Search JIM Advanced Search

Journal of Integrative Medicine ›› 2016, Vol. 14 ›› Issue (5): 322-335.doi: 10.1016/S2095-4964(16)60270-4

• Review • Previous Articles     Next Articles

Post-hematopoietic stem cell transplantation in patients with hematologic disorders: Chinese herbal medicine for an unmet need

Tom Fleischera, Tung-Ti Changb,c,d, Hung-Rong Yenb,c,e,f   

  1. a Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University,Taichung 40402, Taiwan, China
    b Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan 40447, China
    c School of Chinese Medicine, China Medical University, Taichung, Taiwan 40402, China
    d School of Post-baccalaureate Chinese Medicine, China Medical University, Taichung 40402, Taiwan,China 
    e Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 40402,Taiwan, China 
    f Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan, China
  • Received:2016-05-02 Accepted:2016-07-04 Online:2016-09-15 Published:2016-09-15
  • Contact: Hung-Rong Yen, MD, PhD; E-mail:

While much progress has been made in the field of hematopoietic stem cell transplantation (HSCT), headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine (CHM) for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention. Of the 9 papers, 6 were published by the same group of researchers. The focus of the reviewed studies was heterogeneous, and the objectives varied widely. With the exception of one randomized control trial, all of the studies were retrospective and observational; the median number of patients was 11.5, with the largest study containing 104 patients. CHM treatment was largely divided into two stages: (1) pre-HSCT, which was initiated as soon as conditioning chemotherapy was administered and aimed to counterbalance the adverse effects of these potent agents; (2) post-HSCT, which began immediately after transplantation and was intended to promote engraftment, control graft-versus-host disease and prolong survival. In addition, the 9 Chinese materia medica most commonly prescribed (appearing in four studies) were: Shengdihuang (Rehmannia glutinosa), Baizhu (Atractylodes macrocephala), Renshen (Panax ginseng), Dangshen (Codonopsis pilosula), Maimendong (Ophiopogon japonicus), Danggui (Angelica sinensis), Taizishen (Pseudostellaria heterophylla), Huangqi (Astragalus membranaceus) and Ejiao (Equus asinus).

Key words: Hematologic diseases, Hematologic disorder, Hematopoietic stem cells, Chinese herbal medicine, Hematopoietic stem cell transplantation, Review

1 Leung AY, Tse E, Hwang YY, Chan TS, Gill H, Chim CS,Lie AKW, Kwong YL.Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor.Am J Hematol. 2013; 88(6): 485-491.
2 Duval M, Klein JP, He W, Cahn JY, Cairo M, Camitta BM, Kamble R, Copelan E, de Lima M, Gupta V, Keating A, Lazarus HM, Litzow MR, Marks DI, Maziarz RT, Rizzieri DA, Schiller G, Schultz KR, Tallman MS, Weisdorf D. Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure.J Clin Oncol. 2010; 28(23): 3730-3738.
3 Gratwohl A, Brand R, Frassoni F, Rocha V, Niederwieser D, Reusser P, Einsele H, Cordonnier C; Acute and Chronic Leukemia Working Parties; Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time.Bone Marrow Transplant. 2005; 36(9): 757-769.
4 Apperley J, Carreras E, Gluckman E, Masszi T.The ESH-EBMT handbook on haemoatpoietic stem cell transplantation. 6th ed. European School of Haematology, European Society for Blood and Marrow Transplantation. 2012.
5 Flowers ME, Inamoto Y, Carpenter PA, Lee SJ, Kiem HP, Petersdorf EW, Pereira SE, Nash RA, Mielcarek M, Fero ML, Warren EH, Sanders JE, Storb RF, Appelbaum FR, Storer BE, Martin PJ.Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood.2011; 117(11): 3214-3219.
6 Seggewiss R, Einsele H.Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update. Blood.2010; 115(19): 3861-3868.
7 Toubert A, Glauzy S, Douay C, Clave E.Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again. Tissue Antigens.2012; 79(2): 83-89.
8 Walter RB, Buckley SA, Pagel JM, Wood BL, Storer BE, Sandmaier BM, Fang M, Gyurkocza B, Delaney C, Radich JP, Estey EH, Appelbaum FR.Significance of minimal residual disease before myeloablative allogeneic hematopoietic cell transplantation for AML in first and second complete remission. Blood.2013; 122(10): 1813-1821.
9 Tzannou I, Leen AM.Accelerating immune reconstitution after hematopoietic stem cell transplantation. Clin Trans Immunol.2014; 3(2): e11.
10 Airoldi I, Bertaina A, Prigione I, Zorzoli A, Pagliara D, Cocco C, Meazza R, Loiacono F, Lucarelli B, Bernardo ME, Barbarito G, Pende D, Moretta A, Pistoia V, Moretta L, Locatelli F.γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes. Blood.2015; 125(15): 2349-2358.
11 Di Ianni M, Falzetti F, Carotti A, Terenzi A, Castellino F, Bonifacio E, Del Papa B, Zei T, Ostini RI, Cecchini D, Aloisi T, Perruccio K, Ruggeri L, Balucani C, Pierini A, Sportoletti P, Aristei C, Falini B, Reisner Y, Velardi A, Aversa F, Martelli MF.Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood.2011; 117(14): 3921-3928.
12 Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, Defor T, Levine BL, June CH, Rubinstein P, McGlave PB, Blazar BR, Wagner JE. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.Blood. 2011; 117(3): 1061-1070.
13 Fry TJ, Mackall CL.Interleukin-7: from bench to clinic. Blood.2002; 99(11): 3892-3904.
14 Biganzoli L, Untch M, Skacel T, Pico JL.Neulasta (pegfilgrastim): a once-per-cycle option for the management of chemotherapy-induced neutropenia. Semin Oncol.2004; 31(3 Suppl 8): 27-34.
15 Chen D, Zuo G, Li C, Hu X, Guan T, Jiang R, Li J, Lin X, Li F, Luo C, Wang H, Lei C, Long X, Wang Y, Wang J.Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway. J Ethnopharmacol.2009; 126(2): 215-220.
16 Fang GL, Gao RL, Lin XJ, Jin JM.Effects of Ginseng panaxadiol saponin on proliferation and differentiation of human bone marrow CD34+ cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi.2007; 15(4): 776-779. Chinese with abstract in English.
17 Gao RL, Chen XH, Lin XJ, Qian XD, Xu WH, Chong BH.Effects of notoginosides on proliferation and upregulation of GR nuclear transcription factor in hematopoietic cells. Acta Pharmacol Sin.2007; 28(5): 703-711.
18 Jin J, Tao H, Gao R.Effect of ginsenosides on proliferation and differentiation of human CD34+ hematopoietic stem/ progenitor cells. Zhongguo Zhong Xi Yi Jie He Za Zhi.2000; 20(9): 673-676. Chinese with abstract in English.
19 Kim SG, Lee AJ, Bae SH, Kim SM, Lee JH, Kim MJ, Jang HB.Total extract of Korean red ginseng facilitates human bone marrow hematopoietic colony formation in vitro. Blood Res.2014; 49(3): 177-181.
20 Liu M, Tan H, Zhang X, Liu Z, Cheng Y, Wang D, Wang F.Hematopoietic effects and mechanisms of Fufang Ejiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice. J Ethnopharmacol.2014; 152(3): 575-584.
21 Niu YP, Qian XD, Wang WX.Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells. Zhongguo Zhong Xi Yi Jie He Za Zhi.2004; 24(2): 127-129, 132. Chinese with abstract in English.
22 Qian XD, Gao RL, Ma K, Jin JM. Proliferation and differentiation of human CD34+ hematopoietic stem/ progenitor cells induced by Panax notoginosides. Zhongguo Shi Yan Xue Ye Xue Za Zhi.2003; 11(2): 120-123. Chinese with abstract in English.
23 Sun X, Gao RL, Lin XJ, Xu WH, Chen XH.Panax notoginseng s aponin s induced u p - r egulat i o n , phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells. Chin J Integr Med. 2013; 19(2): 112-118.
24 Wang JW, Wang YP, Wang SL, Jiang R.Synergistic effects of total saponins of Panax ginseng in combination with hematopoietic growth factor on proliferation and differentiation of CD34+ cells ex vivo. Zhongguo Shi Yan Xue Ye Xue Za Zhi.2006; 14(5): 959-963. Chinese with abstract in English.
25 Wang SL, Chen D, Wang YP, Liu YG, Jiang R.Modulation of expression of human GM-CSF and GM-CSFRα by total saponins of Panax ginseng. Sheng Li Xue Bao.2003; 55(4): 487-492. Chinese with abstract in English.
26 Wei JA, Cheng ZA, Wen JX.Comparative study of enhancing effect on mRNA expression of hematopoietic growth factors in rat bone marrow mesenchymal stem cells by ginseng polysaccharide and ginsenoside. Zhongguo Zhong Xi Yi Jie He Za Zhi.2011; 31(3): 372-375. Chinese with abstract in English.
27 Yang BH, Zhu LQ, Zhang JZ, Niu FL, Cui W. Effects of Astragalus membranaceus and Panax notoginseng on the transformation of bone marrow stem cells and proliferation of EPC in vitro. Zhongguo Zhong Yao Za Zhi. 2005; 30(22):1761-1763. Chinese with abstract in English.
28 Zuo G, Guan T, Chen D, Li C, Jiang R, Luo C, Hu X, Wang Y, Wang J.Total saponins of Panax ginseng induces K562 cell differentiation by promoting internalization of the erythropoietin receptor. Am J Chin Med. 2009; 37(4): 747-757.
29 Shen B, Chen L, Zhou K, Jin KK.Effects of astragalus and angelica on bone marrow stem cells proliferation and VEGF protein expression in vitro. Zhongguo Gu Shang.2011; 24(8): 652-655. Chinese with abstract in English.
30 Liang QD, Lu XQ, Ma ZC, Tan HL, Ma BP, Gao Y, Wang SQ.Preliminary study on hematopoietic constituents of si-wu-tang. Zhongguo Zhong Yao Za Zhi.2004; 29(6): 546- 549. Chinese with abstract in English.
31 Yuan Y, Hou S, Lian T, Han Y.Studies of Rehmannia glutinosa Libosch. f.hueichingensis as a blood tonic. Zhongguo Zhong Yao Za Zhi. 1992; 17(6): 366-368, inside backcover. Chinese with abstract in English.
32 Hua Z, Song S, Luo C, Wang J, Wang Y. Effect of angelica polysaccharides co-erythropoietin on JAK2/STAT5 signal transduction pathway in hematopoietic stem/progenitor cells. Zhongguo Zhong Yao Za Zhi. 2009; 34(24):3268- 3271. Chinese with abstract in English.
33 Lee JG, Hsieh WT, Chen SU, Chiang BH.Hematopoietic and myeloprotective activities of an acidic Angelica sinensis polysaccharide on human CD34+ stem cells. J Ethnopharmacol.2012; 139(3): 739-745.
34 Liu C, Li J, Meng FY, Liang SX, Deng R, Li CK, Pong NH, Lau CP, Cheng SW, Ye JY, Chen JL, Yang ST, Yan H, Chen S, Chong BH, Yang M.Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway. BMC Complement Altern Med. 2010; 10: 79.
35 Mei QB, Tao JY, Cui B.Advances in the pharmacological studies of radixAngelica sinensis (Oliv) Diels (Chinese Danggui). Chin Med J (Engl). 1991; 104(9): 776-781.
36 Mei QB, Tao JY, Zhang HD, Duan ZX, Chen YZ.Effects of Angelica sinensis polysaccharides on hemopoietic stem cells in irradiated mice. Zhongguo Yao Li Xue Bao.1988; 9(3): 279-282. Chinese with abstract in English.
37 Wang Y, Zhu B.The effect of angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell. Zhonghua Yi Xue Za Zhi.1996; 76(5): 363-366. Chinese with abstract in English.
38 Bae J, Koo J, Kim S, Park TY, Kim MY.Ginsenoside Rp1 exerts anti-inflammatory effects via activation of dendritic cells and regulatory T cells. J Ginseng Res.2012; 36(4): 375-382.
39 Jhun J, Lee J, Byun JK, Kim EK, Woo JW, Lee JH, Kwok SK, Ju JH, Park KS, Kim HY, Park SH, Cho ML.Red ginseng extract ameliorates autoimmune arthritis via regulation of STAT3 pathway, Th17/Treg balance, and osteoclastogenesis in mice and human. Mediators Inflamm.2014; 2014: 351856.
40 Ma C, Ma Z, Liao X L, Liu J, Fu Q, Ma S .Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4+CD25+Foxp3+ regulatory T cells in ovalbumin-sensitized mice. J Ethnopharmacol.2013; 148(3): 755-762.
41 Zhao M, Liang GP, Tang MN, Luo SY, Zhang J, Cheng WJ, Chan TM, Lu QJ.Total glucosides of paeony induces regulatory CD4+CD25+ T cells by increasing Foxp3 demethylation in lupus CD4+ T cells. Clin Immunol.2012; 143(2): 180-187.
42 Zwickey H, Brush J, Iacullo CM, Connelly E, Gregory WL, Soumyanath A, Buresh R.The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study. Phytother Res.2007; 21(11): 1109-1112.
43 Li HY, Feng SZ, Han MZ. Preliminary study on TCM syndrome differentiation of graft versus host disease after transplantation of hematopoietic stem cell. Zhong Yi Za Zhi.2005; 16(8): 617-618. Chinese with abstract in English.
44 Li HY, Feng SZ, Han MZ, Qian LS. Fever of unknown origin after transplantation of hemopoietic stem-cells in 15 cases of leukemia. Zhong Yi Za Zhi.1999; 40(8): 482-483. Chinese with abstract in English.
45 Li HY, Feng SZ, Qian LS, Han MZ. Investigation on picture of the tongue before and after transplantation of hemopoietic stem cells in 44 cases of malignant hematopathy. Zhong Yi Za Zhi.2000; 41(7): 422. Chinese with abstract in English.
46 Li D, Liu K, Hu YZ.Treatment of hematopathy by Tiaohe Ganpi recipe in assisting the hematopoietic stem cell transplantation. Zhongguo Zhong Xi Yi Jie He Za Zhi.2011; 31(5): 626-630. Chinese with abstract in English.
47 Li J, Wang MS, Yang SL, Han EY.Analysis of type and onset factors of 1 040 cases of acute leukemia. Lin Chuang Xue Ye Xue Za Zhi.2011; 24(3): 178-179. Chinese with abstract in English.
48 Wang MS, Yang SL, Duan LF, Sun ZY, Zhou ZH, Yan JY, Li ZL, Zhao XM.Observational study of combined Chinese medicine for the clinical treatment of autologous HSCT for refractory AML. Zhongguo Zhong Xi Yi Jie He Za Zhi.2011; 31(6): 847-850. Chinese with abstract in English.
49 Kim MG, Han N, Lee EK, Kim T.Pegfilgrastim vs filgrastim in PBSC mobilization for autologous hematopoietic SCT: a systematic review and meta-analysis. Bone Marrow Transplant.2015; 50(4): 523-530.
50 Shi L, Cheng Z, Chen SM, Qin XL, Wang H.Autologous peripheral blood stem cell transplantation combined with traditional Chinese medicine therapy on acute leukemia in children. Shi Yong Er Ke Lin Chuang Za Zhi.2010; 25(3): 209-210. Chinese with abstract in English.
51 Yu RX, Zhou YH, Zhu NX.Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi.2001; 21(2): 90-93. Chinese with abstract in English.
52 Shen JP, Ye BD, Zhou YH.Treatment of refractory severe autoimmune disease by combined therapy with Chinese drug and autohemopoietic stem cell transplantation. Zhongguo Zhong Xi Yi Jie He Za Zhi.2008; 28(3): 212-215. Chinese with abstract in English.
53 Yang H, Zhuang HF, Hu ZP, Ye BD, Yu QH, Yu RX, Zhou YH, Chen JP.Clinical study on herpes zoster infection in patients after hematopoitic stem cell transplantation. Zhonghua Yi Zhi Za Zhi.2009; 3(4): 294-297. Chinese with abstract in English.
54 Leung TF, Chik KW, Li CK, Lai H, Shing MM, Chan PK, Lee V, Yuen PM.Incidence, risk factors and outcome of varicella-zoster virus infection in children after haematopoietic stem cell transplantation. Bone Marrow Transplant.2000; 25(2): 167-172.
55 Berman JN, Wang M, Berry W, Neuberg DS, Guinan EC.Herpes zoster infection in the post-hematopoietic stem cell transplant pediatric population may be preceded by transaminitis: an institutional experience. Bone Marrow Transplant.2006; 37(1): 73-80.
56 Steer CB, Szer J, Sasadeusz J, Matthews JP, Beresford JA, Grigg A.Varicella-zoster infection after allogeneic bone marrow transplantation: incidence, risk factors and prevention with low-dose aciclovir and ganciclovir. Bone Marrow Transplant.2000; 25(6): 657-664.
57 Ye BD, Zhang X, Shao KD, Chen D, Zhang Y, Wu DJ, Yu QH, Shen JP, Shen YP, Zhou YH.Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients. Chin J Integr Med. 2014; 20(12): 903-909.
58 Zhang Y, Ye BD, Qian LL, Gao YT, Wen XW, Shen JP, Zhou YH.Treatment of myelodysplastic syndrome by hematopoietic stem cell transplantation combined with Chinese medical syndrome typing: a clinical study. Zhongguo Zhong Xi Yi Jie He Za Zhi.2015; 35(1): 53-56. Chinese with abstract in English.
59 Li HY, Qian LS, Feng SZ.Clinical observation on treatment of complications with Chinese medicine according to syndrome differentiation of post-bone marrow transplantation in 22 patients with leukemia. Zhongguo Zhong Xi Yi Jie He Za Zhi.1997; 17(10): 581-583. Chinese with abstract in English.
60 Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, Linch DC.The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood.2001; 98(6): 1752-1759.
61 Paschka P, Marcucci G, Ruppert AS, Mrózek K, Chen H, Kittles RA, Vukosavljevic T, Perrotti D, Vardiman JW, Carroll AJ, Kolitz JE, Larson RA, Bloomfield CD, Cancer and Leukemia Group B. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study.J Clin Oncol. 2006; 24(24): 3904-3911.
62 Rubio MT, Labopin M, Blaise D, Socié G, Contreras RR, Chevallier P, Sanz MA, Vigouroux S, Huynh A, Shimoni A, Bulabois CE, Caminos N, López-Corral L, Nagler A, Mohty M.The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Haematologica.2015; 100(5): 683-689.
63 Lahans T.Integrating conventional and Chinese medicine in cancer care: a clinical notebook. Philadelphia: Elsevier. 2007: 293.
64 Kawashima N, Ito Y, Sekiya Y, Narita A, Okuno Y, Muramatsu H, Irie M, Hama A, Takahashi Y, Kojima S.Choreito formula for BK virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant.2015; 21(2): 319-325.
[1] Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[2] Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[3] Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[4] Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[5] Shu-yi Chen, Qun-wei Chen, Liu-mei Shou, Hong Pan, Shan-ming Ruan, Zhe-hao Liang, Qi-jin Shu. Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report. Journal of Integrative Medicine, 2021, 19(6): 555-560.
[6] Yi Yuan, Rui-Ting Wang, Jun Xia, Hui-Juan Cao. Interventions for preventing influenza: an overview of Cochrane systematic reviews and a Bayesian network meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 503-514.
[7] Xin Yin, Shu-bin Cai, Lan-ting Tao, Lu-ming Chen, Zhong-de Zhang, Su-hong Xiao, Arthur Yin Fan, Xu Zou. Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care. Journal of Integrative Medicine, 2021, 19(5): 460-466.
[8] Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[9] Liang Dai, Ka Kei Chan, Jian-chun Mao, Yu Tian, Jun-hua Gu, Jun Zhou, Linda L.D. Zhong. Modified Zhibai Dihuang pill, a traditional Chinese medicine formula, on steroid withdrawal in systemic lupus erythematosus: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(6): 478-491.
[10] Qing-lan Wang, Yan-yan Tao, Hong-dong Xie, Cheng-hai Liu, Ping Liu. Fuzheng Huayu recipe, a traditional Chinese compound herbal medicine, attenuates renal interstitial fibrosis via targeting the miR-21/PTEN/AKT axis. Journal of Integrative Medicine, 2020, 18(6): 505-513.
[11] Ming-sheng Lyu, De-ying Li, Shao-zhong Zhou, Cheng-jun Ban, Jun Yan. Adult-onset Still's disease successfully treated with Chinese herbal medicine: A case report with 15-month follow-up. Journal of Integrative Medicine, 2020, 18(6): 530-534.
[12] Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[13] Xian-jun Xiao, Lei-xiao Zhang, Yun-zhou Shi, Jun-peng Yao, Wei Cao, Ying Liu, Zi-hao Zou, Si-yuan Zhou, Ming-ling Chen, Chun-xiao Li, Qian-hua Zheng, Ying Li. Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 303-312.
[14] Dong-dong Yu, Liang-zhen You, Wan-qiu Huang, Hui Cao, Fan-jing Wang, Xiu-qin Tang, Zhao-hui Fang, Guo-ming Shen, Yu-xiang Guan. Effects of traditional Chinese exercises on blood glucose and hemoglobin A1c levels in patients with prediabetes: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 292-302.
[15] Bin Lan, Jin-wen Ge, Shao-wu Cheng, Xi-long Zheng, Jun Liao, Chao He, Zheng-qing Rao, Guo-zuo Wang. Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. Journal of Integrative Medicine, 2020, 18(4): 344-350.
Full text



[1] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2] Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[3] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[4] Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[5] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[6] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[7] Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[8] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[9] Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017
[10] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022