoaceae) is a small perennial weed found in the Americas, Africa, India, and other regions of the world. This plant is used extensively in Indian traditional medicines and is also consumed as a vegetable throughout Asia for its perceived health benefits. Phytochemical analysis of T. portulacastrum reveals the presence of alkaloids, flavonoids, terpenoids, saponins, and phenolic compounds. Emerging studies demonstrate that crude extracts as well as bioactive phytoconstituents of T. portulacastrum exhibit potent antioxidant, anti-infective, analgesic, and anti-inflammatory activities. A growing number of in vitro and in vivo studies demonstrate various biological and pharmacological activities, including prevention and amelioration of hepatotoxicity, nephrotoxicity, hyperglycemia, hyperlipidemia, infectious diseases and cancer. This review aims to present and analyze available literature to understand the full potential of T. portulacastrum in health promotion and disease prevention. Current limitations and future directions of research on this medicinal and dietary plant are also critically discussed.

Key words: Trianthema portulacastrum, Phytochemistry, Pharmacology, Health benefits, Review, Herbal medicine

Jason Yamaki, Kalyan C. Nagulapalli Venkata, Animesh Mandal, Piyali Bhattacharyya, Anupam Bishayee. Health-promoting and disease-preventive potential of Trianthema portulacastrum Linn. (Gadabani)—An Indian medicinal and dietary plant. Journal of Integrative Medicine, 2016, 14(2): 84-99.

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References

1 Harvey AL. Natural products in drug discovery. Drug Discov Today. 2008; 13(19-20): 894-901.
2 utler MS. Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep. 2008; 25(3): 475-516.
3 Maurya R, Srivastava S, Kulshreshta DK, Gupta CM. Traditional remedies for fertility regulation. Curr Med Chem. 2004; 11(11): 1431-1450.
4 Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP.Indian herbs and herbal drugs used for the treatment of diabetes.J Clin Biochem Nutr. 2007; 40(3): 163-173.
5 Seth SD, Sharma B.Medicinal plants of India.Indian J Med Res. 2004; 120(1): 9-11.
6 Prasad S.Pharmacognostical studies of Punarnava; stem and leaf characteristics of Boerhaavia diffusa Linn. and Trianthema Portulacastrum Linn.J Am Pharm Assoc Am Pharm Assoc. 1948; 37(3): 103-115.
7 Jansen PCM. 2004. Trianthema portulacastrum L. [Internet] Record from PROTA4U. Grubben GJH, Denton OA. PROTA (Plant Resources of Tropical Africa/Ressources végétales de l’Afrique tropicale). Wageningen, Netherlands. . 2004. Trianthema portulacastrum L. [Internet] Record from PROTA4U. Grubben GJH, Denton OA. PROTA (Plant Resources of Tropical Africa/Ressources végétales de l’Afrique tropicale). Wageningen, Netherlands. http://www.prota4u.org/search.asp.
8 Medicinal plants of Bangladesh: Trianthema portulacastrum L. [2015-04-07]. . [2015-04-07]. http://www.mpbd.info/plants/trianthema-portulacastrum.php.
9 Al Sherif EA, Gharieb HR.Allelochemical effect ofTrianthema portulacastrum L. on Amaranthus viridis L. supports the ecological importance of allelopathy. Afr J Agric Res. 2011; 6(32): 6690-6697.
10 Shivhare MK, Singour PK, Chaurasiya PK, Pawar RS.Trianthema portulacastrum Linn.(Bishkhapra).Pharmacogn Rev. 2012; 6(12): 132-140.
11 Pare S, Dabhadkar D.Evaluation of potential antifertility activity of plant Trianthema portulacastrum in female albino rat. Int J Appl Pharm Sci Biomed Sci.2013; 2(1): 7-11.
12 Ahmad J, Farooqui AH, Ahmad S.Trianthema portulacastrum L., an herbal drug for the cure of edema. J Herbs Spices Med Plants. 2000; 7(2): 65-70.
13 Shafat Karim M, Kalam MA, Anzar Alam M, Alam K, Jahan N, Jafri MA.Biskhapra (Trianthema portulacastrum Linn) and its medicinal utility mentioned in Unani system of medicine—A review. Int J Pharma Sci Res.2015; 6(4): 790-795.
14 Ara A, Akram A, Ajmal M, Akhund S, Nayyar BG.Pharmacological, nutritional and allelopathic attributes of noxious weed,Trianthema portulacastrum L.(Horsepurslane). Pure Appl Biol. 2015; 4(3): 340-352.
15 Prescott-Allen R, Prescott-Allen C.How many plants feed the world?Conserv Biol. 1990; 4(4): 365-374.
16 Khan N, Sultana A, Tahir N, Jamila N.Nutritional composition, vitamins, minerals and toxic heavy metals analysis ofTrianthema portulacastrum L., a wild edible plant from Pakistan. Afr J Biotech. 2013; 12(42): 6079-6085.
17 Hussain J, Rehman NU, Khan AL, Hamayun M, Hussain SM, Shinwari ZK.Proximate and essential nutrients evaluation of selected vegetables species from Kohat region, Pakistan. Pak J Botany.2010; 42(4): 2847-2855.
18 Bharathidhasan S Jr, Ganesh Babu NS, Balakrishnan V.In vitro evaluation of the nutritive value of Trianthema portulacastrum as a source of fodder for ruminants. Malays J Nutr. 2007; 13(2): 179-187.
19 Khare C.Indian medicinal plants, an illustrated dictionary. New York: Springer-Verlag. 2007.
20 Nawaz HR, Malik A, Ali MS.Trianthenol: an antifungal tetraterpenoid fromTrianthema portulacastrum(Aizoaceae). Phytochemistry. 2001; 56(1): 99-102.
21 Asif M, Atif M, Malik ASA, Dan ZC, Ahmad I, Ahmad A.Diuretic activity of Trianthema portulacastrum crude extract in Albino rats. Trop J Pharm Res.2013; 12(6): 967-972.
22 Kavitha D, Parvatham R, Padma PR.Assessment of Trianthema portulacastrum for its antimicrobial potential and investigation of their phytochemicals using HPTLC, GC-MS, and IR. Int J Pharm Pharm Sci.2013; 6(1): 675-686.
23 Kokpol U, Wannachet-Isara N, Tip-Pyang S, Chavasiri W, Veerachato G, Simpson J, Weavers RT.A C-methylflavone fromTrianthema portulacastrum. Phytochemistry. 1997; 44(4): 719-722.
24 Banerji A, Chintawar GJ, Joshi NK, Chadha MS.Isolation of ecdysterone from Indian plants.Phytochemistry. 1971; 10(9): 2225-2226.
25 Chopra RN, Chatterjee CN, Ghosh S.A comparative study ofBoerhaavia diffusa Linn, and the white and red flowered varieties of Trianthema portulacastrum Linn. J Med Res. 1940; 28(2): 475-480.
26 Shyam Sunder A, Rajalakshmi G, Bharath A, Rajeshwar Y.Antihyperglycemic activity ofTrianthema portulacastrum plant in streptozotocin induced diabetic rats. Pharmacologyonline. 2009; 1: 1006-1011.
27 Liou GY, Storz P.Reactive oxygen species in cancer. Free Radic Res.2010; 44(5): 479-496.
28 Anchuri SS, Rama Narasimha Reddy A, Krishna Prasad D, Poorna Chander K, Vemula S. Free radical scavenging activity of methanolic whole plant extract ofTrianthema portulacastrum Linn (Aizoaceae). Int J Pharm Sci. 2010; 2(2): 589-592.
29 Yaqoob S, Sultana B, Mushtaq M.In vitro antioxidant activities of Trianthema portulacastrum L. hydrolysates. Prev Nutr Food Sci. 2014; 19(1): 27-33.
30 Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H.Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.J Clin Invest. 2003; 112(12): 1821-1830.
31 Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N.Low grade chronic inflammation in women with polycystic ovarian syndrome.J Clin Endocrinol Metab. 2001; 86(6): 2453-2455.
32 Ostrand-Rosenberg S, Sinha P.Myeloid-derived suppressor cells: linking inflammation and cancer.J Immunol. 2009; 182(8): 4499-4506.
33 Bishayee A.The role of inflammation and liver cancer. Adv Exp Med Biol.2014; 816: 401-435.
34 Vohora SB, Shah SA, Naqvi SA, Ahmad S, Khan MS.Studies on Trianthema portulacastrum. Planta Med. 1983; 47(2): 106-108.
35 Kendri SS, Wari UG.Screening of the anti-inflammatory activity of “Trianthema portulacastrum” in acute models of inflammation. J Evol Med Dental Sci.2015; 4(30): 5185-5189.
36 Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J.Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis.2009; 48(1): 1-12.
37 Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J Jr; Infectious Diseases Society of America. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America.Clin Infect Dis. 2008; 46(2): 155-164.
38 Hussain A, Khan MN, Iqbal Z, Sajid MS, Khan MK.Anthelmintic activity of Trianthema portulacastrum L. and Musa paradisiaca L.against gastrointestinal nematodes of sheep. Vet Parasitol. 2011; 179(1-3): 92-99.
39 Shanmugam SK, Bama S, Kiruthiga N, Kumar RS, Sivakumar T, Dhanabal P.Investigation of analgesic activity of leaves part of theTrianthema portulacastrum(L) in standard experimental animal models. Int J Green Pharm. 2007; 1(1): 39-41.
40 Laupland KB.Fever in the critically ill medical patient.Crit Care Med. 2009; 37(Suppl 7): S273-S278.
41 Hübschle T, Mütze J, Mühlradt PF, Korte S, Gerstberger R, Roth J.Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL- 1. Am J Physiol Regul Integr Comp Physiol.2006; 290(1): R180-R187.
42 Fabricant DS, Farnsworth NR.The value of plants used in traditional medicine for drug discovery. Environ Health Perspect.2001; 109(Suppl 1): 69-75.
43 Andrade-Cetto A, Heinrich M.Mexican plants with hypoglycaemic effect used in the treatment of diabetes.J Ethnopharmacol. 2005; 99(3): 325-348.
44 Anreddy RNR, Porika M, Yellu NR, Devarakonda RK.Hypoglycemic and hypolipidemic activities ofTrianthema portulacastrum Linn. plant in normal and alloxan induced diabetic rats. Int J Pharmacol. 2010; 6(2): 129-133.
45 Dinan L.Phytoecdysteroids: biological aspects.Phytochemistry. 2001; 57(3): 325-339.
46 Ravishankar GA, Mehta AR.Control of ecdysterone biogenesis in tissue culture ofTrianthema portulacastrum. J Nat Prod. 1979; 42(2): 152-158.
47 Wilborn CD, Taylor LW, Campbell BI, Kerksick C, Rasmussen CJ, Greenwood M, Kreider RB.Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males.J Int Soc Sports Nutr. 2006; 3: 19-27.
48 Kelly BB, Narula J, Fuster V.Recognizing global burden of cardiovascular disease and related chronic diseases.Mt Sinai J Med. 2012; 79(6): 632-640.
49 Bui Q.Cochrane for clinicians. First-line treatment for hypertension.Am Fam Physician. 2010; 81(11): 1333-1335.
50 Karim MS, Kalam MA, Jahan N, Ahmad G, Jafri MA.Evaluation of diuretic activity of hydro alcoholic extract ofBiskhapra leaves(Trianthema portulacastrum Linn) in rat. Hippocratic J Unani Med. 2011; 6(3): 81-88.
51 Sree Lakshmi K, Prabhakaran V, Mallikarjuna G, Gowthami A.Antilithiatic activity of Trianthema portulacastrum L. and Gymnema sylvestre R.Br against ethylene glycol induced urolithiasis. Int J Pharm Sci Rev Res. 2014; 25(1): 16-22.
52 Yuliana ND, Khatib A, Link-Struensee AM, Ijzerman AP, Rungkat-Zakaria F, Choi YH, Verpoorte R.Adenosine A1 receptor binding activity of methoxy flavonoids fromOrthosiphon stamineus. Planta Med. 2009; 75(2): 132-136.
53 Dearing MD, Mangione AM, Karasov WH.Plant secondary compounds as diuretics: an overlooked consequence.Am Zool. 2001; 41(4): 890-901.
54 Bishayee A, Mandal A, Chatterjee M.Prevention of alcohol-carbon tetrachloride-induced signs of early hepatotoxicity in mice byTrianthema portulacastrum L. Phytomedicine. 1996; 3(2): 155-161.
55 Mandal A, Bishayee A, Chatterjee M.Trianthema portulacastrum affords antihepatotoxic activity against carbon tetrachloride-induced chronic liver damage in mice: reflection in subcellular levels. Phytother Res. 1997; 11(3): 216-221.
56 Mandal A, Bandyopadhyay S, Chatterjee M.Trianthema portulacastrum L. reverses hepatic lipid peroxidation, glutathione status and activities of related antioxidant enzymes in carbon tetrachloride-induced chronic liver damage in mice. Phytomedicine. 1997; 4(3): 239-244.
57 Mandal A, Karmakar R, Bandyopadhyay S, Chatterjee M.Antihepatotoxic potential of Trianthema portulacastrum in carbon tetrachloride-induced chronic hepatocellular injury in mice: reflection in haematological, histological and biochemical characteristics. Arch Pharm Res.1998; 21(3): 223-230.
58 Sarkar A, Pradhan S, Mukhopadhyay I, Bose SK, Roy S, Chatterjee M.Inhibition of early DNA-damage and chromosomal aberrations byTrianthema portulacastrum L. in carbon tetrachloride-induced mouse liver damage. Cell Biol Int. 1999; 23(10): 703-708.
59 Kumar G, Banu GS, Pappa PV, Sundararajan M, Pandian MR.Hepatoprotective activity ofTrianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats. J Ethnopharmacol. 2004; 92(1): 37-40.
60 Kumar G, Banu GS, Pandian MR.Evaluation of the antioxidant activity ofTrianthema portulacastrum L. Indian J Pharmacol. 2005; 37(5): 331-333.
61 Sharmila Banu G, Kumar G, Murugesan AG.Ethanolic leaves extract ofTrianthema portulacastrum L. ameliorates aflatoxin B1 induced hepatic damage in rats. Indian J Clin Biochem. 2009; 24(3): 250-256.
62 Sharmila Banu G, Kumar G, Murugesan AG.Effect of ethanolic leaf extract ofTrianthema portulacastrum L. on aflatoxin induced hepatic damage in rats. Indian J Clin Biochem. 2009; 24(4): 414-418.
63 Shyam Sunder A, Ramma Narsimha Reddy A, Rajeshwar Y, Kiran G, Krishna Prasad D, Baburao B, Thirumurugu S, Karthik A. Protective effect of methanolic extract ofTrianthema portulacastrum in atherosclerotic diet induced renal and hepatic changes in rats. Der Pharmacia Lett. 2010; 2(1): 540-545.
64 Balamurugan G, Jagan Mohan CM, Muthusamy P.Protective effect ofTrianthema portulacastrum Linn leaves on gentamicin induced nephrotoxicity in rats. J Nat Remedies. 2009; 9(2): 165-169.
65 Karim SM, Asraf N, Kalam A, Jahan N, Jafri MA, Ahmad G.Effects ofBiskhapra (Trianthema portulacastrum Linn.) leaves extract in adriamycin induced nephrotic syndrome. Int J Green Pharm. 2011; 5(4): 329-335.
66 Bhattacharya S, Chatterjee M.Protective role ofTrianthema portulacastrum against diethylnitrosoamine-induced experimental hepatocarcinogenesis. Cancer Lett. 1998; 129(1): 7-13.
67 Bhattacharya S, Chatterjee M.Trianthema portulacastrum restores the antioxidant defense enzyme levels and hepatic biotransformation patterns in experimental rat hepatocarcinogenesis. Ital J Biochem. 1998; 47(4): 225-232.
68 Bhattacharya S, Chatterjee M.Inhibitory effect ofTrianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis. Neoplasma. 1999; 46(2): 105-111.
69 Bishayee A, Mandal A.Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats. Mut Res. 2014; 768: 107-118.
70 Mandal A, Bishayee A.Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-κB and Nrf2 signaling pathways. Int [J] Mol Sci. 2015; 16(2): 2426-2445.

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